Quantcast

Subscribe to:
POZ magazine
E-newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join
Username:
Password:
Welcome, Guest. Please login or register.
August 28, 2014, 08:08:41 AM

Login with username, password and session length


Members
Stats
  • Total Posts: 636404
  • Total Topics: 48299
  • Online Today: 165
  • Online Ever: 585
  • (January 07, 2014, 02:31:47 PM)
Users Online

Welcome


Welcome to the POZ/AIDSmeds Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ/AIDSmeds community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Prezista/Norvir, Isentress and Intelence-anyone else on this combo?  (Read 2890 times)

0 Members and 1 Guest are viewing this topic.

Offline todd123

  • Member
  • Posts: 67
  • "You don't ask, you don't know."
I just started this combo 2 weeks ago.  I should state that I am a treatment "naive" patient (meaning I've not been on meds_)
The reason being that against all advice, I waited to get tested until something showed up.  In this case it was a case of Molloscum
Contagiosum.  My numbers are really bad CD4 16 viral load over a million; thus the aggressive treatment by doctor after consulting with
two other ID specialists.
I'm very scared about the damage I've already done to my system through neglect, but I'm going to have a different approach now
certainly.

Because it's a relatively new combo, I would be interested to hear people's experiences.

Thanks so much everyone

Scott
Tested HIV+ July 28, 2008
CD4 16 VL over 400,000
Started Prezista/Norvir, Isentress and Intelence; Mepron
8/08   CD4 64    2%      VL 1500
9/08   CD4 135  6%      VL 371
11/08 CD4 104   9%     VL 156
12/08 CD4 161   9%     VL 400
01/09 CD4 109   7%     VL 351
02/09 CD4 218   8%     VL   98
03/09 CD4   80   5%     VL   98 at least that's the same
04/09 CD4 150   7%      VL 100
05/09 CD4 232   8%      VL   90

Offline sanitex

  • Member
  • Posts: 385
Re: Prezista/Norvir, Isentress and Intelence-anyone else on this combo?
« Reply #1 on: August 11, 2008, 02:35:40 AM »
Hi Todd.
               My dear you're wellcome to the forum,anyway i do not know much about this combo and hiv its self but i'll only give you an encouragement ,likewise mine when i first diagonised my cd4 was 20 and vl was 1000000 but i still thank God for his mercy over his people. i'm on meds sustiva,lamuvidine,tenofovir,for seven months so i think your cd4 will still come back at the nomal range ok.take care and remain bless.
 

27/12/07 cd4 20 vl 1000000
10/4/8 cd4 96 vl 63
1/7/08 cd4 186 vl undetectable
but still hoping for new number nest test.                   
27/12/07 cd4 20 vl 1million
10/4 /08 cd4 86 vl 63
1/7/08  cd4 186 vl undetectable
16/10/08 cd4 196 vl undet
23/1/09 cd4 248 vl un
10/9/11 cd4 418 vl <40 %22
13/12/11 cd4 410 vl undet 23%
24/2/12 cd4 545 vl undet 26%
on 22/2/12 change truvada to Recovir-EM
due to no stock on Truvada.
10/9/11 cd4 418 vl <40 %22
7/7/12 cd4 359 vl <40 22%
23/8/12 cd4 400 vl <40 23%,
testosterone test 7.5 ng/ml and
thyroid (TSH)1.32 ulu/ml creatinine.eGFR blck 1.5 all fasting test morning.
13/12/2012 cd4 523 24% vl <40
18/3/2013 cd4  513  23% vl <40
regimen ATRIPLA
03/8/2013 cd4 429 22% vl <40
13/11/2013 cd4 455 23% vl <40
Anti-HBs test (quantitative ) Anti-HBs positive
Titer 16.95 mlu/ml <10.00
22/3/14 cd4 396 vl <40 % 24
24/7/14 change to Teevir

Offline blondbeauty

  • Member
  • Posts: 1,784
Re: Prezista/Norvir, Isentress and Intelence-anyone else on this combo?
« Reply #2 on: August 11, 2008, 02:36:49 AM »
My friend Felix is in a very similar situation. His lower CD4 count was 4 buit he started treatment with 19 CD4. His first treatment was sustiva + truvada but it did not work so they added Videx. This one didnīt also. So he started Prezista + Norvir + Isentress + Maraviroc. It aslo failed. Now he is on Prezista + Norvir + Intelence + Viread + Combivir.
Tomorrow he will have teh results at another clinic. Lets see how it goes... I will keep you updated.
The only member in these forums approved by WINBA: World International Nail and Beauty Association.
Epstein Barr +; CMV +; Toxoplasmosis +; HIV-1 +.
Counts when starting treatment:
V.L.:80.200 copies. CD4: 25%=503
Started Sustiva-Truvada 14/August/2006
Last V.L.count (Oct 2013): Undetectable
Last CD4 count (OCT 2013): 52%= 933

Online Miss Philicia

  • Member
  • Posts: 24,005
  • celebrity poster, faker & poser
Re: Prezista/Norvir, Isentress and Intelence-anyone else on this combo?
« Reply #3 on: August 11, 2008, 02:41:27 AM »
I'm on all of those meds, except Intelence.  Not sure what you'd be interested in hearing from me, as I didn't have your numbers when I began, and have been on HIV treatment for 15 years.

Otherwise I've had little to no side effects from this regimen.  Best of luck.
"Iíve slept with enough men to know that Iím not gay"

Offline Doughboyjbird

  • Member
  • Posts: 11
  • Just Me...
Re: Prezista/Norvir, Isentress and Intelence-anyone else on this combo?
« Reply #4 on: August 11, 2008, 10:20:15 AM »
Good morning,

I am on Prezista/Norvir, Isentress and Truvade.  I have been on these for 2 years.  I did not have any side affects and the meds worked good for me.  I have been resistant to a lot of combos, but when they put me on Prezista, My T cells were 160, viral load was staying around 300,000.  In just 4 weeks, my viral load was undetectable.  That was the first time in the 20 years of being positive.

Now, 2 years later, we have learned that the Prezista and Norvir combo, super charges the immune system.  I take (Toke) Advair inhaler for my asthma .  The meds supercharged the steroid and made me have all the systems of Cushings.  Weight gain, swelling, stretch marks, thin skin etc.  Now that all my doctors know this, you really have to be careful of other meds and how they will react to the HIV drugs.  Please read up and be educated.

Don't get me wrong, the meds we are on are in my opinion, some of the best!

Jay

Offline todd123

  • Member
  • Posts: 67
  • "You don't ask, you don't know."
Re: Prezista/Norvir, Isentress and Intelence-anyone else on this combo?
« Reply #5 on: August 11, 2008, 12:48:01 PM »
I cannot thank all of you enough for your shared experience.  I have to go for labs next week, to see how it's working.
Once I'm up to 200 CD4, the doc will be taking me off one of those drugs.  I forget which one at the moment.

I'll let you all know. 

best,

Scott
Tested HIV+ July 28, 2008
CD4 16 VL over 400,000
Started Prezista/Norvir, Isentress and Intelence; Mepron
8/08   CD4 64    2%      VL 1500
9/08   CD4 135  6%      VL 371
11/08 CD4 104   9%     VL 156
12/08 CD4 161   9%     VL 400
01/09 CD4 109   7%     VL 351
02/09 CD4 218   8%     VL   98
03/09 CD4   80   5%     VL   98 at least that's the same
04/09 CD4 150   7%      VL 100
05/09 CD4 232   8%      VL   90

Offline Peter Staley

  • Member
  • Posts: 1,337
  • Founder & Advisory Editor, AIDSmeds.com
    • AIDSmeds.com
Re: Prezista/Norvir, Isentress and Intelence-anyone else on this combo?
« Reply #6 on: August 12, 2008, 08:09:39 AM »
Now, 2 years later, we have learned that the Prezista and Norvir combo, super charges the immune system. 

Jay

Hey, Jay -- can you site a reference for this?  I'm wondering if you're talking about Immune Reconstitution Syndrome, which can happen with HAART drugs in general (not specific to your combo).  Here's a good description of this syndrome:

http://aids.about.com/od/otherconditions/a/immunerecon.htm

Peter


Offline Doughboyjbird

  • Member
  • Posts: 11
  • Just Me...
Re: Prezista/Norvir, Isentress and Intelence-anyone else on this combo?
« Reply #7 on: August 12, 2008, 09:40:45 AM »
http://www.netdoctor.co.uk/medicines/100005131.html

This is a link that explains how the drugs work.  The combination can cause many different side affects depending on the other drugs you use.  All my doctors first said that I was taking steroids.  The only steroid I had was Advair for asthma.  All of them said there was no way that little could do what it was doing.  I gave them copies of this site and a few other.  The drugs were increasing the amount of steroid in my blood causing Cushing systems.  Now that I quit taking Advair, my swelling is going down with weight!!! and I am starting to get better.

I am trying to find the website the explains that the combination will lower the viral load and give the immune system time to rebuild.  What I have had happen is the the immune system gets stronger and starts fighting little infections or viruses.  I recently had a wart removed from my inside lip.  I have never had warts!  I was told the the immune system to working over time on whatever it could find.  In this case, the Dermatologist said it could be the HPV virus.

Don't get me wrong, I am Happy to be undetectable and T-Cells on the rise from 375.  My experience with the cocktails side affects and be no probelm.  I get the long term side affect.  Norvir, may have caused my Heart attack in 2000.  Protease Inhibitors, cause avascular necrosis in both hips.  In 2003, I had both hips replaced.  No optimistic infections ever.  Just long term usage..

Jay

Offline Peter Staley

  • Member
  • Posts: 1,337
  • Founder & Advisory Editor, AIDSmeds.com
    • AIDSmeds.com
Re: Prezista/Norvir, Isentress and Intelence-anyone else on this combo?
« Reply #8 on: August 12, 2008, 10:51:39 AM »
Ah, thanks for the clarification.  You had a drug/drug interaction, which we mention on the AIDSmeds page for Prezista as well:

"Prezista/Norvir can increase blood levels of Advair, Flovent, or Flonase (fluticasone), the inhalable medications that are used to treat allergies and asthma. In turn, these drugs may decrease blood levels of Prezista/Norvir. Alternatives to these drugs should be considered, especially for long-term use."
http://www.aidsmeds.com/archive/Prezista_1562.shtml

But I am still confused by your statement saying "that the Prezista and Norvir combo, super charges the immune system."  It doesn't.  It's a boosted protease inhibitor, and acts like all the others.  When used in a 3-drug combo, it should lower VL, and that leads to a recovery of CD4 cells.

Peter

Online Miss Philicia

  • Member
  • Posts: 24,005
  • celebrity poster, faker & poser
Re: Prezista/Norvir, Isentress and Intelence-anyone else on this combo?
« Reply #9 on: August 12, 2008, 11:41:12 AM »
Personally I had a remarkable immune system response when I went on Prezista/Norvir, but it was combined with Fuzeon at the same time.  My doctor had kept me from going on Fuzeon a year earlier, though I really needed it in terms of my viral load, because he was seeing data that the synergy of the Prezista/Fuzeon combo was getting a good response.  My cd4s went from ~500 to ~900 within two months and maintained that boost consistently for a year.  Upon replacing Fuzeon with Isentress they increased to ~1300.

For me at least, these new med combos are remarkable -- very very strong, and with little to no side effects (I'm not counting the fuss with Fuzeon as a side effect as there's no way to get around the delivery of it.  Once it's in your body there is no side effect for the vast majority of patients.)

But yes, I'd agree with Peter that just the Prezista/Norvir statement is most likely not an accurate claim at all.
"Iíve slept with enough men to know that Iím not gay"

Offline Doughboyjbird

  • Member
  • Posts: 11
  • Just Me...
Re: Prezista/Norvir, Isentress and Intelence-anyone else on this combo?
« Reply #10 on: August 12, 2008, 12:46:49 PM »
Please forgive me everyone.  I did not mean to make a "factual" statement.  Just that the meds hold back the virus back so well, your immune systems seems to be catching up on lost time.

I am not always very good at these forums.  Maybe I should just stick to reading them!

Regretfully,


Offline Peter Staley

  • Member
  • Posts: 1,337
  • Founder & Advisory Editor, AIDSmeds.com
    • AIDSmeds.com
Re: Prezista/Norvir, Isentress and Intelence-anyone else on this combo?
« Reply #11 on: August 12, 2008, 01:29:37 PM »
Jay -- don't you dare stop posting here!  I've really enjoyed your input thus far.  You'll often find me in here trying to clarify various statements about the meds, just so other readers don't end up misreading something.

Cheers,

Peter

Offline todd123

  • Member
  • Posts: 67
  • "You don't ask, you don't know."
Re: Prezista/Norvir, Isentress and Intelence-anyone else on this combo?
« Reply #12 on: August 12, 2008, 09:11:48 PM »
Peter,

I so appreciate that you take the time to clarify these things for us.  Believe me, I'm overwhelmed right now,
and it's so good to hear ALL these voices of reason.  As soon as I know more, maybe I'll have some informational
posts, other than help me, help me.   ;)

Scott
Tested HIV+ July 28, 2008
CD4 16 VL over 400,000
Started Prezista/Norvir, Isentress and Intelence; Mepron
8/08   CD4 64    2%      VL 1500
9/08   CD4 135  6%      VL 371
11/08 CD4 104   9%     VL 156
12/08 CD4 161   9%     VL 400
01/09 CD4 109   7%     VL 351
02/09 CD4 218   8%     VL   98
03/09 CD4   80   5%     VL   98 at least that's the same
04/09 CD4 150   7%      VL 100
05/09 CD4 232   8%      VL   90

 


Terms of Membership for these forums
 

© 2014 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.