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Author Topic: Different HIV clades, different Tat, very different dementia rates  (Read 1949 times)

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Offline leit

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A link between Tat (of clade B of HIV-1, which the majority of researchers usually base their studies on) and dementia has already got several confirmations.
This new study, showing that clade C Tat causes far lower neurological damages than clade B Tat, seems to me a very strong corroboration of the role of the latter in causing the so called "HIV dementia", that might so more precisely be a "clade B HIV-1 dementia".


Offline emeraldize

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Re: Different HIV clades, different Tat, very different dementia rates
« Reply #1 on: December 06, 2008, 07:59:29 AM »
Hi Leit,

This is an interesting study. I am wondering if the author made a mistake in writing the release, or, I'm not picking something up. Note the following excerpt:

The next step, and the focus of the current study, was to compare the two viruses in a single host to determine whether this key change in the amino acid sequence makes a practical difference in HIV's neurotoxicity.

To find out, the researchers injected either clade B or clade C HIV into the brain of a special strain of immunodeficient mice. After six days--enough time for the viruses to cause neurologic damage--the mice were tested in a complex water maze that challenged their long term memory as well as their short term working memory (the type that temporarily stores and manages the information needed to carry out complex cognitive tasks, such as learning, reasoning, and comprehension).

Mice infected with clade B performed significantly worse in the maze than those infected with clade C.

What's throwing me (in bold) is that it's written they would compare the Clades in a single host, but in fact they compare them, understandably, in separate hosts and compare their performances in maze testing. This is a very prestigious institution and I'm surprised it's written this way, or, there's something I'm not picking up.

If you or anyone else see this differently, please let me know.

Despite this glitch, it's fascinating research and I hope to read more about it.

Em

Offline Assurbanipal

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Re: Different HIV clades, different Tat, very different dementia rates
« Reply #2 on: December 06, 2008, 09:51:25 AM »
What's throwing me (in bold) is that it's written they would compare the Clades in a single host, but in fact they compare them, understandably, in separate hosts and compare their performances in maze testing. This is a very prestigious institution and I'm surprised it's written this way, or, there's something I'm not picking up.

I think that "host" often refers to a species rather than to individual members of the species in biological writing. 

"Biology The animal or plant on which or in which another organism lives.  "
http://education.yahoo.com/reference/dictionary/entry/host

At least that's my vague recollection from a genetics course a long time ago.

Regards
A

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Offline Ann

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  • It just is, OK?
    • Num is sum qui mentiar tibi?
Re: Different HIV clades, different Tat, very different dementia rates
« Reply #3 on: December 06, 2008, 10:54:37 AM »
What I want to know is how does one discover what clade they have?
Condoms are a girl's best friend

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"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline emeraldize

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Re: Different HIV clades, different Tat, very different dementia rates
« Reply #4 on: December 06, 2008, 12:09:12 PM »
Assurbanipal - Thanks. THAT makes sense.

Ann - When I had genotyping done the clade was revealed.

Offline leit

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Re: Different HIV clades, different Tat, very different dementia rates
« Reply #5 on: December 07, 2008, 10:11:17 AM »
I am wondering if the author made a mistake in writing the release, or, I'm not picking something up.

Hi "emeraldize"!

I believe "Assurbanipal" is right.


Offline emeraldize

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Re: Different HIV clades, different Tat, very different dementia rates
« Reply #6 on: December 07, 2008, 11:44:15 AM »
Yes, thanks to both of you. I appreciate the feedback very much.

Offline RapidRod

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Re: Different HIV clades, different Tat, very different dementia rates
« Reply #7 on: December 07, 2008, 08:55:18 PM »
Ann, subtypes and clades are the same.

Rodney

 


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