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Author Topic: Simplifying regimen in general -- specifically Prezista daily / Norvir tablet  (Read 1546 times)

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Offline Assurbanipal

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  • Posts: 2,173
  • Taking a forums break, still see PM's


Called the ID doc earlier this week (seems like we are on the phone a lot recently) and asked if we could look at simplifying my current regimen. 

I'm on twice a day Prezista / Norvir (plus once a day Epzicom) and there has been tow recent developments that would make things a lot simpler:

- First, the new heat/stable Norvir tablet is out.  Medco (my drug plan) says it is available for order now.  It costs the same amount as the capsules and I need to renew that prescription soon anyway.  The doc wanted to know how big the tablet was and what it looked like, but otherwise seemed amenable.  I think she had forgotten how big the Norvir capsules are until I showed her one last month. Does anyone have a source for the physical dimensions of the tablet?

 - Second, the study at CROI that showed once a day Prezista / Norvir was usually as safe or maybe even better than twice a day.  It has only 2/3rds the daily Prezista and half the Norvir.  The AIDSMEDS writeup is here http://www.aidsmeds.com/articles/HIV_prezista_dosing_2446_18025.shtml.  She is going to look at the paper (I'm not sure there is a paper yet?)

She seemed a bit caught off guard.  Are other folks talking to their docs about moving to once a day Prezista/Norvir or about moving to the Norvir tablets instead of the capsules?

More generally, when you have simplified a regimen in the past, did you initiate the discussion or did the doctor?

Thanks
Assurbanipal

** Note to the mods: couldn't decide whether to post this here because of the general questions, or in treatment and side effects.  Feel free to move it to where it fits best.
5/06 VL 1M+, CD4 22, 5% , pneumonia, thrush -- O2 support 2 months, 6/06 +Kaletra/Truvada
9/06 VL 3959 CD4 297 13.5% 12/06 VL <400 CD4 350 15.2% +Pravachol
2007 VL<400, 70, 50 CD4 408-729 16.0% -19.7%
2008 VL UD CD4 468 - 538 16.7% - 24.6% Osteoporosis 11/08 doubled Pravachol, +Calcium/D
02/09 VL 100 CD4 616 23.7% 03/09 VL 130 5/09 VL 100 CD4 540 28.4% +Actonel (osteoporosis) 7/09 VL 130
8/09  new regimen Isentress/Epzicom 9/09 VL UD CD4 621 32.7% 11/09 VL UD CD4 607 26.4% swap Isentress for Prezista/Norvir 12/09 (liver and muscle issues) VL 50
2010 VL UD CD4 573-680 26.1% - 30.9% 12/10 VL 20
2011 VL UD-20 CD4 568-673 24.7%-30.6%
2012 VL UD swap Prezista/Norvir for Reyataz drop statin CD4 768-828 26.7%-30.7%

Offline Okealyshire

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  • Posts: 139
In an earlier post I described my simplified regimen change. I had been taking Truvada + Reyataz + Norvir since November 2007. I dropped the Truvada and replaced it with Epzicom; I increased the Reyataz from 300 mg to 400 mg; and I eliminated the Norvir. So far this combo is working very well for me.

In your case, since you're already on Epzicom, talk to your doc about exchanging Prezista + Norvir for unboosted Reyataz.

Offline Assurbanipal

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  • Taking a forums break, still see PM's
In your case, since you're already on Epzicom, talk to your doc about exchanging Prezista + Norvir for unboosted Reyataz.

Back when I switched to Isentress/Epzicom we talked about Reyataz, but she was not comfortable about the strength of Reyataz given that I'd technically failed on Kaletra (although at a very low viral load).  She really wanted a boosted PI

So I'm willing to stick with Prezista for a while -- I just want to make it a once a day regimen.
5/06 VL 1M+, CD4 22, 5% , pneumonia, thrush -- O2 support 2 months, 6/06 +Kaletra/Truvada
9/06 VL 3959 CD4 297 13.5% 12/06 VL <400 CD4 350 15.2% +Pravachol
2007 VL<400, 70, 50 CD4 408-729 16.0% -19.7%
2008 VL UD CD4 468 - 538 16.7% - 24.6% Osteoporosis 11/08 doubled Pravachol, +Calcium/D
02/09 VL 100 CD4 616 23.7% 03/09 VL 130 5/09 VL 100 CD4 540 28.4% +Actonel (osteoporosis) 7/09 VL 130
8/09  new regimen Isentress/Epzicom 9/09 VL UD CD4 621 32.7% 11/09 VL UD CD4 607 26.4% swap Isentress for Prezista/Norvir 12/09 (liver and muscle issues) VL 50
2010 VL UD CD4 573-680 26.1% - 30.9% 12/10 VL 20
2011 VL UD-20 CD4 568-673 24.7%-30.6%
2012 VL UD swap Prezista/Norvir for Reyataz drop statin CD4 768-828 26.7%-30.7%

 


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