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Author Topic: Boosted reyataz / truvada regimen - when do people take theirs?  (Read 4369 times)

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Offline skecherkid

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  • Posts: 9
I started my first ARV using a once-a-day therapy of reyataz with truvada and norvir.  The instructions say to take it once a day with "food" - and says preferably a full nutritious meal.  For me, a meal can be anything from a bowl of cereal and milk to a three course dinner, with levels in between.  I defaulted to taking my pills with dinner because that is the largest meal I eat each day.  But now I find that it is hard to keep my pill-taking time at the same time each evening because dinner time can vary quite a bit.  So I've been thinking - maybe take it with breakfast because I do that more consistently at the same time each morning.  But sometimes I sleep late.  So maybe lunch? 

The easiest solution would be to take the pills with a very light snack like maybe a protein shake or bar,  at the same time each afternoon.  But I don't know if that is enough food to eat with the pills. 

Has anyone had success keeping their intake at the same time each day - how do you manage it?

Thanks!

Offline newt

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  • the one and original newt
Re: Boosted reyataz / truvada regimen - when do people take theirs?
« Reply #1 on: March 22, 2009, 07:41:06 PM »
for the Norvir boost, 4g of fat.

for the Reyataz, 9g << the amount of fat in the original studies

for the tenofovir in Truvada, anything cos an empty stomach often = farts that destroy cities. More is absorbed with a high fat meal but you don;t need all the more.

not much eh?

Personally, lunchtime, whenever that is with whatever that is. Seems to work.

matt (undetectable 4+ years..or is that 3? can't remember) the newt
"The object is to be a well patient, not a good patient"

Offline BlueMoon

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Re: Boosted reyataz / truvada regimen - when do people take theirs?
« Reply #2 on: March 22, 2009, 07:42:03 PM »
I originally took my pills with dinner, but switched to breakfast after a few weeks because it's more regular for me, and then you don't have to think about it for the rest of the day.

I was told "food" meant a meal of at least 300 calories.  Usually I have a good breakfast but if I'm short of time or food in the house then a couple of sausage Mcbiscuits will suffice, or even a large Hershey bar and a pastry from the On The Go if I'm really running late.  

If you want to stay on a dinner dosing schedule, you might want to keep a supply of microwave meals on hand.  Those Lean Cuisine and Healthy Choice dinners run about 250 to 350 calories apiece, which is enough to let you take your meds properly.  

If you want to dose with an afternoon snack then maybe pump up the snack a bit with a handful of nuts and some fruit (but not grapefruit).
...................VL.....CD4.....%
-----------------------------------------
08/10-- ......<40.....290.....42
05/10-- ......<48.....290.....46
02/10-- ......<48.....481.....44
10/09-- ......<48.....277.....46
07/09-- ......<48.....300.....38
05/09-- ........51.....449.....39
03/09-- Added Isentress
02/09-- ........65.....299.....34
11/08-- ........62.....242.....40
08/08-- ........66.....212.....29
05/08-- ......202.....217.....27
03/08-- ....5210.....187.....21
02/08-- Began Truvada/Reyataz/Norvir
12/07-- 273,000.....157.....22
11/07-- 229,000.....209.....22
10/07-- Diagnosis

It's a complex world.

Offline denb45

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Re: Boosted reyataz / truvada regimen - when do people take theirs?
« Reply #3 on: March 22, 2009, 08:00:48 PM »
Truvavda I take it in the AM w/ Coffee Breakfast time, but the Norvir is taken twice a day, so, 200mg in the AM and 200Mg at night bedtime 400mg total norivr, and I have all of the side effects to go with it too, but, at bedtime I take the norivr w/ some Hershey's Milk Chocolate about 2 to 4 grams, not to much tho  ;D
« Last Edit: March 22, 2009, 08:03:39 PM by denb45 »
"it's so nice to be insane, cause no-one ask you to explain" Helen Reddy cc 1974

Offline Jacques

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Re: Boosted reyataz / truvada regimen - when do people take theirs?
« Reply #4 on: March 23, 2009, 12:30:58 AM »
Breakfeast and diner can vary a lot in my case but lunch time is relatively stable. So I decided to take my pills at lunch time with a moderate fatty meal and it works very well.

Jacques
Jacques
Living positively since 1987
latest lab :july 2010
Undetectable Cd4 1080
43% on Reyataz/Norvir/Truvada

Offline skecherkid

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Re: Boosted reyataz / truvada regimen - when do people take theirs?
« Reply #5 on: March 23, 2009, 06:29:52 PM »
Thanks all!  It's a great feeling to be able to learn from everyone's experiences.

Offline ad2san

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Re: Boosted reyataz / truvada regimen - when do people take theirs?
« Reply #6 on: July 19, 2009, 07:12:19 AM »
Hi,

I would like to catch up on this post ...

I started the combo beginning of May. A T+1M labor was nice VL 300 and CD4 459. I was taking the meds at 11:00 AM with a banana or so.
I had the follwoing problems though: dizziness, sweat ... and last but not least gas ! Having an afternoon meeting was so difficult (...).

So I progressively shifted the time for the meds (+1 hour every week) to 4:00 PM..
Then following problems appeared : I had to stand up at least 2 times a night (so time more) to pee ... as a result I woke up exhausted (not good). The gas problem remains. On top of it I have serious difficulty to get asleep (and then I wake up to go to the toilet and so on).

I tried to find out on the web at what time to take the combo is the best one. As I am close to dinner time, I am now shifting to 9:00 PM hoping it will help the falling asleep, pee, fart problems.

In your opinion, is this a better option? Any experience of the same kind?

I had also a lot of difficulties to find out how to change medication time and taking care of resistance ... Am I being cautious because "not experienced" I guess  ? Shifting carefully is somehow complicated ... especially when travelling.

Thanks in advance for your input.
« Last Edit: July 19, 2009, 07:14:39 AM by ad2san »
Feb   2009 CD4 358 VL 2000 16%
May  2009 CD4 305 VL 3069  14% <---- Started TVD+ATZ/r
Jul  2009 CD4 512 VL <50   18%
Jul 2010 CD4 418 VL <50 24%                     
Switched to Kivexa (Epzicom) + Norvir + Reyataz (due to sleep problem)
Aug 2010 CD4 606 VL <50 25%
Jul 2011 CD4 494 UD 23%
Switched to Kivexa (Epzicom) + Viramune XR (due to kidney problems)
January 2012 CD4 564 UD 31%
October 2012 CD4 684 UD 29%
January 2013 CD4 594 UD 26%
Switched to Kivexa (Epzicom) + Isentress due to BIG increase GammaGT
Feb 2013 CD4 699 UD 28%
May 2013 CD4 385 UD 28%
July 2013 CD4 CD4 636 UD 25%
Oct 2013 CD4 588 UD 39%
Aug 2014 CD4 639 UD 25%

Offline newt

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Re: Boosted reyataz / truvada regimen - when do people take theirs?
« Reply #7 on: July 19, 2009, 07:56:18 AM »
I wouldn't worry about the time shifting this combo, the drugs stay in your body a very long time

A banana is not enough food for this combo.

Specifically you need some fat, at least a glass of (proper) milk, but a sandwich or other snack with some fat in, or light meal is better. More food will most likely help with the gas probelm, which is from one of the drugs in Truvada  (tenofovir).

There is no best time, it depends on you.

Me I take it lunchtime mostly, but if my schedule suits breakfast more 9say at weeked) I'll take it then. this is just a personal thing, lunchtime is most consistent slot for regularity. Hmmm...but when I'm on holiday i do it dinner time....

- matt
"The object is to be a well patient, not a good patient"

Offline denb45

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Re: Boosted reyataz / truvada regimen - when do people take theirs?
« Reply #8 on: July 19, 2009, 08:15:25 AM »
I wouldn't worry about the time shifting this combo, the drugs stay in your body a very long time

A banana is not enough food for this combo.

Specifically you need some fat, at least a glass of (proper) milk, but a sandwich or other snack with some fat in, or light meal is better. More food will most likely help with the gas probelm, which is from one of the drugs in Truvada  (tenofovir).

There is no best time, it depends on you.

Me I take it lunchtime mostly, but if my schedule suits breakfast more 9say at weeked) I'll take it then. this is just a personal thing, lunchtime is most consistent slot for regularity. Hmmm...but when I'm on holiday i do it dinner time....

- matt


I take all my Meds every 12 hrs..........this works for me, and is also a habit as well after, so many yrs. of Meds
"it's so nice to be insane, cause no-one ask you to explain" Helen Reddy cc 1974

Offline ad2san

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Re: Boosted reyataz / truvada regimen - when do people take theirs?
« Reply #9 on: July 19, 2009, 08:27:56 AM »
Hi there,

Concerning the shifting the time, do you think that I could for example shift tonite and take the meds starting from today at 09:00 PM instead of 05:00 PM ?

I kind of guess that it would not matter that much in the over direction since the concentration in the blood would be then superior ... but delaying ??

@newt, if I take the combo around 09:00 PM it would be always within 1 hour after diner, it would do the trick for Gas stuff.

Thanks
Feb   2009 CD4 358 VL 2000 16%
May  2009 CD4 305 VL 3069  14% <---- Started TVD+ATZ/r
Jul  2009 CD4 512 VL <50   18%
Jul 2010 CD4 418 VL <50 24%                     
Switched to Kivexa (Epzicom) + Norvir + Reyataz (due to sleep problem)
Aug 2010 CD4 606 VL <50 25%
Jul 2011 CD4 494 UD 23%
Switched to Kivexa (Epzicom) + Viramune XR (due to kidney problems)
January 2012 CD4 564 UD 31%
October 2012 CD4 684 UD 29%
January 2013 CD4 594 UD 26%
Switched to Kivexa (Epzicom) + Isentress due to BIG increase GammaGT
Feb 2013 CD4 699 UD 28%
May 2013 CD4 385 UD 28%
July 2013 CD4 CD4 636 UD 25%
Oct 2013 CD4 588 UD 39%
Aug 2014 CD4 639 UD 25%

Offline risred1

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Re: Boosted reyataz / truvada regimen - when do people take theirs?
« Reply #10 on: July 19, 2009, 02:20:52 PM »
I take my combo in the morning with breakfast.

Full Nutritious meal is vague.

If you look at the guidelines published on Aids Meds, it says Light meal.

The point is that the stomach needs to be producing acid for the Reyataz to work best.

I eat about a 500-600 calorie breakfast, which usual is some kind of bread,

for example an english Muffin, with Peanut Butter (2tbs), and 1/2 of a 10oz Yogurt smootie, 115 calories. (Stoney Brook Farms, strawberry smoothie.)

I discussed with the doctor and his opinion is that is fine.

I also may have some coffee, and if I'm pressed, take my fiber/glutamine drink with supps at the same time as well.

Morning is best for me, which is why I went with PI based instead of Atripla at bedtime.
risred1 - hiv +
02/07 CD4 404 - 27% - VL 15k
10/07 CD4 484 - 31% - VL 45k
05/08 CD4 414 - 26% - VL 70k
01/09 CD4 365 - 23% - VL 65k
05/09 CD4 291 - 23% - VL 115k - Started Meds - Reyataz/Truvada
06/09 CD4 394 - ?% - VL 1200 - Boosted Reyataz with Norvir and Truvada
07/09 CD4 441 - ?% - VL 118 - Boosted Reyataz with Norvir and Truvada
09/09 CD4 375 - ?% - VL Undetectable - Boosted Reyataz with Norvir and Truvada
12/09 CD4 595 - ?% - VL Undetectable - VIT D 34 - Reyataz/Truvada/Norvir

Offline Inchlingblue

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Re: Boosted reyataz / truvada regimen - when do people take theirs?
« Reply #11 on: July 19, 2009, 03:34:57 PM »
If you look at the guidelines published on Aids Meds, it says Light meal.


I agree it's vague but it doesn't say "light meal," at least not under the guidelines for Reyataz.

from aidsmeds:

Reyataz should be taken with food, preferably a complete nutritious meal, to ensure proper absorption of the drug into the bloodstream.

http://www.aidsmeds.com/archive/Reyataz_1563.shtml

Online Miss Philicia

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Re: Boosted reyataz / truvada regimen - when do people take theirs?
« Reply #12 on: July 19, 2009, 04:27:38 PM »
I agree it's vague but it doesn't say "light meal," at least not under the guidelines for Reyataz.

from aidsmeds:

Reyataz should be taken with food, preferably a complete nutritious meal, to ensure proper absorption of the drug into the bloodstream.

http://www.aidsmeds.com/archive/Reyataz_1563.shtml

Perhaps it's not up to date, as the actual Reyataz web site says that a light snack suffices

http://www.reyataz.com/hiv-medication.aspx

And a  6/18/09 FDA update states that the insert has results of a food effect study of a light meal vs. high fat meal:

http://www.fda.gov/ForConsumers/ByAudience/ForPatientAdvocates/HIVandAIDSActivities/ucm124020.htm
"Iíve slept with enough men to know that Iím not gay"

Offline bocker3

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Re: Boosted reyataz / truvada regimen - when do people take theirs?
« Reply #13 on: July 19, 2009, 05:14:37 PM »
I take my Reyataz with breakfast -- usually cereal and fruit (banana, blueberries, etc).  I take my Atripla in the evening.  I tried doing them all together at night, but hated to "have to eat" a snack before bed, so switched to breakfast.
I've been told all along by my doctor (as well as the Reyataz website) that a meal or snack was sufficient.

I always thought that it was not the FOOD, per se, that was important but that it was the stomach acid -- perhaps I'm wrong, but I thought this was why acid blockers are a no-no close to dosing time.  Food just insures that there is stomach acid there.......

Mike
Atripla - Started 12/05
Reyataz/Norvir - Added 6/06
Labs - Pre-Meds
Sep05 T=350/25% VL98,559
Nov05 288/18%  47,564
Current Labs
May2013 691/31% <20

Offline risred1

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Re: Boosted reyataz / truvada regimen - when do people take theirs?
« Reply #14 on: July 19, 2009, 05:45:25 PM »
http://www.aidsmeds.com/articles/DrugChart_10632.shtml

In this drug description from AIDS MEDS it says "light meal", which is inconsistent with the other posting about the guidelines.

Whatever... the point is that it is actually, in my opinion, insufficient as terms depend on our interpretation.

What is a "complete Nutritious Meal"? What is a "light meal"? your interpretation can be clearly different from mine.

What I draw from this is that there is "allowed" variability of opinion. All we apparently have to do is insure  our stomachs are acid enough for the reyataz to work.

What does that take? According to my doc, as long as the blood tests show effectiveness, manipulation of how we take Reyataz doesn't really need to be looked at. There are apparently ways to "tune" what and when you eat if that looks like an issue.

risred1 - hiv +
02/07 CD4 404 - 27% - VL 15k
10/07 CD4 484 - 31% - VL 45k
05/08 CD4 414 - 26% - VL 70k
01/09 CD4 365 - 23% - VL 65k
05/09 CD4 291 - 23% - VL 115k - Started Meds - Reyataz/Truvada
06/09 CD4 394 - ?% - VL 1200 - Boosted Reyataz with Norvir and Truvada
07/09 CD4 441 - ?% - VL 118 - Boosted Reyataz with Norvir and Truvada
09/09 CD4 375 - ?% - VL Undetectable - Boosted Reyataz with Norvir and Truvada
12/09 CD4 595 - ?% - VL Undetectable - VIT D 34 - Reyataz/Truvada/Norvir

Offline antibody

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Re: Boosted reyataz / truvada regimen - when do people take theirs?
« Reply #15 on: July 19, 2009, 08:28:31 PM »
whenever i eat my first meal. it does vary on occasion sometimes i work an earlier shift and might take it 3 hours early one day. Sometimes it's a big meal sometimes it's just a granola bar just to get it out of the way. I don't really worry about it and I have always been undetectable.
Timbuk      <50/ 794  CD4 10/06 
                 <50/ 1096 CD4 3/07
                 <40/ 1854 CD4 4/09

Started Atripla  7/14/06
Switched to boosted Reyataz Truvada 3/28/07

*Ask me about Medical Marijuana and how it can help you!*

Offline newt

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Re: Boosted reyataz / truvada regimen - when do people take theirs?
« Reply #16 on: July 19, 2009, 08:42:06 PM »
This food thing fucks me off

For one, a light snack and nutirious meal is in the ey of the beholder.  You have to go back to the original studies to find out what this means. For tenofovir (therefore truvada) it was a full-on eat-what-you-like burger buffet by the looks of things, for Reyataz it was, more or less, the average contents of a milk-based protein drink.

The important thing with Reyataz is some food for acid stomach (excuse for cola or coffeee but orange juice is heathy eh?) and some fat (esp for the norvir booster) (excuse for ice cream), for tenfovir, some food, preferably more, or else you fart til kingdom comes, plus food = better drug quantities into the body.

- matt
"The object is to be a well patient, not a good patient"

Offline risred1

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Re: Boosted reyataz / truvada regimen - when do people take theirs?
« Reply #17 on: July 20, 2009, 09:59:22 PM »
You know, that is great information....

I had no idea, and of course I'm not told that these different meds really have different profiles for the type of meal you should be looking at.

So according to what you wrote...

I have carbs in the bread, peanut butter for fat, and about 115 calories of Yogurt Drink.

All that is missing is the 1/3 lb. burger grilled, topped with cheese, bacon, fried onions, lettuce, a ripe tomato with mayo on the bottom roll, peppered of course, and a nice brown mustard...

then run about 10 miles!

 ;)
risred1 - hiv +
02/07 CD4 404 - 27% - VL 15k
10/07 CD4 484 - 31% - VL 45k
05/08 CD4 414 - 26% - VL 70k
01/09 CD4 365 - 23% - VL 65k
05/09 CD4 291 - 23% - VL 115k - Started Meds - Reyataz/Truvada
06/09 CD4 394 - ?% - VL 1200 - Boosted Reyataz with Norvir and Truvada
07/09 CD4 441 - ?% - VL 118 - Boosted Reyataz with Norvir and Truvada
09/09 CD4 375 - ?% - VL Undetectable - Boosted Reyataz with Norvir and Truvada
12/09 CD4 595 - ?% - VL Undetectable - VIT D 34 - Reyataz/Truvada/Norvir

Offline Dennis

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Re: Boosted reyataz / truvada regimen - when do people take theirs?
« Reply #18 on: July 21, 2009, 11:56:49 PM »
I personally have never worried about this. Originally, the first few years, I was taking my meds at bedtime, which would vary between 10pm and 1am; way past my last meal of the day. I just recently switched, and now take them in the morning. Sometimes with breakfast and sometimes without. Depends how rushed I am to get out the door. More often than not, it's just with a cup of coffee and a few rugula. I've Been undetectable except for a few months in 2008 when I was not taking my meds. As soon as I restarted, I was undetectable within the month.

Offline weasel

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Re: Boosted reyataz / truvada regimen - when do people take theirs?
« Reply #19 on: July 23, 2009, 09:31:08 AM »
I have always   ( 4 years ) ,  taken my meds with breakfast .

 I eat  yummy stuff , pizza , lasagna , leftover intipasta . spaghetti & meat balls

  ham and cheese sandwich , Chicken devan'.

  I have stayed with morning meal , very easy for me , the side effects wear off in a couple

  of hours and i am ready to go , or not  :(

  Anyway  Morning works well , and I eat like a hog in heaven !

                                              be good ,  take your pills when it is good for you .

                                                                                      Carl

                                                       
" Live and let Live "

Offline subaruturbo

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Re: Boosted reyataz / truvada regimen - when do people take theirs?
« Reply #20 on: August 07, 2009, 01:50:40 AM »
I started on that combination about a little less than two months ago. I take them between 12:30pm and 1:00pm in the afternoon seems to work for me. Thats when I eat the biggest meal and sometimes the only meal I eat. I have to watch what I eat fast food is not a good thing. I get alot of indegestion and gas from the combo if I get sick its in the wee hours of the morning because the medications didn't properly digest. Now doing a lot better. pepto and rolaids are my friends. Gas what the heck I laugh when I rip a few off no need to be shy. three pills once a day very nice taken alot of combo therapies. one month went from 15 cd4s to 136 vl from 127k to less than 75. Even found out am I pre-diabetic now on metformin twice day. Smoke like a chimney too, giving up very soon. terrible when you hack in the morning. my main concern is weight loss went from 130lbs to 114lbs not good but feeling great. As far as taking meds golden rule don't skip doses and take on time everyday. when you take them should fit your lifestyle. Night owl here up all night and all day.

Offline jay195

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Re: Boosted reyataz / truvada regimen - when do people take theirs?
« Reply #21 on: August 15, 2009, 06:24:24 PM »
I take my meds reyataz norvir and truvada after breakfast. I have a toasted soya bread bun with fresh garlic lightly rubbed in to it then fresh tomato pulp put on top of that and to finish off a light coatimg of olive oil and a wee touch of salt. I live in Spain and this is a typical Spanish brekkie. This  is accompanied by a mug of green tea. This is also the time when I take my fish oil capsules .Then off to the gym for my spinning class.No side affects.
                                                        Jay
                                                                                                                     

Offline Rayray

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Re: Boosted reyataz / truvada regimen - when do people take theirs?
« Reply #22 on: August 23, 2009, 05:01:15 AM »
I have been on the same combo as you for two years now you can see from my numbers that I'm telling the truth when i say I Have only been drinking a cup of coffee in the am with my pills and feel fine no side effects as stated with the gas and other problems.And My ID says keep doing whatever it is I'm doing b/c its working been undetectable for over a year now and feeling better then ever before,I'm not saying this works for everyone but for me it works everyday at 8:30am take the pills and go on about my day. all blood work comes back better everytime I go in so something is working.
Tested feb 2007 neg
Seroconvert 07/2007
Diagnosed w/ Aids-PCP-Mac-Thrush-PN
09/07 CD4 71 Put on zidovudrine, Efarivnz, prednisone,bactrim ds,Z pak,Diflucan,Mepron
10/07 CD4 9 160,000,000  Stopped all pre meds for observations found current ID. started on Atripila for two weeks end due to sustiva allergy
11/07 CD4 4 VL-1600,000start Norvir-Truvada-Reytaz
12/07 CD4 83 VL-1600,000
02/08 CD4 488 VL- 4100
05/08 CD4 514 VL- 4200
07/08 CD4 434 VL- <400
10/08 Cd4 531 VL-Undetectable
10/16/2008 cd4 393 VL-undetectable
01/29/2009 cd4 419 VL-undetectable
04/28/2009 cd4 385 VL-undetectable
08/06/2009 cd4 358 VL-undetectable
12/14/2010 cd4 741 VL-undetectable

 


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