Quantcast

Subscribe to:
POZ magazine
E-newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join
Username:
Password:
Welcome, Guest. Please login or register.
April 20, 2014, 07:28:42 AM

Login with username, password and session length


Members
Stats
  • Total Posts: 620460
  • Total Topics: 46751
  • Online Today: 191
  • Online Ever: 585
  • (January 07, 2014, 02:31:47 PM)
Users Online
Users: 5
Guests: 137
Total: 142

Welcome


Welcome to the POZ/AIDSmeds Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ/AIDSmeds community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Guidelines Prediction: Start Treatment Earlier  (Read 1422 times)

0 Members and 1 Guest are viewing this topic.

Offline Peter Staley

  • Member
  • Posts: 1,337
  • Founder & Advisory Editor, AIDSmeds.com
    • AIDSmeds.com
Guidelines Prediction: Start Treatment Earlier
« on: October 27, 2008, 02:22:56 PM »
I've got a new blog posting about the never-ending debate on when to start treatment:

http://blogs.poz.com/peter/archives/2008/10/guidelines_pred.html

If you leave a comment here, please cut & paste it below this blog entry as well.

Thanks for reading!

Peter

Offline stratosphere

  • Member
  • Posts: 61
Re: Guidelines Prediction: Start Treatment Earlier
« Reply #1 on: October 27, 2008, 08:52:33 PM »
pretty soon there will be a statistic that tells us to start taking meds before we are even infected,  or has that happened yet?
  ;)

(thats a joke btw)

Cheers

 :)
1/05   CD4 305  VL  ?        34%
2/05   CD4 310  VL  ?        35%
7/05   CD4 277  VL  <50    43%
11/05 CD4 516  VL  <50    46%
2/06   CD4 640  VL  <50    46%
6/06   CD4 578  VL  <50    46%
10/06 CD4 491  VL  <50    50%
3/07   CD4 674  VL  <50    50%
7/07   CD4 516  VL  <50    43%
11/07 CD4 635  VL  <50    44%
3/08   CD4 584  VL  <50    48%
7/08   CD4 510  VL  <50    49%
11/08 CD4 580  VL  <50    49%
2/09   CD4 661  VL  <50    50%

Offline denb45

  • Member
  • Posts: 5,051
  • "1987 Classic Old School POZ+"
Re: Guidelines Prediction: Start Treatment Earlier
« Reply #2 on: October 27, 2008, 10:02:24 PM »
pretty soon there will be a statistic that tells us to start taking meds before we are even infected,  or has that happened yet?
  ;)

(thats a joke btw)

Cheers

 :)

LOL, I didn't start meds until 91, it's 2008 now, guess I would have been DEAD if I didn't start Meds back then, but, that's a tough call tho? and very hard to prove?  ???
"it's so nice to be insane, cause no-one ask you to explain" Helen Reddy cc 1974

Offline blondbeauty

  • Member
  • Posts: 1,785
Re: Guidelines Prediction: Start Treatment Earlier
« Reply #3 on: October 28, 2008, 07:29:38 AM »
I decided to start meds when my CD4s were 503 because I am witch that can predict the future...
The only member in these forums approved by WINBA: World International Nail and Beauty Association.
Epstein Barr +; CMV +; Toxoplasmosis +; HIV-1 +.
Counts when starting treatment:
V.L.:80.200 copies. CD4: 25%=503
Started Sustiva-Truvada 14/August/2006
Last V.L.count (Oct 2013): Undetectable
Last CD4 count (OCT 2013): 52%= 933

Offline bufguy

  • Member
  • Posts: 159
Re: Guidelines Prediction: Start Treatment Earlier
« Reply #4 on: October 28, 2008, 03:19:55 PM »
My Doc started me recently with a CD4 of 511. I was a little hesitant at first, but he knew I was motivated and educated and would be adherent. Its only been 5 months, but numbers are great and I feel great. I feel that I'm doing something and taking control.
5/29/08 confirmed HIV+
6/23/08 Vl 47500  CD4 511/29% CD8 .60
start atripla
8/1/08 Vl 130  CD4 667/31% CD8 .70
9/18/08 Vl un  CD4 not tested
12/19/08 Vl un CD4 723/32% CD8 .80
4/3/09 Vl un CD4 615/36% CD8  .98
8/7/09 vl un CD4 689/35% CD8 .9
12/11/09 vl un CD4 712/38% CD8 .89
4/9/10 vl un CD4 796/39% CD8 1.0
8/20/10 vl un CD4 787/38% CD8 1.0
4/6/10 vl un CD4 865/35% CD8 .9
8/16/10 vl un CD4 924/37% CD8 1.0
12/23/10 vl un CD4 1006/35% CD8 .9
5/2/10 vl un CD4 1040/39% CD8 .9
8/7/13 vl un CD4 840/39% CD8 .9

Offline madbrain

  • Member
  • Posts: 1,208
  • No longer an active member
    • My personal site
Re: Guidelines Prediction: Start Treatment Earlier
« Reply #5 on: October 29, 2008, 03:36:16 AM »
pretty soon there will be a statistic that tells us to start taking meds before we are even infected,  or has that happened yet?
  ;)

(thats a joke btw)

Cheers

 :)

It's not even a joke !

We may end up having the "evening before" pill for HIV.

http://www.cdc.gov/hiv/resources/qa/prep.htm

Offline Miss Philicia

  • Member
  • Posts: 23,565
  • celebrity poster, faker & poser
Re: Guidelines Prediction: Start Treatment Earlier
« Reply #6 on: October 29, 2008, 11:07:40 AM »
One must balance the point numerically about starting meds against the possibility of something like lipodystrophy.  That's one of the primary, if not THE primary, reasons that most patients put off going on HIV medications.  If this propensity towards mitochondria dysfunction did not exist certainly everyone would commence at 500 cd4 or so.  It's quite simple to see that it is this concern that everyone fixates on -- just look at the AM forums.

I find it somewhat disingenuous not to mention this, if it was indeed not, at this Boston conference.  However, I did not delve into the meeting minutes.  There is certainly no mention of this in the poz.com treatment news write up.

I will add though that with the present or expected approval of the most recently developed ARVs (Prezista, Isentress, and Selzentry) as "first time treatment" options (as opposed to only being approved for those with large resistance profiles) is encouraging, as these three meds are notably less prone to side effects and I believe that tests have exhibited them having a low mitochondrial/metabolic toxicity.
« Last Edit: October 29, 2008, 11:15:00 AM by philly267 »
"Iíve slept with enough men to know that Iím not gay"

Offline madbrain

  • Member
  • Posts: 1,208
  • No longer an active member
    • My personal site
Re: Guidelines Prediction: Start Treatment Earlier
« Reply #7 on: October 31, 2008, 07:37:17 PM »
That's one of the primary, if not THE primary, reasons that most patients put off going on HIV medications. 

Indeed, the possibility of side effects is a worry, especially over the long-term, for example if one is starting to take them while still healthy and young, since we don't really have a very long history of usage for many ARVs yet. There is of course also treatment access issues.

The former is the reason why I haven't started HAART, on the advice of my doc. The benefit of starting this early may be outweighed by side effects. Then again, it may not.

I haven't exactly figured out what my personal threshold will be for deciding to go on meds. I just know that I won't do it if the labs remain stable and I stay healthy. It sure is a hard decision to commit to meds when the labs still look good.

 


Terms of Membership for these forums
 

© 2014 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.