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Author Topic: HIV - Ideas for a functional cure  (Read 2308 times)

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Offline John2038

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HIV - Ideas for a functional cure
« on: November 04, 2008, 10:37:36 AM »
Any ideas for a functional cure ?
Below mine. Feasible, realistic or ?

1) Annihilation of the virus

Some virus are recombinant. Eg AE
As far as I know, E have never been isolated.

Is it so possible to create in a laboratory another subtype of virus (let say X) that when recombined, produce an inoffensive recombinant virus, for eg XC, and maybe replacing C (as for E above) ?

2) Annihilation of the mutations

- coinfection   :  seroconverting with 2 strains of virus (eg subtypes B & C)
- superinfection : infection with B then (after seroconversion) with C (for e.g)

It seems that in the case of superinfection, the oldest clade disappear (and its mutations) and is replaced by the newest clade.

Can someone confirm ?

Could this observation lead to a functional cure ? for example, by superinfecting someone with the subtype A (for eg, as less virulent), to erase the existing and more virulent subtype and /or its mutations.
« Last Edit: November 05, 2008, 11:29:01 AM by John2038 »

Offline John2038

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Re: Super naive idea for a functional cure
« Reply #1 on: November 04, 2008, 10:47:03 AM »
.
« Last Edit: November 04, 2008, 11:17:54 AM by John2038 »

Offline John2038

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Re: HIV - Ideas for a functional cure
« Reply #2 on: March 04, 2009, 12:49:17 PM »
Im not looking to just put this post up, but I am really wondering.

Can we modify artificially (like a lentiviral vector) a HIV strain so that once recombined with a targetted strain will result in an innoffensive recombinant ?

Indeed, we knows that the virus might be recombinant (e.g. AE):
Eg. the strain A and E have recombine to give the so called strain E but without any more traces of E.

So why not trying to recombine let say C and X so CX is innoffensive or let say much less virulent.

Any insights very welcome.
« Last Edit: March 05, 2009, 01:07:30 PM by John2038 »

Offline hahaha

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Re: HIV - Ideas for a functional cure
« Reply #3 on: March 05, 2009, 12:32:02 AM »
Im not looking to just put this post up, but I am really wondering.
Can we modify artificially (like a lentiviral vector) a HIV strain so that once recombined with the strain existing in someone infected become innoffensive ?

I thought that Virxsys 496 have similar idea.
It actually use HIV virus delete certain gene and incorporate a counter-sequence gene. (let us call it HIV*)
HIV in a broad definition, shall be a lentiviral vector itself.
The only difference is that HIV meet HIV* does not create a new "virus" rather, it neutralize certain part of RNA produced.
I recall some report saying that, once HIV meet HIV*, HIV will automatically delete its corresponde gene and created an much harmless HIV**.

Isn't it just similar to what you say, a "recombined" strain?

I think that Virxsys does not use TAT in their HIV* is due to safety concern.     
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Offline John2038

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Re: HIV - Ideas for a functional cure
« Reply #4 on: March 05, 2009, 01:30:00 PM »
Thanks for your reply

If the initial concept is the same, the way it works is different.

With the VRX496, the DNA of the patient is altered to include the RNA delivered by VIRxSYS.
So indeed, when the virus deliver his own RNA, the result (original DNA + VRX496 RNA + HIV RNA) is suppose to produce new virus unable to replicate efficiently or not at all.

The idea here is a bit different but I agree, very similar also:
The idea here is to create a new virus and to anihilate the host more virulent host virus.
So the new recombinant virus still exists, but the hopes is that it is no more harmful.

I think the main difference is in the concept.
But the result is the same : 2xRNA + host DNA

No ?

 


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