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Author Topic: Phosphorylated Acyclovir. Why so much excitement for a possible NRTI?  (Read 2180 times)

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Offline leit

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Phosphorylated Acyclovir, so what? I wonder why all Margolis' "discoveries" (valproic acid, LOL!) are so valued.


Offline Iggy

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Re: Phosphorylated Acyclovir. Why so much excitement for a possible NRTI?
« Reply #1 on: September 17, 2008, 11:19:18 AM »
Leit,

Why would you ask so what?  Just a gentle reminder of what you've been asked by Tim Horn:

http://forums.poz.com/index.php?topic=22999.msg294003#msg294003

Quote
Therefore, the first thing I'm going to request that you do is keep all of the comments you have about a particular research finding/hypothesis in one thread -- and be sure to write subject lines that CLEARLY spell out what, in fact, you're writing about (your subject lines are often vague and flip). The second thing I'm going to ask you to do is to take some time to spell out your comments and not simply post every little report elsewhere on the web that grabs your attention. If you're looking to foster communication in this Forum with others, consider by starting with a thoughtful and reasoned message.

Offline Finnboy

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Re: Phosphorylated Acyclovir. Why so much excitement for a possible NRTI?
« Reply #2 on: September 17, 2008, 11:42:14 AM »
Why so much excitement for a possible NRTI?

Because it may show potential as a very cheap 2nd line combo element for the developing world.

Offline Miss Philicia

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Re: Phosphorylated Acyclovir. Why so much excitement for a possible NRTI?
« Reply #3 on: September 17, 2008, 11:48:24 AM »
I fail to understand what leit is trying to accomplish with this thread (and many others frankly, but whatever).
"Iíve slept with enough men to know that Iím not gay"

Offline Tim Horn

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Re: Phosphorylated Acyclovir. Why so much excitement for a possible NRTI?
« Reply #4 on: September 17, 2008, 01:03:35 PM »
Leit:

I'd appreciate it if you'd ackowledge my post here: http://forums.poz.com/index.php?topic=22999.msg294003#msg294003

Yet again, you've posted a link and comment that lacks any sort of context. Keep this up and we'll be forced to corral your numerous posts into a single thread -- and request that you only post new topics there. 

As for your "so what," I encourage you to think about this. While this may not revolutionize HIV care in industrialized nations, generic acyclovir is dirt cheap... and compounded by its unique mechanism of action in HIV-positive people with herpes coinfection... it might make a HUGE difference in parts of the world where the novel therapies we enjoy here are not available.

Tim Horn
« Last Edit: September 17, 2008, 01:07:33 PM by Tim Horn »

Offline Assurbanipal

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Re: Phosphorylated Acyclovir. Why so much excitement for a possible NRTI?
« Reply #5 on: September 17, 2008, 01:52:50 PM »
... and the virtues of "dirt cheap" should not be underestimated for what they could potentially mean for governmental, health plan and individual purchasers.  Even if suitable for only a few people, if they replace a drug that's costing $10K per year, that can free up resources to deploy to other needs.  What's not to celebrate in the idea of an inexpensive new potential treatment for which (although there will still be plenty of testing to do) we already have a lot of safety data?  Even in the developed world that sounds like rather good news.

5/06 VL 1M+, CD4 22, 5% , pneumonia, thrush -- O2 support 2 months, 6/06 +Kaletra/Truvada
9/06 VL 3959 CD4 297 13.5% 12/06 VL <400 CD4 350 15.2% +Pravachol
2007 VL<400, 70, 50 CD4 408-729 16.0% -19.7%
2008 VL UD CD4 468 - 538 16.7% - 24.6% Osteoporosis 11/08 doubled Pravachol, +Calcium/D
02/09 VL 100 CD4 616 23.7% 03/09 VL 130 5/09 VL 100 CD4 540 28.4% +Actonel (osteoporosis) 7/09 VL 130
8/09  new regimen Isentress/Epzicom 9/09 VL UD CD4 621 32.7% 11/09 VL UD CD4 607 26.4% swap Isentress for Prezista/Norvir 12/09 (liver and muscle issues) VL 50
2010 VL UD CD4 573-680 26.1% - 30.9% 12/10 VL 20
2011 VL UD-20 CD4 568-673 24.7%-30.6%
2012 VL UD swap Prezista/Norvir for Reyataz drop statin CD4 768-828 26.7%-30.7%

Offline leit

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Re: Phosphorylated Acyclovir. Why so much excitement for a possible NRTI?
« Reply #6 on: September 17, 2008, 03:39:27 PM »

Yet again, you've posted a link and comment that lacks any sort of context.

Sorry, isn't this forum a "context" in itself? Research News & Studies Forum: This is a great place to discuss research news, including reports published by AIDSmeds.com and other media sources.

I posted a recent piece of news, I asked a question ("Why so much excitement?"), I got pertinent replies by "Finnboy", you and "Assurbanipal" (it's mostly a matter of cost).

What was wrong in that?


Offline Miss Philicia

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Re: Phosphorylated Acyclovir. Why so much excitement for a possible NRTI?
« Reply #7 on: September 17, 2008, 03:47:04 PM »

What was wrong in that?


Read the link Tim Horn provided and maybe you'll figure it out.
"Iíve slept with enough men to know that Iím not gay"

 


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