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Author Topic: This could lead to an Anti-HIV drug resistant to mutations!  (Read 2936 times)

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Offline blondbeauty

  • Member
  • Posts: 1,784
The only member in these forums approved by WINBA: World International Nail and Beauty Association.
Epstein Barr +; CMV +; Toxoplasmosis +; HIV-1 +.
Counts when starting treatment:
V.L.:80.200 copies. CD4: 25%=503
Started Sustiva-Truvada 14/August/2006
Last V.L.count (Oct 2013): Undetectable
Last CD4 count (OCT 2013): 52%= 933

Offline J220

  • Member
  • Posts: 587
Re: This could lead to an Anti-HIV drug resistant to mutations!
« Reply #1 on: August 07, 2006, 12:00:38 AM »
It just gives me so much hope when I read articles like this.

I wonder what kind of drugs would work to bind to PIP2, and what level of toxicity they would have?
"Hope is my philosophy
Just needs days in which to be
Love of Life means hope for me
Born on a New Day" - John David

Offline J220

  • Member
  • Posts: 587
Re: This could lead to an Anti-HIV drug resistant to mutations!
« Reply #2 on: August 09, 2006, 09:28:29 AM »
I sent the staff at HHMI an email asking for any other information they might have on this. I also read on Dr. Summer's bio that he identified a new class of compounds that inhibit a key protein involved in the transformation of HIV into its mature form. Let's hope all this leads to great things! J.
"Hope is my philosophy
Just needs days in which to be
Love of Life means hope for me
Born on a New Day" - John David

Offline J220

  • Member
  • Posts: 587
Re: This could lead to an Anti-HIV drug resistant to mutations!
« Reply #3 on: August 12, 2006, 03:54:59 PM »
Okay I've learned that the people behind this discovery are already working on a possible deal with a pharmaceutical company to develop this. They have preliminarly identified a substance that seems to inhibit PIP2, the chemical signpost that hiv uses to attach to cellular membranes.

If this works, we are looking at a drug that would effectively block hiv from infecting cells, and not be subject to resistance issues. Fingers crossed.

J.
"Hope is my philosophy
Just needs days in which to be
Love of Life means hope for me
Born on a New Day" - John David

Offline blondbeauty

  • Member
  • Posts: 1,784
Re: This could lead to an Anti-HIV drug resistant to mutations!
« Reply #4 on: August 12, 2006, 04:48:15 PM »
Thats great news. But we have to be realistic. If this substance works it is still 10 years far in time.
The only member in these forums approved by WINBA: World International Nail and Beauty Association.
Epstein Barr +; CMV +; Toxoplasmosis +; HIV-1 +.
Counts when starting treatment:
V.L.:80.200 copies. CD4: 25%=503
Started Sustiva-Truvada 14/August/2006
Last V.L.count (Oct 2013): Undetectable
Last CD4 count (OCT 2013): 52%= 933

 


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