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Author Topic: MRKAd5 has NOT killed T-cell-based HIV vaccines concept!  (Read 1356 times)

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Offline leit

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  • Posts: 236
MRKAd5 has NOT killed T-cell-based HIV vaccines concept!
« on: August 05, 2008, 09:40:51 AM »
«The problem with MRKAd5, he [David Watkins] argued, was not that it tried to ignite a cellular response, but that it did so feebly. Julie McElrath confirmed that assessment in her presentation, noting low overall CD4 and CD8 response rates in vaccinated people [3]. And CD4 or CD8 cells inconsistently secreted the cytokines (cell-to-cell messengers) interferon-gamma, interleukin-2, and tumor-necrosis factor-alpha in vaccinated participants. Only one third of vaccinated people had measurable levels of all three cytokines.

In a published essay, the University of Oxford's Tomas Hanke propounded the same apologia Watkins advanced, writing that MRKAd5 "did not reach the limits of vaccine T-cell induction and its design can be improved both from the point of the HIV-1-derived immunogens and their delivery" [1]. So this vaccine's demise, Hanke concluded, "cannot be a reason for dismissal of the whole T-cell vaccine concept."»

« Last Edit: August 05, 2008, 09:50:12 AM by leit »

Offline Matty the Damned

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  • Posts: 12,160
Re: MRKAd5 has NOT killed T-cell-based HIV vaccines concept!
« Reply #1 on: August 05, 2008, 09:48:56 AM »
Hey Leit,

It's great that you're keeping on top these developments. Why don't explain to the rest of us what this research means in your own words.

I don't mean by carbon copying some abstract or quoting verbatim an article that someone else has written.

Interpret it for us doll. Inquiring minds want to know and all that.


Offline leit

  • Member
  • Posts: 236
Re: MRKAd5 has NOT killed T-cell-based HIV vaccines concept!
« Reply #2 on: August 05, 2008, 10:01:52 AM »
Why don't explain to the rest of us what this research means in your own words.

Can't you read the subject and what I have highlighted with bold?

Interpret it for us doll.


Offline Matty the Damned

  • Member
  • Posts: 12,160
Re: MRKAd5 has NOT killed T-cell-based HIV vaccines concept!
« Reply #3 on: August 05, 2008, 10:03:45 AM »
So you don't know what you're talking about.


/edited for a typo/
« Last Edit: August 05, 2008, 10:11:41 AM by matty.the.damned »


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