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Author Topic: When is melted too melted?  (Read 2985 times)

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Offline aztecan

  • Member
  • Posts: 5,399
  • 29 years positive, 57 years a pain in the butt
When is melted too melted?
« on: August 02, 2008, 01:42:29 AM »
I recently had to travel to another city by car. I had put my suitcase, in which my meds were packed, in the trunk of the car.

No problem on the way out, but on the journey home, the temperatures were in the triple digits.

My Norvir melted. Well actually, partially melted. They capsules were deformed and were sort of stuck in the pill box.

So, I put them in the fridge. Once they were cool, they came out of the pill box without a problem and hadn't leaked.

I continued to take them, but was wondering how melted Norvir has to get before it is not useable.

Anyone have any idea how melted is too melted?

HUGS,

Mark
"May your life preach more loudly than your lips."
~ William Ellery Channing (Unitarian Minister)

Offline Matty the Damned

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  • Posts: 12,228
  • Ninja Please
Re: When is melted too melted?
« Reply #1 on: August 02, 2008, 02:05:37 AM »
I'm thinking they're probably OK Mother, but if you can have them replaced with no enormous fuss, it might be worth doing.

MtD

Offline J.R.E.

  • Member
  • Posts: 7,215
  • Joined Dec-2003 Living positive, since 1985.
Re: When is melted too melted?
« Reply #2 on: August 02, 2008, 04:36:18 AM »

HHmmmmmm,


I don't know Mark. Maybe you should call the pharmacy, and see what they say. But if they were melted...Ouch !


Ray
Current Meds ; Viramune, Epzicom, 40mg of simvastatin, 12.5mg of Hydrochlorothiazide.
Metoprolol tartrate 25mg



http://forums.poz.com/index.php?topic=40802.0

http://forums.poz.com/index.php?topic=45159.0

http://forums.poz.com/index.php?topic=39722.msg495621;topicseen#msg495621

http://forums.poz.com/index.php?topic=46806.0

http://forums.poz.com/index.php?topic=39414.msg491701#msg491701


 In October of 2003, My t-cell count was 16, Viral load was over 500,000, Percentage at that time was 5%. I started my first  HAART regimen  on October 24th,03.

 As of 8/2514,  t-cells are at 402, Viral load <40

 Current % is at 11%

  
 62 years young.

Offline newt

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  • the one and original newt
Re: When is melted too melted?
« Reply #3 on: August 02, 2008, 05:59:23 AM »
Too melted

- matt
"The object is to be a well patient, not a good patient"

Offline Alain

  • Member
  • Posts: 680
  • I am.
Re: When is melted too melted?
« Reply #4 on: August 02, 2008, 06:20:45 AM »
Aren't they supposed to be refrigerated at all time?

When I travel, I used a small cooler bag with and ice pack.

I am off that one now, but I still have some left and there is a sticker on the bottle from the pharmacy that clearly state do not freeze , but keep in refrigerator.

Alain.

Offline leit

  • Member
  • Posts: 236
Re: When is melted too melted?
« Reply #5 on: August 02, 2008, 06:24:03 AM »
In any case, good news for you (and many others), AZTECAN!

http://forums.poz.com/index.php?topic=22327.msg284464#msg284464


Offline Peter Staley

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  • Posts: 1,337
  • Founder & Advisory Editor, AIDSmeds.com
    • AIDSmeds.com
Re: When is melted too melted?
« Reply #6 on: August 02, 2008, 08:48:21 AM »
Norvir doesn't need constant refrigeration.  Check out this thread on Norvir Storage:

http://forums.poz.com/index.php?topic=21127.0

Peter

Offline newt

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  • the one and original newt
Re: When is melted too melted?
« Reply #7 on: August 02, 2008, 10:13:55 AM »
Norvir degrades under thermal, alkaline and oxidative conditions (air/moisture). Critically, the active ingedient degrades relatively fast at temperatures over 35 deg C (95 deg F).  This is in dry air, no direct sunlight. Humidity/direct sunlight may well increase degree of degredationt.

I would not use clumped capsules.

- matt
"The object is to be a well patient, not a good patient"

Offline Miss Philicia

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  • celebrity poster, faker & poser
Re: When is melted too melted?
« Reply #8 on: August 02, 2008, 02:54:21 PM »
Mark, I have lots of excess Norvir (2 months worth) if you'd like me to bring it to Mexico City, but I realize that may be too late.
"Iíve slept with enough men to know that Iím not gay"

Offline Dachshund

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  • Posts: 5,969
Re: When is melted too melted?
« Reply #9 on: August 02, 2008, 03:22:28 PM »
I was going to say the same thing. I have a ton of extra Norvir that I could overnight to you if you need it.

Hal

Offline thunter34

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  • Posts: 7,314
  • His name is Carl.
Re: When is melted too melted?
« Reply #10 on: August 02, 2008, 04:09:41 PM »
Norvir degrades under thermal, alkaline and oxidative conditions (air/moisture). Critically, the active ingedient degrades relatively fast at temperatures over 35 deg C (95 deg F).  This is in dry air, no direct sunlight. Humidity/direct sunlight may well increase degree of degredationt.

I would not use clumped capsules.

- matt


Ah....well, then.  Let's just hope I got by with it.  Just finished an entire month's supply that was that way.  They semi-melted into a giant clump in the bottle that I carefully plucked individual pills off of once I was able to get some of them loose enough to come out of the bottle.  Guess we'll find out at my next labs, eh?
AIDS isn't for sissies.

Offline aztecan

  • Member
  • Posts: 5,399
  • 29 years positive, 57 years a pain in the butt
Re: When is melted too melted?
« Reply #11 on: August 03, 2008, 10:53:28 PM »
Thanks Philly and Doxie for the offer, but I only melted about four days worth of meds. They were the ones I had put in the pill box.
The others were in the fridge at home, safe and unmelted.

The bottles do say they can be stored outside of refrigeration for a month, but only at temperatures of 75 degrees F or less.  I don't know what that is centigrade.

The problem is, even my house doesn't stay below 75 degrees. Right now, with the air conditioner going, it is 82.

Evaporative cooling isn't a precise science, but 82 is much more comfortable than 103, which it is outside.

So I keep my meds and my pill box in the frig.

From now on, when I travel, I will keep them with me in the car. not in the trunk.

Lesson learned.

In any case, good news for you (and many others), AZTECAN!

http://forums.poz.com/index.php?topic=22327.msg284464#msg28446

That is interesting news. I hope they do come out with a pill form that doesn't need refrigeration. It would be just so much easier.

HUGS,

Mark
« Last Edit: August 03, 2008, 11:13:00 PM by aztecan »
"May your life preach more loudly than your lips."
~ William Ellery Channing (Unitarian Minister)

Offline AndyArrow

  • Member
  • Posts: 1,196
Re: When is melted too melted?
« Reply #12 on: August 17, 2008, 04:40:53 AM »
If you have to do a lot of traveling without access to refrigeration or good a/c you might want to consider getting a prescription of liquid Norvir for those times.

It tastes pretty nasty (like most meds) but it doesn't need refrigeration and last about 10 months.

You can also try mixing it with Ensure or chocolate milk to lessen the taste.

AA

typo
« Last Edit: August 17, 2008, 04:42:52 AM by AndyArrow »
It is not the arrival that matters.  It is the journey along the way. -- Michel Montaigne

 


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