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Author Topic: Treatment Ineffective in 15%?  (Read 1546 times)

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Offline northernguy

  • Member
  • Posts: 1,347
Treatment Ineffective in 15%?
« on: June 24, 2009, 09:31:52 PM »
In one of the articles about the HAART - Chemo combo possibilities, I found the stat that HAART is ineffective in 15% of the HIV+ population!  That shocked me, has anyone else seen that figure?
Apr 28/06 cd4 600 vl 10,600 cd% 25
Nov 8/09 cd4 510 vl 49,5000 cd% 16
Jan 16/10 cd4 660 vl 54,309 cd% 16
Feb 17/10 Started Atripla
Mar 7/10 cd4 710 vl 1,076 cd% 21
Apr 18/10 cd4 920 vl 268 cd% 28
Jun 19/10 cd4 450 vl 60 cd% 25
Aug 15/10 cd4 680 vl 205 cd% 27
Apr 3/11 cd4 780 vl <40 cd% 30
Jul 17/11 cd4 960 vl <40 cd%33
April 15/12 cd4 1,010 vl <40 cd% 39
April 20/12 Switched to Viramune + Truvada
Aug 2/12 cd4 1040, vl <40, cd% 38
Oct 19 cd4 1,110 vl <40 cd% 41

Offline positivmat

  • Member
  • Posts: 222
Re: Treatment Ineffective in 15%?
« Reply #1 on: June 24, 2009, 10:09:17 PM »
I thought that was way high too. Would like to hear more about that

Offline Miss Philicia

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  • Posts: 24,519
  • celebrity poster, faker & poser
Re: Treatment Ineffective in 15%?
« Reply #2 on: June 24, 2009, 10:21:58 PM »
I wouldn't be surprised if that figure is that high exactly because of those long-term survivors that developed resistance issues from pre-HAART regimens, so even now days they often develop resistance issues.  Combined with post-HAART patients with adherence issues (untreated mental health issues and substance abuse often drive those numbers) and it's easy to see this.

Of course, maybe some of you just want something new to worry incessantly about.
"Iíve slept with enough men to know that Iím not gay"

Offline positivmat

  • Member
  • Posts: 222
Re: Treatment Ineffective in 15%?
« Reply #3 on: June 24, 2009, 10:39:48 PM »
Well worrying is a great hobby if you can perfect it. I wasn't too worried the hour long session it took me to get this bug. No my atripla is working fine. The LTS explains it. I assumed they meant first line treatment.
Matt

Offline Assurbanipal

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  • Posts: 2,173
  • Taking a forums break, still see PM's
Re: Treatment Ineffective in 15%?
« Reply #4 on: June 25, 2009, 09:33:22 AM »
Believe that is a per regimen number.  It's consistent with the following observation in the US treatment guidelines that broadly summarizes clinical trial results:

"Successful outcomes are not always observed. Viral suppression rates in clinical practice may be lower than the 80%Ė90% seen in clinical trials, although the use of current compact, potent, and well-tolerated regimens has probably decreased this difference in outcomes between clinical trials and clinical practice"
http://aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf  p.18

But just generally, depending on the study, 10% to 20% of the late diagnosed (have AIDS at diagnosis) die within a year of diagnosis.  About 30% to 40% are late diagnosed.  That would account for about half of the 15% number.

Some of the remainder are accounted for by the statement in the US treatment guidelines per regimen.

And finally, treatment experienced with multidrug resistant virus.

Medicine doesn't have guarantees; there is room for gratitude and wonder that we remain alive...
5/06 VL 1M+, CD4 22, 5% , pneumonia, thrush -- O2 support 2 months, 6/06 +Kaletra/Truvada
9/06 VL 3959 CD4 297 13.5% 12/06 VL <400 CD4 350 15.2% +Pravachol
2007 VL<400, 70, 50 CD4 408-729 16.0% -19.7%
2008 VL UD CD4 468 - 538 16.7% - 24.6% Osteoporosis 11/08 doubled Pravachol, +Calcium/D
02/09 VL 100 CD4 616 23.7% 03/09 VL 130 5/09 VL 100 CD4 540 28.4% +Actonel (osteoporosis) 7/09 VL 130
8/09  new regimen Isentress/Epzicom 9/09 VL UD CD4 621 32.7% 11/09 VL UD CD4 607 26.4% swap Isentress for Prezista/Norvir 12/09 (liver and muscle issues) VL 50
2010 VL UD CD4 573-680 26.1% - 30.9% 12/10 VL 20
2011 VL UD-20 CD4 568-673 24.7%-30.6%
2012 VL UD swap Prezista/Norvir for Reyataz drop statin CD4 768-828 26.7%-30.7%

Offline hotpuppy

  • Member
  • Posts: 555
Re: Treatment Ineffective in 15%?
« Reply #5 on: June 25, 2009, 11:34:21 AM »
I think you need to look at the population.  In general, guys who do drugs, party, drink like fish, and live hard tend to also skip doses, and thus fail treatment.  Is that the treatment's fault?  I don't think so.

We all have choices to make that influence how long we live.  Do you take your meds? Show respect to large moving vehicles when crossing the street? both decisions impact the extent of your life.  If you don't put your meds first you aren't putting your life first.  It's that simple.  It's that serious.
Don't obsess over the wrong things.  Life isn't about your numbers, it isn't about this forum, it isn't about someone's opinion.  It's about getting out there and enjoying it.   I am a person with HIV - not the other way around.

Offline Miss Philicia

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  • Posts: 24,519
  • celebrity poster, faker & poser
Re: Treatment Ineffective in 15%?
« Reply #6 on: June 25, 2009, 12:57:39 PM »
I see plenty of straight women at my clinic that are drug users.  This isn't just a gay man's disease.
"Iíve slept with enough men to know that Iím not gay"

Offline dixieman

  • Member
  • Posts: 889
Re: Treatment Ineffective in 15%?
« Reply #7 on: June 25, 2009, 04:15:03 PM »
I see plenty of straight women at UAB in Birming, AL where their boyfriends and husbands have brought home this virus likewise.

 


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