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Author Topic: Acyclovir -- One Reason Why I'm Still Alive?  (Read 1697 times)

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Offline Peter Staley

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Acyclovir -- One Reason Why I'm Still Alive?
« on: September 13, 2008, 11:12:49 AM »
See my latest blog posting on this fascinating new study:

http://blogs.poz.com/peter/archives/2008/09/acyclovir_one_r.html

If you comment here, please cut & paste your comment below my blog posting as well.

Thanks for reading!

Offline Jeff G

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Re: Acyclovir -- One Reason Why I'm Still Alive?
« Reply #1 on: September 13, 2008, 11:31:01 AM »
I wish they still made Zovirax cream . Once in awhile I get a cold sore that can become quite handsome . If I put Zovirax cream on at the first tingle that every one knows that's had a cold sore it will make it go away before it even turns red . 

Offline Finnboy

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Re: Acyclovir -- One Reason Why I'm Still Alive?
« Reply #2 on: September 13, 2008, 11:46:26 AM »
I wish they still made Zovirax cream .

They do here in the UK. I can send you a supply; but what is bootleg Zovirax worth to you?  :P

Offline Ann

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Re: Acyclovir -- One Reason Why I'm Still Alive?
« Reply #3 on: September 13, 2008, 11:50:50 AM »
Peter,

Earlier today I came across an article at Aidsmap on this same study. There are some additional facts in the Aidsmap version so it's worth having a look.

Herpes drug has direct anti-HIV effect, could offer cheap addition to antiretroviral therapy for developing world

Ann
Condoms are a girl's best friend

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"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline Jeff G

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Re: Acyclovir -- One Reason Why I'm Still Alive?
« Reply #4 on: September 13, 2008, 11:55:25 AM »
They do here in the UK. I can send you a supply; but what is bootleg Zovirax worth to you?  :P

I bet my American part d insurance isn't good in England  ;D

I rarely get the cold sores since I moved away from chicago to a warmer climate for some reason .
I take the pills if I have them if I feel one coming on , but they upset my tummy and don't seem to work as well for me .

Offline Jeff G

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Re: Acyclovir -- One Reason Why I'm Still Alive?
« Reply #5 on: September 13, 2008, 12:01:13 PM »
I may be wrong but I think my GP put me on Acyclovir along with AZT in the 80's .
He was and still is willing to go " off label " with meds if he thinks it may be beneficial .   

Offline edfu

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Re: Acyclovir -- One Reason Why I'm Still Alive?
« Reply #6 on: September 13, 2008, 10:16:46 PM »
Valaciclovir (Valtrex) is a pro-drug of acyclovir.  Does this study's ramifications also apply to it?

Valtrex is still proprietary, so it costs more than acyclovir, which is available generically. Its greatest asset is that it needs to be taken only once a day, whereas acyclovir needs to taken at least twice a day (for prophylaxis). 
"No one will ever be free so long as there are pestilences."--Albert Camus, "The Plague"

"Mankind can never be free until the last brick in the last church falls on the head of the last priest."--Voltaire

Offline Ann

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Re: Acyclovir -- One Reason Why I'm Still Alive?
« Reply #7 on: September 13, 2008, 10:22:18 PM »
whereas acyclovir needs to taken at least twice a day (for prophylaxis).

I take 400mgs once a day with no problems. With my doctor's blessings. It works for me and it's easy to check it out to see if it works for you as well.

Ann
Condoms are a girl's best friend

Condom and Lube Info  



"...health will finally be seen not as a blessing to be wished for, but as a human right to be fought for." Kofi Annan

Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline edfu

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Re: Acyclovir -- One Reason Why I'm Still Alive?
« Reply #8 on: September 13, 2008, 10:47:51 PM »
Thanks, Ann.  Obviously, that works OK for you.  I was simply pointing out the "standard recommended" prophylactic dosage, which is 400 mg. twice a day.  I was taking 400 mg. once a day, and when I changed doctors, the second doctor was horrified and told me that such a dosage could cause resistance to acyclovir.  Eventually, he recommended that I switch to Valtrex. 
"No one will ever be free so long as there are pestilences."--Albert Camus, "The Plague"

"Mankind can never be free until the last brick in the last church falls on the head of the last priest."--Voltaire

Offline Finnboy

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Re: Acyclovir -- One Reason Why I'm Still Alive?
« Reply #9 on: September 14, 2008, 02:05:34 AM »
Valaciclovir (Valtrex) is a pro-drug of acyclovir.  Does this study's ramifications also apply to it

Yes. By the time valaciclovir has been broken down by your body, the active ingredient that hits your bloodstream (and any herpesvirus-infected tissues) is still aciclovir; but at higher levels than would have been possible had you just swallowed aciclovir / acyclovir. The downside of that delivery method is that it can be harder on the kidneys.
« Last Edit: September 14, 2008, 02:23:25 AM by Finnboy »

Offline madbrain

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Re: Acyclovir -- One Reason Why I'm Still Alive?
« Reply #10 on: September 19, 2008, 08:06:40 PM »
Peter,

See my latest blog posting on this fascinating new study:

http://blogs.poz.com/peter/archives/2008/09/acyclovir_one_r.html

If you comment here, please cut & paste your comment below my blog posting as well.

Thanks for reading!

Interesting. I tested positive for both HSV1 and HSV2 earlier this year. I have never had any symptoms of either yet. I just wanted to have a complete STD panel and never had been tested for either. I am not on ARV at this point.
Would it still be a good idea for me to be on acyclovir for prophylaxis ?

Offline Peter Staley

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Re: Acyclovir -- One Reason Why I'm Still Alive?
« Reply #11 on: September 20, 2008, 10:46:52 AM »
Peter,

Interesting. I tested positive for both HSV1 and HSV2 earlier this year. I have never had any symptoms of either yet. I just wanted to have a complete STD panel and never had been tested for either. I am not on ARV at this point.
Would it still be a good idea for me to be on acyclovir for prophylaxis ?


I'd say no.  If you start getting outbreaks, then yes, but until then, I wouldn't bother.  While acyclovir's antiviral effects are interesting, they aren't confirmed yet by other scientists.  Also, if it DOES act like an NRTI, then you'd be on monotherapy, which is a no-no.

 


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