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Author Topic: More comments please - Intelence Truvada - is this enough?  (Read 4976 times)

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Offline mecch

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More comments please - Intelence Truvada - is this enough?
« on: March 25, 2009, 09:29:52 PM »
I was on Reyatz and Norvir and had an allergic reaction.  Now hy HIV ID Specialist switched me to Intelence and Truvada.  The asumption is that with Sustiva Truvada I was not going to undetectable. Now i see eperts wondering why Intelence and Truvada but no PI.  This makes e anxious - who do i qustions the prescription if ihe is supposed to be th great Swiss expert?
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline aztecan

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Re: More comments please - Intelence Truvada - is this enough?
« Reply #1 on: March 25, 2009, 11:11:04 PM »
Hey Mecch,
You are on a perfectly acceptable regimen: Two nukes (Emtriva and Viread combined as Truvada) and a non-nuke (Intelence).

You are taking three drugs from two different classes, which is the goal of triple-drug therapy. There is no reason to add a fourth, such as a PI, unless you should need to in some sort of salvage regimen

I did read your lab history in your tag line. I was wondering why you switched from Sustiva? Was it a side effect issue or a viral breakthrough.

I am assuming your doctor wouldn't have put you on another non-nuke if you had resistance to it. Did your doctor do a resistance test?

As I said, what you are being prescribed is a perfectly acceptable regimen. If memory serves, Intelence is even used in some people who have developed resistance to other non-nukes.

I you have real concerns, I would have a heart-to-heart with the doctor to put your mind at rest.

HUGS,

Mark


HUGS,

Mark
« Last Edit: March 25, 2009, 11:20:10 PM by aztecan »
"May your life preach more loudly than your lips."
~ William Ellery Channing (Unitarian Minister)

Offline Miss Philicia

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Re: More comments please - Intelence Truvada - is this enough?
« Reply #2 on: March 25, 2009, 11:52:17 PM »
ditto what Mark said.  meech, when you see others on a 4th drug to the standard HAART (like me for example) it's because we need to be to suppress the virus, due to (at least in my case) taking 13 years to get to undetectable, due to my pre-HAART dual therapy having fucked me up.
"I’ve slept with enough men to know that I’m not gay"

Offline mecch

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Re: More comments please - Intelence Truvada - is this enough?
« Reply #3 on: March 26, 2009, 05:02:24 AM »
Thanks for the feedback! 

Miss Philicia, how encoraging it must have been to have the CD4 jump when you finally found the effective combo. 

I went off Sustiva due to sustiva craziness (chills, anxiety, anger) but then I was allergic to Reyataz. I went back on Sustiva.  The ID was concerned that i was not undetectable, and wanted to avoid my Susitiva side effects. So switched me Intelence. 

My original resistance tests before medicine were 100% non-resistant.  So yes, I'm not on salvage, just need to find the combo that leads to undetectable with the least side effects. 

He has put "1000s" on HAART (depressing thought if you consider it in one way) so he must be knowledgeable.  His theory why not undetectable - 1) resistance the tests missed, and which is untestable now because my viral low is much too low. OR 2) my viral level was so high before HAART that my reservoir is particularly loaded so the low detectable virus level is shedding out from that. 

(Also, the original diagnosis last summer was that it appears I am genetically unable to fight the virus - complete viral escape from my natural immune response. It sobering to think that id be a gonner without medicine but there are certainly other diseases with the same deal....That's life I guess.  Then the ID said in the fall that he saw some natural immune response in addition to the HAART knockout - maybe he just said that make me feel better...)

In a nut shell he seems to favor theory 2) thus the new non-nuke but he said even if 1) Intelence has advantages (effective despite common mutations). 

« Last Edit: March 26, 2009, 05:21:36 AM by mecch »
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline bocker3

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Re: More comments please - Intelence Truvada - is this enough?
« Reply #4 on: March 26, 2009, 08:02:18 AM »
Another possibility for your ongoing low-level viremia, may be how your blood samples are being handled.  The first year or so after I started meds, I could not get to Undetectable.  However, when we tried a branched-DNA test (vs. the more common quantitative PCR test) I got the undetectable result (<75).  I then started having my blood drawn at a different site and when the Quant PCR was ordered by mistake -- it came back <50.  I have consistently been undetectable since -- with the Quant PCR test, but having my blood drawn at this new site.

So -- if you have had your blood drawn at the same place all this time, try going somewhere else, if possible.  It can't hurt and just might give you some peace.

Mike
Atripla - Started 12/05
Reyataz/Norvir - Added 6/06
Labs - Pre-Meds
Sep05 T=350/25% VL98,559
Nov05 288/18%  47,564
Current Labs
May2013 691/31% <20

Offline Miss Philicia

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Re: More comments please - Intelence Truvada - is this enough?
« Reply #5 on: March 26, 2009, 01:20:59 PM »
Thanks for the feedback! 

Miss Philicia, how encoraging it must have been to have the CD4 jump when you finally found the effective combo. 

Yes and no.  Yes, in my head it was quite nice, but my cd4s were fine before my viral load was suppressed unlike most people in my situation.  Suppressing my viral load was the largest game changer, as at the time of suppression it had been elevated for almost 2 decades if I was infected when I think it was.  Imagine what that does to one's body? 

I hope your new combo works for you.  It's disheartening to cycle through that many combos in a compressed time period, as I've done it myself plenty of times.  I will be interested to here how Intelence is tolerated as it's one of the few meds I've not been on.
"I’ve slept with enough men to know that I’m not gay"

Offline mecch

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Re: More comments please - Intelence Truvada - is this enough?
« Reply #6 on: March 26, 2009, 03:37:30 PM »
However, when we tried a branched-DNA test (vs. the more common quantitative PCR test) I got the undetectable result (<75).  I then started having my blood drawn at a different site and when the Quant PCR was ordered by mistake -- it came back <50. 

Wow thanks I will look into that for the April tests. Best!
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline mecch

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Re: More comments please - Intelence Truvada - is this enough?
« Reply #7 on: May 15, 2009, 05:22:31 AM »
Update, with new labs

Yeah Intelence and Truvada seems to be the ticket! (for me)

Of course, just when you think you've scored, they change the goal post - so my 33 VL is now "detectable" because they test down to 20 now. Hehehehe.  The ID said it is total control and its just dead virus being detected.

“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline Inchlingblue

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Re: More comments please - Intelence Truvada - is this enough?
« Reply #8 on: May 15, 2009, 01:07:34 PM »

 The ID said it is total control and its just dead virus being detected.


According to reports at the latest CROI, "the residual viremia is due to release of the virus from stable reservoirs."  This is a good thing! It means that, albeit slowly, the reservoirs are being depleted.

There had been a concern that residual viremia might be continuous and ongoing replication which appears not to be the case. If it were, there would be significant implications with developing resistance and would make the prospects of total eradication even bleaker.

So every time your blood work results come back with an actual count, be it 20, 30, 40, even 50 think of it as what it is: virus that is coming out of the reservoirs and getting summarily killed.

LINK:

http://www.thebody.com/content/confs/croi2009/art50467.html
« Last Edit: May 15, 2009, 04:15:02 PM by Inchlingblue »

Offline mecch

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Re: More comments please - Intelence Truvada - is this enough?
« Reply #9 on: May 15, 2009, 03:32:17 PM »
Seeing as i had instant viral loads in the multiple millions, i guess my "reservoirs" are filled to bursting. 

Well, hopefully some time down the road "they'll" figure out a way to pull the plug.  I visualise all those sleeping suckers waking up, running into my blood stream, and bam, nuked to death, mass annihilation!  Then I piss it all away, and the bad dream is over.
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline alberche

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Re: More comments please - Intelence Truvada - is this enough?
« Reply #10 on: March 13, 2010, 03:13:04 PM »
Hiya,

I just switched from Truvada Reyatz+Norvir to Truvada Intellence this week... I have developed osteopenia, maybe due to combined effect of Truvada and Reyataz on calcium methabolism...

By now it is going ok, unless for some secondary effects of the first days: headache, sensation of being numb and tired... I hope this will go well anyway!

 ;D
love is blindness...  a wonderful song!

 


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