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Author Topic: Ever had to change meds because of fatigue?  (Read 1400 times)

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Offline todd123

  • Member
  • Posts: 67
  • "You don't ask, you don't know."
Ever had to change meds because of fatigue?
« on: January 26, 2009, 08:33:55 PM »
Hey all.
For the past 10 days I've had this severe fatigue accompanied by fevers and night sweats in evening.
I just thought I had caught a bad cold/flu bug.  Saw the doc last week (Tuesday 3days into it).
It was a scheduled blood draw for labs.
I spoke with him this afternoon and although he didn't have my labs right in front of him (his assistant had left for the day).  He didn't recall anything being out of the ordinary and that there
was even a drop in VL.  So, clearly the meds are working.  His concern was that a flu like bug usually starts to resolve these major issues within the week.. He was wondering if it was starting to be a side
effect of my meds(prezista/norvir,isentress, intelence).  As u can see my numbers are still in the danger zone.
I'm wondering if anyone else has ever had to swtich a totally successful med regime simply because of these kinds of symptoms.  It's only been 7 months.  And I'd really rather not.

anxiously awaiting,
Scott
Tested HIV+ July 28, 2008
CD4 16 VL over 400,000
Started Prezista/Norvir, Isentress and Intelence; Mepron
8/08   CD4 64    2%      VL 1500
9/08   CD4 135  6%      VL 371
11/08 CD4 104   9%     VL 156
12/08 CD4 161   9%     VL 400
01/09 CD4 109   7%     VL 351
02/09 CD4 218   8%     VL   98
03/09 CD4   80   5%     VL   98 at least that's the same
04/09 CD4 150   7%      VL 100
05/09 CD4 232   8%      VL   90

Offline aztecan

  • Member
  • Posts: 5,399
  • 29 years positive, 57 years a pain in the butt
Re: Ever had to change meds because of fatigue?
« Reply #1 on: January 27, 2009, 12:22:08 AM »
Hey Todd,

Every time I have switched meds, it was because of side effects, not resistance.

For some of us Hi-fivers, fatigue just comes with the territory. But there are some meds which may induce the feelings of fatigue or of being run down.

I have never taken any of the meds your are on, save Norvir, so I can't comment on whether any of them heightened my feelings of fatigue.

Just curious, what meds have you been on in the past? Could any of them have set the stage for this fatigued, run-down feeling?

For the record, I always try to give any med at least a two-month trial before making any decisions. That is no guarantee, but it seems to help get past any initial side effects.

HUGS,

Mark

« Last Edit: January 27, 2009, 12:27:35 AM by aztecan »
"May your life preach more loudly than your lips."
~ William Ellery Channing (Unitarian Minister)

Offline todd123

  • Member
  • Posts: 67
  • "You don't ask, you don't know."
Re: Ever had to change meds because of fatigue?
« Reply #2 on: January 27, 2009, 12:48:32 AM »
Well that's the thing.  These are the ONLY meds I've been on.  And it's only been a problem starting about 10 days ago.  I've actually been on these for a little over 6 months with no problems.

It's not definite yet that the problem is the meds.  My doctor just mentioned it and because I'm a newbie, I just got scared about shifting.  Because I showed up with a full blown AIDS diagnosis coupled with my very low tcells and VAST sexual acting out, my doctor took a radical approach and put me on the newest stuff right away.  He felt there was a good chance that I had already been exposed to some multi-strains and didn't feel
we had time to wait on the 3 week resistance test.  So basically, I'm feeling like a guinea pig here.
There ARE other symptoms. Fever of about 101 usually only at night.  About 2 to 3 major night sweats each night for the last 10days.  And really bad body and muscle aches which tylenol , advil, and hot baths seem to help.
Just not sure how long to let it run this course before switching.  I'm convinced it could ALSO be any number of other infections.

Just anxious that's all.  How many times have you changed?

By the way, I am always moved and grateful by the support you offer to soooo many people on here.
I , for one, really do appreciate it.

best,
Scott
Tested HIV+ July 28, 2008
CD4 16 VL over 400,000
Started Prezista/Norvir, Isentress and Intelence; Mepron
8/08   CD4 64    2%      VL 1500
9/08   CD4 135  6%      VL 371
11/08 CD4 104   9%     VL 156
12/08 CD4 161   9%     VL 400
01/09 CD4 109   7%     VL 351
02/09 CD4 218   8%     VL   98
03/09 CD4   80   5%     VL   98 at least that's the same
04/09 CD4 150   7%      VL 100
05/09 CD4 232   8%      VL   90

Offline aztecan

  • Member
  • Posts: 5,399
  • 29 years positive, 57 years a pain in the butt
Re: Ever had to change meds because of fatigue?
« Reply #3 on: January 27, 2009, 01:11:29 AM »
Hey Scott,

Well, I've only changed five times. I know that sounds like a lot, but, let me explain.

I started out with AZT, 3TC (Epivir), and Saquinavir. The original Saquinavir was really nasty stuff. I turned into the Hindenburg, a big bag of gas ready to explode without warning that soon became uncontrollable diarrhea.
(I learned a lot about exercising my butt cheek squeeze control in those days!  :D)

After about two months of that, I switched to Crixivan. I know a lot of people had trouble with Crixivan, especially with the requirement it had to be taken every eight hours - on time and on an empty stomach. I actually did very well with it and took it, along with the AZT and 3TC for 11 years.

The only side effect I noticed early on were the anemia caused by the AZT and the kidney stones caused by the Crixivan. Nothing too severe, but, at times, bothersome.

I then developed a buffalo hump and Crix belly, so I switched to Combivir (same thing as AZT and 3TC, except in one pill) and Sustiva. EEEP! Not pretty!  The doctor said I had the worst side effects he had ever seen with Sustiva.

So, after about two months enduring that medication, (which I only survived thanks to the great support I got here, from my friends and at my workplace), I switched to Reyataz/Norvir and Combivir. Loved it, but I suffer from GERD and my acid reflux got so bad I had to switch.

So, I am now on Lexiva, boosted with Norvir, and Combivir.

This March, I will have been on meds for 13 years. Not too bad.

Has your doctor checked other things aside from your viral load and CD4s, and the other usual bloodwork like CBC, etc?  I ask because I felt something like you describe and my problem stemmed from using a statin, a medication used to fight cholesterol, with a protease inhibitor.

I was just wondering if there are other drugs, or even herbs or complementary therapies, in the mix and whether they might not be causing you problems.

In other words, just being nosy!  ;)

I hope you get to the bottom of this. Keep us posted on how things go.

HUGS,

Mark

« Last Edit: January 27, 2009, 01:21:06 AM by aztecan »
"May your life preach more loudly than your lips."
~ William Ellery Channing (Unitarian Minister)

Offline todd123

  • Member
  • Posts: 67
  • "You don't ask, you don't know."
Re: Ever had to change meds because of fatigue?
« Reply #4 on: January 27, 2009, 12:50:03 PM »
Thanks Mark. I will.  I want to stay on these as long as possible.
Talking to him today.  I've not really come along anyone with my particular combo
and combo of side effects.  I'm frustratingly in the dark.

best
Scott
Tested HIV+ July 28, 2008
CD4 16 VL over 400,000
Started Prezista/Norvir, Isentress and Intelence; Mepron
8/08   CD4 64    2%      VL 1500
9/08   CD4 135  6%      VL 371
11/08 CD4 104   9%     VL 156
12/08 CD4 161   9%     VL 400
01/09 CD4 109   7%     VL 351
02/09 CD4 218   8%     VL   98
03/09 CD4   80   5%     VL   98 at least that's the same
04/09 CD4 150   7%      VL 100
05/09 CD4 232   8%      VL   90

Offline todd123

  • Member
  • Posts: 67
  • "You don't ask, you don't know."
Re: Ever had to change meds because of fatigue?
« Reply #5 on: January 27, 2009, 05:22:39 PM »
Hey Mark,

Just wanted to give an update.  Just spoke with my doc and he is referring me to an ID specialist.
On my last labs my VL dropped but so did my cd4's.  Quite a bit from 161 to 109.  Now I was not feeling well
at the time of the test, so I expected some drop-this much was a little disappointing.

He also said that the drop probably has nothing to do with HIV but is related to something else.
Because my VL also dropped the meds are clearly working. My CD4's are fighting something.  We just don't know what

On the good news front: no HepC exposure and I'd already been vaccinated for the A & B.

I'll let you know more, when I know more.

best,
Scott

Tested HIV+ July 28, 2008
CD4 16 VL over 400,000
Started Prezista/Norvir, Isentress and Intelence; Mepron
8/08   CD4 64    2%      VL 1500
9/08   CD4 135  6%      VL 371
11/08 CD4 104   9%     VL 156
12/08 CD4 161   9%     VL 400
01/09 CD4 109   7%     VL 351
02/09 CD4 218   8%     VL   98
03/09 CD4   80   5%     VL   98 at least that's the same
04/09 CD4 150   7%      VL 100
05/09 CD4 232   8%      VL   90

 


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