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Author Topic: changeing kaletra to truvada and sustiva pls help urgent  (Read 2101 times)

0 Members and 1 Guest are viewing this topic.

Offline sanitex

  • Member
  • Posts: 385
changeing kaletra to truvada and sustiva pls help urgent
« on: September 04, 2009, 01:09:50 AM »




hello guy
            my wife is on (kaletra,tonofovir,lamuvidine,)once a night and i told our ID DOC if he could change her combo to another due to too much pills of kaletra.,i suggest(TRUVADA,and SUSTIVA)Because this is the only two or three pills combo available in thailand now.

but our doc was afraid of resistance if she has problem of the combo she cannot go back to kaletra again,so pls help us on what will be the best option. my question is can she use truvada and sustiva at the same hence truvada is like tenofovir and lamuvidine? and this morning she to see our ID doc and she was order to take blood test about her iron or RBC and the result came out with low iron or RBC so what can she do to recover back
thanks sanitex
« Last Edit: September 04, 2009, 01:48:13 AM by sanitex »
27/12/07 cd4 20 vl 1million
10/4 /08 cd4 86 vl 63
1/7/08  cd4 186 vl undetectable
16/10/08 cd4 196 vl undet
23/1/09 cd4 248 vl un
10/9/11 cd4 418 vl <40 %22
13/12/11 cd4 410 vl undet 23%
24/2/12 cd4 545 vl undet 26%
on 22/2/12 change truvada to Recovir-EM
due to no stock on Truvada.
10/9/11 cd4 418 vl <40 %22
7/7/12 cd4 359 vl <40 22%
23/8/12 cd4 400 vl <40 23%,
testosterone test 7.5 ng/ml and
thyroid (TSH)1.32 ulu/ml creatinine.eGFR blck 1.5 all fasting test morning.
13/12/2012 cd4 523 24% vl <40
18/3/2013 cd4  513  23% vl <40
regimen ATRIPLA
03/8/2013 cd4 429 22% vl <40
13/11/2013 cd4 455 23% vl <40
Anti-HBs test (quantitative ) Anti-HBs positive
Titer 16.95 mlu/ml <10.00
22/3/14 cd4 396 vl <40 % 24

Offline BlueMoon

  • Member
  • Posts: 665
  • Calling from the Fun House
Re: changeing kaletra to truvada and sustiva pls help urgent
« Reply #1 on: September 04, 2009, 07:16:13 AM »
Truvada and Sustiva is a common regimen. 

I'm not clear on what's the problem.  It seems unwise to switch from a successful regimen just to take one or two fewer pills a day.
...................VL.....CD4.....%
-----------------------------------------
08/10-- ......<40.....290.....42
05/10-- ......<48.....290.....46
02/10-- ......<48.....481.....44
10/09-- ......<48.....277.....46
07/09-- ......<48.....300.....38
05/09-- ........51.....449.....39
03/09-- Added Isentress
02/09-- ........65.....299.....34
11/08-- ........62.....242.....40
08/08-- ........66.....212.....29
05/08-- ......202.....217.....27
03/08-- ....5210.....187.....21
02/08-- Began Truvada/Reyataz/Norvir
12/07-- 273,000.....157.....22
11/07-- 229,000.....209.....22
10/07-- Diagnosis

It's a complex world.

Offline bocker3

  • Member
  • Posts: 3,358
  • You gotta enjoy life......
Re: changeing kaletra to truvada and sustiva pls help urgent
« Reply #2 on: September 04, 2009, 07:59:23 AM »
I don't think that changing from one regimen to another automatically means that the first one is now "off limits".  Resistance to a drug is main reason one can't go back (well, unbearable side effects too), and you aren't indicating that the current regimen isn't working.

Mike
Atripla - Started 12/05
Reyataz/Norvir - Added 6/06
Labs - Pre-Meds
Sep05 T=350/25% VL98,559
Nov05 288/18%  47,564
Current Labs
May2013 691/31% <20

Offline sanitex

  • Member
  • Posts: 385
Re: changeing kaletra to truvada and sustiva pls help urgent
« Reply #3 on: September 05, 2009, 02:15:17 AM »
Truvada and Sustiva is a common regimen. 

I'm not clear on what's the problem.  It seems unwise to switch from a successful regimen just to take one or two fewer pills a day.

hello,reason why we want  to change the regimen is not that it's not working but due to the price of Kaletra here in thailand the cost is 8000baht and the pills was not like the American type it's about 8tabs not like 4tabs.and in bangkok we can only get that type at the welfare office and by then she need to show her social security tax which look like she've to disclose her status to every hospital and nurses and moreover she's thai.
27/12/07 cd4 20 vl 1million
10/4 /08 cd4 86 vl 63
1/7/08  cd4 186 vl undetectable
16/10/08 cd4 196 vl undet
23/1/09 cd4 248 vl un
10/9/11 cd4 418 vl <40 %22
13/12/11 cd4 410 vl undet 23%
24/2/12 cd4 545 vl undet 26%
on 22/2/12 change truvada to Recovir-EM
due to no stock on Truvada.
10/9/11 cd4 418 vl <40 %22
7/7/12 cd4 359 vl <40 22%
23/8/12 cd4 400 vl <40 23%,
testosterone test 7.5 ng/ml and
thyroid (TSH)1.32 ulu/ml creatinine.eGFR blck 1.5 all fasting test morning.
13/12/2012 cd4 523 24% vl <40
18/3/2013 cd4  513  23% vl <40
regimen ATRIPLA
03/8/2013 cd4 429 22% vl <40
13/11/2013 cd4 455 23% vl <40
Anti-HBs test (quantitative ) Anti-HBs positive
Titer 16.95 mlu/ml <10.00
22/3/14 cd4 396 vl <40 % 24

Offline sanitex

  • Member
  • Posts: 385
Re: changeing kaletra to truvada and sustiva pls help urgent
« Reply #4 on: September 06, 2009, 10:38:48 PM »
hello

               she has problem of( thalassemia)RBCs
27/12/07 cd4 20 vl 1million
10/4 /08 cd4 86 vl 63
1/7/08  cd4 186 vl undetectable
16/10/08 cd4 196 vl undet
23/1/09 cd4 248 vl un
10/9/11 cd4 418 vl <40 %22
13/12/11 cd4 410 vl undet 23%
24/2/12 cd4 545 vl undet 26%
on 22/2/12 change truvada to Recovir-EM
due to no stock on Truvada.
10/9/11 cd4 418 vl <40 %22
7/7/12 cd4 359 vl <40 22%
23/8/12 cd4 400 vl <40 23%,
testosterone test 7.5 ng/ml and
thyroid (TSH)1.32 ulu/ml creatinine.eGFR blck 1.5 all fasting test morning.
13/12/2012 cd4 523 24% vl <40
18/3/2013 cd4  513  23% vl <40
regimen ATRIPLA
03/8/2013 cd4 429 22% vl <40
13/11/2013 cd4 455 23% vl <40
Anti-HBs test (quantitative ) Anti-HBs positive
Titer 16.95 mlu/ml <10.00
22/3/14 cd4 396 vl <40 % 24

Offline Tempeboy

  • Member
  • Posts: 356
  • Like St Francis of Assisi I am wedded to Poverty
Re: changeing kaletra to truvada and sustiva pls help urgent
« Reply #5 on: September 07, 2009, 03:04:28 AM »
Hey Sanitex,

Pill burden is a common reason for people choosing to change combinations, especially if they are paying per tablet - a 'streamlined' combination can be easier to take and less expensive. 

Abbott have received alot of criticism internationally for their reluctance to discount Kaletra to governments struggling with the cost of making medication available to many.

If your wife is taking:

Tenofovir + lamivudine + kaletra, then swapping to Truvada and Sustiva will give:

Truvada = (Tenofovir + emtricitabine) + Efavirenz

Emtricitabine and lamivudine have the same resistance profile, so this is an easy and safe switch.

Efavirenz will be effective unless there is resistance to the NNRTI group - this can be checked with a blood test - you will need to ask about cost.

In some countries Truvada and Efavirenz are available in 1 pill taken once a day.

There are many potential causes of thalassemia in people with HIV - this would need further investigation by a doctor.

take care.



« Last Edit: September 07, 2009, 03:07:08 AM by Tempeboy »
Roughly roundabout somewhere in the eighteenth or nineteenth century, Sodomite begat Homosexual out of moral, medical and legal models, bequeathing him Identity, who inbred with Nuclear Family and Industrialism to spawn Homophobia.

Dean Kiley

Offline sanitex

  • Member
  • Posts: 385
Re: changeing kaletra to truvada and sustiva pls help urgent
« Reply #6 on: September 07, 2009, 04:41:58 AM »

If your wife is taking:

Tenofovir + lamivudine + kaletra, then swapping to Truvada and Sustiva will give:

Truvada = (Tenofovir + emtricitabine) + Efavirenz

Emtricitabine and lamivudine have the same resistance profile, so this is an easy and safe switch.

Efavirenz will be effective unless there is resistance to the NNRTI group - this can be checked with a blood test - you will need to ask about cost.

In some countries Truvada and Efavirenz are available in 1 pill taken once a day.

There are many potential causes of thalassemia in people with HIV - this would need further investigation by a doctor.

take car

hello Tempeboy
                         thanks for your advice and urgent reply i appreciate it very much i thought this gave more impression on what to do.so my question is ,is't posible to switch to this Truvada and sustiva without wait for the kaletra to purify first then switch on?or can she just start it immediatily she stop kaletra?
27/12/07 cd4 20 vl 1million
10/4 /08 cd4 86 vl 63
1/7/08  cd4 186 vl undetectable
16/10/08 cd4 196 vl undet
23/1/09 cd4 248 vl un
10/9/11 cd4 418 vl <40 %22
13/12/11 cd4 410 vl undet 23%
24/2/12 cd4 545 vl undet 26%
on 22/2/12 change truvada to Recovir-EM
due to no stock on Truvada.
10/9/11 cd4 418 vl <40 %22
7/7/12 cd4 359 vl <40 22%
23/8/12 cd4 400 vl <40 23%,
testosterone test 7.5 ng/ml and
thyroid (TSH)1.32 ulu/ml creatinine.eGFR blck 1.5 all fasting test morning.
13/12/2012 cd4 523 24% vl <40
18/3/2013 cd4  513  23% vl <40
regimen ATRIPLA
03/8/2013 cd4 429 22% vl <40
13/11/2013 cd4 455 23% vl <40
Anti-HBs test (quantitative ) Anti-HBs positive
Titer 16.95 mlu/ml <10.00
22/3/14 cd4 396 vl <40 % 24

Offline sanitex

  • Member
  • Posts: 385
Re: changeing kaletra to truvada and sustiva pls help urgent
« Reply #7 on: September 07, 2009, 04:45:35 AM »

hello Tempeboy
                         thanks for your advice and urgent reply i appreciate it very much i thought this gave more impression on what to do.so my question is ,is't posible to switch to this Truvada and sustiva without wait for the kaletra to purify first then switch on?or can she just start it immediatily she stop kaletra? coming to the resistance issue she has never use any of the NNRTIs before .her vl is 40 undetectable and cd4 is 255 as of three month ago,



[/quote]
« Last Edit: September 07, 2009, 05:08:39 AM by sanitex »
27/12/07 cd4 20 vl 1million
10/4 /08 cd4 86 vl 63
1/7/08  cd4 186 vl undetectable
16/10/08 cd4 196 vl undet
23/1/09 cd4 248 vl un
10/9/11 cd4 418 vl <40 %22
13/12/11 cd4 410 vl undet 23%
24/2/12 cd4 545 vl undet 26%
on 22/2/12 change truvada to Recovir-EM
due to no stock on Truvada.
10/9/11 cd4 418 vl <40 %22
7/7/12 cd4 359 vl <40 22%
23/8/12 cd4 400 vl <40 23%,
testosterone test 7.5 ng/ml and
thyroid (TSH)1.32 ulu/ml creatinine.eGFR blck 1.5 all fasting test morning.
13/12/2012 cd4 523 24% vl <40
18/3/2013 cd4  513  23% vl <40
regimen ATRIPLA
03/8/2013 cd4 429 22% vl <40
13/11/2013 cd4 455 23% vl <40
Anti-HBs test (quantitative ) Anti-HBs positive
Titer 16.95 mlu/ml <10.00
22/3/14 cd4 396 vl <40 % 24

Offline markaj

  • Member
  • Posts: 80
Re: changeing kaletra to truvada and sustiva pls help urgent
« Reply #8 on: September 07, 2009, 07:30:06 AM »
I switched immediately from Kaletra and Truvada to Susitva and Truvada before I was undetectable with no problems, given that your wife is undetectable I can't see an issue.
Infected Jan 08 / diagnosed Feb 08
Feb 08 - CD4 230 (9%) VL 3.5 million
Mar 08 - CD4 440 (6%) VL 660.000
Apr 08 - CD4 420 (11%) VL 3 million
Jun 08 - CD4 200 (7%) VL 3 million
Started Kaletra/Truvada Jul 08
Jul 08  - CD4 250 (14%) VL 23.893
Aug 08 - CD4 410 (15%)  VL 4.313
Switched to Sustiva/Truvada Aug 08
Switched to Reyataz/Norvir/Truvada Sep 08
Diagnosed with Hep C, HIV meds stopped for a bit
Nov 08 - CD4 414 (12%) VL 500.000+
Started Isentress/Truvada Nov 2008
Dec 08 - CD4 381 (17%) VL 1.116
Jan 09 - CD4 534 (20%) VL <50
Started Interferon/Ribavirin Jan 09
Feb 09 - CD4 407 (24%) VL <50
Mar 09 - CD4 360 (28%) VL <50
Apr 09 - CD4 279 (30%) VL <50
Jun 09 - CD4 298 (36%) VL <50
Aug 09 - CD4 303 (35%) VL <50

Offline sanitex

  • Member
  • Posts: 385
Re: changeing kaletra to truvada and sustiva pls help urgent
« Reply #9 on: September 14, 2009, 12:20:18 AM »
hello guys
                     


                    pls do not misunderstood me by posting this topic here ,while because i don't want to creating another newtopic again here hence you guys have read the topic before i'd like to know something. my question are ,as we are on diffrent combo is't possible to have unprotect sex,?or can we put ourselves in resistance issue? or inasmuch as we are undetectable we can have it?pls help


27/12/07 cd4 20 vl 1million
10/4 /08 cd4 86 vl 63
1/7/08  cd4 186 vl undetectable
16/10/08 cd4 196 vl undet
23/1/09 cd4 248 vl un
10/9/11 cd4 418 vl <40 %22
13/12/11 cd4 410 vl undet 23%
24/2/12 cd4 545 vl undet 26%
on 22/2/12 change truvada to Recovir-EM
due to no stock on Truvada.
10/9/11 cd4 418 vl <40 %22
7/7/12 cd4 359 vl <40 22%
23/8/12 cd4 400 vl <40 23%,
testosterone test 7.5 ng/ml and
thyroid (TSH)1.32 ulu/ml creatinine.eGFR blck 1.5 all fasting test morning.
13/12/2012 cd4 523 24% vl <40
18/3/2013 cd4  513  23% vl <40
regimen ATRIPLA
03/8/2013 cd4 429 22% vl <40
13/11/2013 cd4 455 23% vl <40
Anti-HBs test (quantitative ) Anti-HBs positive
Titer 16.95 mlu/ml <10.00
22/3/14 cd4 396 vl <40 % 24

Offline sanitex

  • Member
  • Posts: 385
Re: changeing kaletra to truvada and sustiva pls help urgent
« Reply #10 on: September 16, 2009, 05:38:19 AM »



             hello,does it mean that my question look helpless?
hello guys
                     


                    pls do not misunderstood me by posting this topic here ,while because i don't want to creating another newtopic again here hence you guys have read the topic before i'd like to know something. my question are ,as we are on diffrent combo is't possible to have unprotect sex,?or can we put ourselves in resistance issue? or inasmuch as we are undetectable we can have it?pls help



27/12/07 cd4 20 vl 1million
10/4 /08 cd4 86 vl 63
1/7/08  cd4 186 vl undetectable
16/10/08 cd4 196 vl undet
23/1/09 cd4 248 vl un
10/9/11 cd4 418 vl <40 %22
13/12/11 cd4 410 vl undet 23%
24/2/12 cd4 545 vl undet 26%
on 22/2/12 change truvada to Recovir-EM
due to no stock on Truvada.
10/9/11 cd4 418 vl <40 %22
7/7/12 cd4 359 vl <40 22%
23/8/12 cd4 400 vl <40 23%,
testosterone test 7.5 ng/ml and
thyroid (TSH)1.32 ulu/ml creatinine.eGFR blck 1.5 all fasting test morning.
13/12/2012 cd4 523 24% vl <40
18/3/2013 cd4  513  23% vl <40
regimen ATRIPLA
03/8/2013 cd4 429 22% vl <40
13/11/2013 cd4 455 23% vl <40
Anti-HBs test (quantitative ) Anti-HBs positive
Titer 16.95 mlu/ml <10.00
22/3/14 cd4 396 vl <40 % 24

 


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