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Author Topic: Anyone seen this?  (Read 1264 times)

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Offline BM

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Anyone seen this?
« on: August 09, 2009, 05:17:52 PM »
Apologies if it has been posted before.


http://www.natap.org/2009/PK/PK_10.htm

Offline Inchlingblue

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Re: Anyone seen this?
« Reply #1 on: August 09, 2009, 07:57:07 PM »
Good article, thanks for posting, I don't believe it was posted or discussed before.

There was a previous article that attributed Isentress's potency to it's "off-rate," or the amount of time the drug remains bound or attached to the integrase enzyme.

It seems based on all these findings, that the normal way to measure pharmacokinetics don't apply with integrase inhibitors.

LINK:

Study Data Explain Isentress' Excellent Resistance Profile

http://www.thebody.com/content/confs/icaac2008/art49168.html

 


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