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Author Topic: GI difficulties after switching to Prezista/Norvir  (Read 1622 times)

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Offline jjmcm

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  • Posts: 78
GI difficulties after switching to Prezista/Norvir
« on: February 08, 2009, 12:49:41 PM »
Three months ago, I swapped the Kaletra/Invirase in my regimen for Prezista and the old Norvir capsule which I had not been on for three years.  My regimen with Kaletra/Invirase still worked fine, my doctor and I were trying to simply things and make the move before I became resistant to Kaletra.  I also take Isentress and Truvada.

While my labs have stayed level, undetectable and CD4's - 350-450, I started experiencing abdominal pain at week three.  At week five, I was forced to stop taking some of my supplements that I felt could aggravate potential digestive issues.  At week eight, shortly after Christmas, I started getting constipated for the first time in my life.

I normally eat well, but was forced to make additional reductions in fat, sugar to my diet.  A month ago I had to add a nightly probiotic, fiber, and digestive enzymes to make sure I could go BM once per day.   Last week, I went in to see my doctor because the pain has become unbearable and I was not sleeping.  I have lost 15 pounds during the last three months.

My doctor seems to think the long term use of nukes has caused a deterioration of my nerves in my GI track and causing irregularity and pain.  He sent out stool sample for testing for parasites, etc. , tested for h. pylori, and sent me for a CAT scan to make sure I did not have a tumor growing inside of me.  All these have, so far, come back negative.

I see a gastroenterologist on Tuesday to get his take on all this.  Meanwhile my doctor has taken off for the CROI conference in Montreal returning Friday.  He wants me to stay on my current meds until he returns.

I believe this started happening right after the switch from Kaletra/Invirase to Prezista and the Norvir capsule.  As you all know, the Kaletra tablet has the new version of Norvir co-formulated with it.  Abbot is at the FDA right now trying to get the new tablet version of Norvir approved.  If I had it right now, I would try it to see if my symptoms resolve.  Otherwise, I feel I will be forced to go back on the Kaletra/Invirase to see if the severe abdominal pain will go away.

Has anyone else had difficulties after switching from the Kaletra tablet back to Prezista or a regimen requiring the old Norvir capsule?  It sure would make my task easier with convincing my doctor.

He is talking about swapping out the Truvada for Intelence while I am still in terrible pain and subjecting me to new side effects.  I don't think that will help do anything to resolve this problem and might increase my weight loss.  I need to turn this around.

Please let me know if you have had any similar issues.


« Last Edit: February 08, 2009, 12:55:20 PM by jjmcm »

Offline veritas

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Re: GI difficulties after switching to Prezista/Norvir
« Reply #1 on: February 08, 2009, 01:29:55 PM »


I'm on the same regimen as you. I have been on this combination for over a year now. The only side effect that I have experienced is bone loss due to the viread. The Norvir used to cause me the big D when I was taking it with Tipranavir but that was twice the dose than what we are taking with Prezista.
I have heard that some patients cannot take Norvir at all. Even a small dose causes problems. Especially stomach issues.

It's good that your seeing a gastroenterologist next week. I hope he finds the culprit.

Good Luck,



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