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Author Topic: Could this be the holy grail ?  (Read 160714 times)

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Offline steppenwolf

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Re: Could this be the holy grail ?
« Reply #400 on: September 01, 2009, 01:42:20 PM »
Peregrine Pharmaceuticals to Present at the Rodman & Renshaw 11th Annual Healthcare Conference

- Presentation to Be Webcast Live On Company's Website -

TUSTIN, Calif., Sept 01, 2009 /PRNewswire-FirstCall via COMTEX News Network/ -- Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM) today announced that senior management will present at the Rodman & Renshaw 11th Annual Healthcare Conference on Thursday, September 10, 2009 at 10:25 am EDT. The conference will be held at the New York Palace Hotel in New York City.

A live webcast of the company's presentation will be available at the Investors section of Peregrine's website at www.peregrineinc.com. A replay will be available on the Peregrine website and archived for 90 days.

For more information about this conference, please visit: http://www.rodmanandrenshaw.com/conferences?id=30


Offline veritas

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Re: Could this be the holy grail ?
« Reply #402 on: September 03, 2009, 07:18:17 PM »
Carlos,

Great find!  

What stood out for me upon reading your links was the following:

"One, codenamed PG9, neutralised 127 of 162 HIV strains and the other, codenamed PG16, neutralised 119."

This shows what collaboration can do. The greater the number of antibodies that can be incorporated into a vaccine ,the stronger the immune response. Since they obtained these antibodies from someone who is controlling the virus, this bodes well for it's therapeutic value.

Thanks for posting!

"The work goes on."



v
« Last Edit: September 03, 2009, 07:24:11 PM by veritas »

Offline veritas

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Re: Could this be the holy grail ?
« Reply #403 on: September 04, 2009, 05:25:50 AM »

Carlos,

Here is a an image of the antibodies and the virus:


http://www.scripps.edu/news/press/images/20090831_IAVI/HIV-1_trimer.jpg


Caption: Modeling the PG9 and PG16 epitopes onto the HIV-1 trimer. The above model is adapted from a recent cryo-electron tomographic structure of the HIV-1 trimer. The crystal structure of the gp120 core (orange) has been fitted into the density map. The V1/V2 and V3 loops, which are not resolved in the crystal structure, are represented as green and yellow ovals, respectively. The approximate locations of gp41 and the viral membrane (not resolved in the structure) are shown in blue. The red structure located above the trimer is a human IgG molecule representative of PG9 and PG16. The PG9 and PG16 epitopes are believed to involve residues in the V1/V2 and V3 loops of gp120.

v


Offline veritas

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Re: Could this be the holy grail ?
« Reply #404 on: September 04, 2009, 05:45:30 AM »

Steven King, president of pphm, answers question pertaining to anti-viral program on yesterday's conference call:

My question in regard to the company is a very exciting antiviral program and the scarcity of public information about them; everyone understands that these programs have been paid for with other people’s money like Duke and NIH, and they should be the first to get the spotlight, but after the Nature Medicine article was published, will you be able to talk more freely about things, non-DPRA, things like aerosol delivery, HIV microbicides, possible swine flu applications, etc., or will the public secrecy have to remain over those antiviral programs?

Steven W. King

Yes, it’s a good question, and certainly our goal is to see a number of publications, presentation, and such coming from this research to really just to let the public know how the programs are proceeding and what the results are looking at as they move forward, and also that things shine a light on what our future plans are for the program. So, I think we’ll have opportunities actually to not just talk about it or publish the work we’re doing with our collaborators like Duke and the other institutions involved in researching our antiviral applications of our PS technology, but also even some opportunities present data from the DPRA contract work and shine some light on how those studies are proceeding, and I believe that all of our collaborators are equally interested in seeing that information get out there in really the right formats and in the right settings. So, all those preparations are in work and I think you’ll see more coming out of the programs from a public standpoint over the coming months, and certainly we’re excited to get that information out there because we’re very happy with the way all of these studies are progressing and what we’re seeing in the pre-clinical study.

v

Offline veritas

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Re: Could this be the holy grail ?
« Reply #405 on: September 04, 2009, 08:26:02 AM »

Another follow-up to PG9 and PG16 antibodies:

http://www.bloomberg.com/apps/news?pid=20601124&sid=akGVjigUJynU

The sentence in the above link that I found intriguing was the following:


"The antibodies themselves can’t simply be put in a vaccine to immunize people against HIV, said Wayne Koff, senior vice president of research and development at the Vaccine Initiative in New York. While such an effort could have a short-term benefit, a successful vaccine will teach people’s immune systems to produce their own powerful antibodies"

I wonder what type of delivery system they will need?  ( anti-ps anyone!).

It's Happening!

v

Offline veritas

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Re: Could this be the holy grail ?
« Reply #406 on: September 04, 2009, 08:47:13 AM »
In the above link, click on GRAPHIC at the top of the story. The graphic shows how difficult it would be for those antibodies to find the appropriate target. Also in that graphic, see how the virus shields itself from the immune system. For anyone following this thread, they know that those immune shielding appendicies are flipped ps. Bavi shines the light, allowing the immune system to do it's job.

"The work goes on"!

v
« Last Edit: September 04, 2009, 08:48:46 AM by veritas »

Offline Inchlingblue

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Re: Could this be the holy grail ?
« Reply #407 on: September 04, 2009, 11:44:44 AM »
The sentence in the above link that I found intriguing was the following:


"The antibodies themselves can’t simply be put in a vaccine to immunize people against HIV, said Wayne Koff, senior vice president of research and development at the Vaccine Initiative in New York. While such an effort could have a short-term benefit, a successful vaccine will teach people’s immune systems to produce their own powerful antibodies"
 

Another way would be to directly inject into muscle the genes that are responsible for the antibodies, producing a potentially endless supply and bypassing the immune system altogether. One of the articles mentioned that they isolated these genes.

For those who might be confused: PG9 and PG16 are not anti-ps antibodies.

I started a new thread for this in order to avoid confusion.
« Last Edit: September 04, 2009, 11:53:26 AM by Inchlingblue »

Offline veritas

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Re: Could this be the holy grail ?
« Reply #408 on: September 04, 2009, 02:20:47 PM »


Inch,

Your absolutely correct that the PG9 and PG16 antibodies are not anti-ps antibodies. Neither are 4E10,2F5 or 2g12 antibodies. These are the killer antibodies to the virus. Anti-ps antibodies (3g4, IS4,etc.) are the anti-ps antibodies that attach to the flipped ps on the virus and infected cells. Anti-ps antibodies do not kill the virus. They eliminate the viral shield that the virus uses to evade the immune system They "shine the light"   on the virus so the immune system can do it's job. Think of the PG9 and PG16 as missiles that need to be guided to their target. Anti-ps is the guidance system allowing them to do their job. Yes, these super killer antibodies were found in an elite controller, that was keeping the virus at bey (in effect a functional cure), however that controller was and is HIV+.

Now if you bring up the graphic posted in the Bloomberg link above, you can see the gp120 target that these antibodies go after. That target is partially hidden thus some of the virus will always escape. That's why this elite controller was not able to eradicate the virus from his system. The antibodies find enough of them to prevent progression to AIDS in the blood but they cannot reach the latent cells since their target is on the virus itself. Thiese antibodies are very powerful and do their job efficiently, however, eradication can not occur without elimination of all infected cells. This find just might be the necessary immune response to that end along with anti-ps antibodies to guide them.

This find makes me more hopeful than ever that their will be a cure and a vaccine for this disease in our lifetime.

v

ps: By the way, I'd certainly take a functional cure but I believe that better things are afoot. It's Happening!

Offline veritas

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Re: Could this be the holy grail ?
« Reply #409 on: September 04, 2009, 03:36:25 PM »

Hot off the press --- researchers believe they have found a way  to produce broadly neutralizing anti-bodies:

http://www.sciencedaily.com/releases/2009/09/090901143319.htm

"It has been believed that it might be difficult to induce such antibodies experimentally, and historically, this has been considered a potential roadblock to creation of an effective HIV vaccine. This study demonstrates that such antibodies might be induced with immuno-stimulating liposomes"

The study:

http://journals.lww.com/aidsonline/Abstract/publishahead/Neutralizing_antibodies_induced_by_liposomal_HIV_1.99750.aspx

v

Offline veritas

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Re: Could this be the holy grail ?
« Reply #410 on: September 04, 2009, 03:54:38 PM »


The previous post showed how using liposomes  can allow the immune system to develop anti-HIV antibodies. But what is a liposome?:

http://encyclopedia2.thefreedictionary.com/Liposomes

Liposomes have numerous uses as biochemical and biophysical tools: (1) as vehicles for the delivery of both water- and of oil-soluble materials to the cell; (2) as immunological adjuvants; (3) as substrates for the study of membrane properties such as rotational or translational diffusion in the plane of the membrane; and (4) as intermediates in the construction of bilayers large enough for the study of electrical properties of membranes

v

Offline Inchlingblue

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Re: Could this be the holy grail ?
« Reply #411 on: September 04, 2009, 05:46:31 PM »
v, your thread is getting confusing (to me at least)...isn't this what was being discussed in a recent thread entitled "Researchers Induce HIV-neutralizing Antibodies against envelope protein+ lipids"?

http://forums.poz.com/index.php?topic=28778.0

Offline veritas

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Re: Could this be the holy grail ?
« Reply #412 on: September 05, 2009, 04:40:41 AM »

The relevant paragraph in the study in the following link:

http://journals.lww.com/aidsonline/Abstract/publishahead/Neutralizing_antibodies_induced_by_liposomal_HIV_1.99750.aspx

is as follows:

The discovery of the novel lipid-binding properties of 2F5 and 4E10 has generated interest in the possibility that the binding of the antibodies to lipids themselves might participate as a part of the neutralizing mechanism of certain types of antibodies [17,22]. By utilizing liposomal methodology for inducing antibodies to lipids [23,24], a murine antiphosphatidylinositol-4-phosphate (anti-PIP) mAb (WR304) was produced that exhibited neutraliz­ation of infection by two primary HIV-1 isolates in a peripheral blood mononuclear cell (PBMC) assay but lacked any activity in the corresponding pseudovirus assay utilizing TZM-bl cells [25]. These observations were subsequently confirmed with several human IgG mAbs [PGN632, P1, IS4-, and CL1] that exhibited beta2­glycoprotein I-independent binding to pure phospholi­pids and that also neutralized in the PBMC assay but not in the TZM-bl pseudovirus assay [26]. The ability of antibodies to bind to PIP to neutralize in the PBMC assay is particularly interesting because phosphoinositides, including PIP, are important constituents of the HIV-1 lipid bilayer and phosphoinositides are enriched in the HIV-1 envelope lipid bilayer when compared with the plasma membranes of target and host cells [27].
In the present work, by using a widely employed, clinically acceptable, well tolerated, and potent antigen– adjuvant formulation [28–32], we have produced multi-specific neutralizing mAbs that simultaneously bind to lipids, including PIP, and also to peptides that either encompassed the complete core MPER-binding speci­ficity of 2F5 or part of the core-binding specificity of 4E10. The ease of production of these mAbs demon­strates that multispecific neutralizing antibodies can be induced in a potential vaccine formulation.

v

Offline veritas

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Re: Could this be the holy grail ?
« Reply #413 on: September 05, 2009, 10:31:05 AM »
Keystone report:

http://www3.niaid.nih.gov/topics/HIVAIDS/Research/vaccines/reports/Keystone2009.htm



"With these insights, investigators hope to construct an immunogen that stimulates a neutralizing antibody response"

v

Offline veritas

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Re: Could this be the holy grail ?
« Reply #414 on: September 05, 2009, 04:29:01 PM »

The link has been found between the potent antibodies PG9 and PG16 and anti-ps. Follow the story:

The PG9 and PG16 antibodies were discovered by research spearheaded by IAVI  ( The International AIDS Vaccine Initiative) as reported here on AIDSMED and first posted by Carlos3000 on this thread on Sept 3. The link from that post:



http://www.positivelypositive.ca/hiv-aids-news/IAVI-Two_New_Antibodies_Found_to_Cripple_HIV.html

IAVI is part of the Global Aids Vaccine Initiative.

CHAVI is researching anti-ps as part of their quest for a cure and a vaccine. They brought in Dr. Philip Thorpe's lab as part of their consortium:

http://humanvaccine.duke.edu/modules/haynes_vdc/index.php?id=2

Dr.Thorpe is the "father" of anti-ps.

In 2008, CHAVI and IAVI  joined to collaborate on HIV vaccine research and to focus on four key areas. One of those focus areas was:

"Examining the possible reasons why some people who are exposed to HIV do not progress to AIDS"



http://www.medicalnewstoday.com/articles/104371.php

Couple all the above, with J220's link, showing that liposomes  (phosphalipids) can induce antibodies:


http://www.sciencedaily.com/releases/2009/09/090901143319.htm

We have the connection !!!!!

IT'S HAPPENING !!!!!!

v

Offline leit

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Re: Could this be the holy grail ?
« Reply #415 on: September 06, 2009, 01:17:33 AM »

IT'S HAPPENING !!!!!!

Yes, your sci-fi delirium. So what else is new?


Offline sensual1973

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Re: Could this be the holy grail ?
« Reply #416 on: September 06, 2009, 01:43:43 AM »
its like taking a pill of Xanax to feel good.
discussing something that is not even in Phase 0 .
God grant me the serenity to accept the things i can not change.

Offline leit

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Re: Could this be the holy grail ?
« Reply #417 on: September 06, 2009, 02:42:22 AM »
its like taking a pill of Xanax to feel good.

More than one and not exactly Xanax, one would say...

Quote
discussing something that is not even in Phase 0 .

Please note also that the DONOR HIMSELF "did not benefit appreciably from the antibodies [PG9 and PG16, that make him an 'elite neutralizer' - LOL]" (http://www.sciencemag.org/cgi/content/full/325/5945/1195)!!!
« Last Edit: September 06, 2009, 02:44:48 AM by leit »

Offline veritas

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Re: Could this be the holy grail ?
« Reply #418 on: September 06, 2009, 04:58:13 AM »

leit,

I seee your back to reading this thread. You couldn't stay away? I also see that your understanding of the science is still muted about the advances being made by IAVI, CHAVI and the Global  Aids Initiative.
Also, I see you still don't have any amunition to counter-debate the science posted. Your no -response to Inchlingblue's Tag-link and your response here for emotional yuks shows your colors. If you believe that this thread is science fiction, there is a simple solution------ DON'T READ IT!
I await with bated breath your next utterance!

v


Offline veritas

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Re: Could this be the holy grail ?
« Reply #419 on: September 06, 2009, 05:06:35 AM »

Offline tommy246

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Re: Could this be the holy grail ?
« Reply #420 on: September 06, 2009, 05:47:36 AM »
Veritas this is very exciting news keep up your excellent work keeping us all informed i am an optimist and a realist and feel were getting close.
jan 06 neg
dec 08 pos cd4 505 ,16%, 1,500vl
april 09 cd4 635 ,16%,60,000
july 09 ,cd4 545,17%,80,000
aug 09,hosptal 18days pneumonia cd190,225,000,15%
1 week later cd4 415 20%
nov 09 cd4 591 ,vl 59,000,14%,started atripla
dec 09  cd4 787, vl 266, 16%
march 2010  cd4 720 vl non detectable -20  20%
june 2010  cd4  680, 21%, ND

Offline veritas

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Re: Could this be the holy grail ?
« Reply #421 on: September 06, 2009, 08:13:01 AM »

tommy246,

Thanks for your post. I believe within the next two months a lot of what I posted on this thread will become a lot clearer.
 I'm following this reseach as close as I can and I thank a lot of the members here who have found and contributed information that I have missed. At the very least, this thread shows the Global co-operation that is happening with respect to HIV research, something that should have been done 20 years ago.

I,like you, am an optimist and what really intrigues me about this research is the new anti-ps paradigm which uncloaks the virus from the immune system. The findings of more potent killer antibodies will be,I believe, the  perfect coupling with anti-ps to do damage to the virus.

Never, ever,ever give up. I'll follow this research to it's logical conclusion.

"The wok goes on!"

v

Offline xman

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Re: Could this be the holy grail ?
« Reply #422 on: September 06, 2009, 11:13:39 AM »
.
« Last Edit: September 07, 2009, 01:28:50 PM by xman »
sign the petition launched by the aids policy project addressed to the nih aimed to increase the money needed to find the cure:

http://www.aidspolicyproject.org/petition_for_the_nih

we can make a difference and we need to fight. please support them! it doesn't cost you anything. they need it now more than ever!

Offline brazilianman

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Re: Could this be the holy grail ?
« Reply #423 on: September 06, 2009, 11:29:18 AM »
 :'(

worst of human beings.
no shine and want to delete the brightness of others.
no hope and want the others have not.
not faith and ridicules the faith of others.


 :'(

Offline georgep77

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Re: Could this be the holy grail ?
« Reply #424 on: September 06, 2009, 01:04:46 PM »
veritas wants to enter the guiness book. he continues until the release of this one counting more than 2 billion replies on this thread of course all from himself to be awarded for the longest internet thread ever made.
To:  "Justice League" super friends: super xman & wonder leit

veritas ur thread is awesome, don't give up.
Come on Sangamo,  Geovax,  Bionor immuno, ...Make us happy !!!
+ 2008

Offline leit

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Re: Could this be the holy grail ?
« Reply #425 on: September 06, 2009, 07:02:50 PM »

:'(

worst of human beings.
no shine and want to delete the brightness of others.
no hope and want the others have not.
not faith and ridicules the faith of others.


 :'(

Oh, original BRAZILIAN MACUMBA!!! What a fright. ROTFL!


Offline anniebc

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Re: Could this be the holy grail ?
« Reply #426 on: September 06, 2009, 07:16:53 PM »
Leit/Xman

If you don't agree with anything Veritas has to say or have nothing constructive to say then stay away from his thread..ridiculing other posters is not allowed, and childish behaviour is just, well...childish.

So unless you have somthing to say that has anything to do with the subject being discussed here then stay out of this discussion.

Jan

« Last Edit: September 06, 2009, 07:19:53 PM by anniebc »
-----------------------------------------------------------------------
Never knock on deaths door..ring the bell and run..he really hates that.

Offline brazilianman

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Re: Could this be the holy grail ?
« Reply #427 on: September 06, 2009, 07:25:46 PM »
leit

is not voodoo. is a tragic conclusion. not like the veritas writes. simply not read. very like.

Offline leit

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Re: Could this be the holy grail ?
« Reply #428 on: September 06, 2009, 07:32:23 PM »

veritas ur thread is awesome, don't give up.

"veritas" who??? "The Pied Piper of Hamelin"? And are you a rat or a child? ROTFL!


Offline anniebc

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Re: Could this be the holy grail ?
« Reply #429 on: September 06, 2009, 07:39:42 PM »
Concider this a warning Leit.

Just in case you missed my last post to you here it is again:

Quote
Leit/Xman

If you don't agree with anything Veritas has to say or have nothing constructive to say then stay away from his thread..ridiculing other posters is not allowed, and childish behaviour is just, well...childish.

So unless you have somthing to say that has anything to do with the subject being discussed here then stay out of this discussion.

Jan
-----------------------------------------------------------------------
Never knock on deaths door..ring the bell and run..he really hates that.

Offline leit

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Re: Could this be the holy grail ?
« Reply #430 on: September 06, 2009, 07:44:34 PM »

unless you have somthing to say that has anything to do with the subject being discussed here then stay out of this discussion.

Has the following "Science" editorial nothing to do with the subject (please note uppercase bold)?
----

Science 4 September 2009
Vol. 325. no. 5945, p. 1195


POTENT HIV ANTIBODIES SPARK VACCINE HOPES

Jon Cohen

If HIV/AIDS researchers had a wish list, at the very top would sit a vaccine that could teach the body to make potent antibodies against the many strains of the virus. Despite 25 years of effort, no such vaccine is in sight, but now they are a step closer. A large team of researchers has identified the most powerful, broad-acting antibodies yet against multiple strains of the virus.

Finding good antibodies is a far cry from developing a vaccine that prods the immune system to produce them. But "broadly neutralizing antibodies" (bNAbs) are rare: Researchers have identified only a half-dozen to date. Now an international group funded mainly by the International AIDS Vaccine Initiative (IAVI) has discovered two new ones that have an unusual potency. "This has actually made me quite optimistic-for once," says Dennis Burton, an immunologist at the Scripps Research Institute in San Diego, California, who led the research effort.

For many years, Burton says, he thought that if an antibody had a broader reach, it inevitably would be weaker. "I wondered whether there would be any antibody better than the ones we had," he says. "Well, these are."

Burton, his graduate student Laura Walker, and 33 other researchers report online 3 September in Science (www.sciencemag.org/cgi/content/abstract/1178746) that the two new antibodies have unusual characteristics that open new avenues of AIDS vaccine research. "It's a great paper that describes very novel antibodies," says immunologist John Mascola of the Vaccine Research Center at the National Institute of Allergy and Infectious Diseases in Bethesda, Maryland.

The researchers first collected blood from some 1800 HIV-infected people in Africa, Asia, Europe, and North America. Using novel techniques, they identified 10% who had antibodies that could derail more than a dozen different strains of the virus. This paper focuses on one sub-Saharan African donor; THE PERSON DID NOT BENEFIT APPRECIABLY FROM THE ANTIBODIES, WHICH ARE NO MATCH FOR HIV ONCE AN INFECTION IS ESTABLISHED.

The researchers sifted through a staggering 30,000 antibody-producing B cells from the donor and isolated two monoclonal antibodies, dubbed PG9 and PG16, that could prevent infection in more than 70% of 162 viral strains tested in cell culture. Not only were they broad acting, but the antibodies worked at minute levels-a magnitude lower than the four best characterized bNAbs so far. "It's an enormous amount of work-a tour de force," says AIDS vaccine researcher Ronald Desrosiers, head of the New England Primate Research Center in Southborough, Massachusetts.

On a more sobering note, many researchers have tried to make vaccines that elicit previously identified bNAbs. "In the last 5 years, there have been intensive efforts, and no one has succeeded," Burton says.

Still, Burton and others hope that understanding the unusual way that PG9 and PG16 stop the virus will provide new leads for AIDS vaccine designers. Specifically, HIV's surface proteins attach to immune cells to establish infections. The surface proteins naturally occur in clusters of three, or trimers, and PG9 and PG16 work only against the trimer. Other bNAbs bind to trimers as well as single surface proteins, or monomers. So this suggests that if a vaccine can present the surface proteins to the immune system in the trimeric form, it may have extra punch. It might also help explain why several AIDS vaccines that contain monomeric surface proteins have performed poorly.

Wayne Koff, who heads research and development at IAVI, says PG9 and PG16 are the first of several new bNAbs that he predicts will help guide the field. In particular, researchers hope the antibodies might help crystallographers finally elucidate the structure of a trimer, which occupies another slot on the wish list. "The machine is built and ready to crank out a lot more-and it's very likely to," says Koff.
« Last Edit: September 06, 2009, 07:48:15 PM by leit »

Offline anniebc

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Re: Could this be the holy grail ?
« Reply #431 on: September 06, 2009, 07:53:17 PM »
Yes it has so I suggest you continue to stick to the subject and stop posting crap like this:

Quote
veritas" who??? "The Pied Piper of Hamelin"? And are you a rat or a child? ROTFL!

OR THIS

Quote
Oh, original BRAZILIAN MACUMBA!!! What a fright. ROTFL!

Jan
-----------------------------------------------------------------------
Never knock on deaths door..ring the bell and run..he really hates that.

Offline GNYC09

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Re: Could this be the holy grail ?
« Reply #432 on: September 06, 2009, 07:56:27 PM »
Oh, original BRAZILIAN MACUMBA!!! What a fright. ROTFL!

This comment is absolutely racist!  I'm surprised it's not deemed worthy of an immediate ban, particularly since Leit has repeatedly disparaged another member - one that actually contributes valuable information might I add. Admins, please reconsider.

Offline anniebc

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Re: Could this be the holy grail ?
« Reply #433 on: September 06, 2009, 08:41:55 PM »
"The word "macumba" is frequently used in Brazil to refer to any ritual or religion of African origin (as slang), and although its use by non-practitioners remains largely pejorative in intent (referring to all sorts of religious (or otherwise) superstitions and luck-related rituals and beliefs), and is considered offensive"

Leit This is your final warning, any more negative post's from you will result in a TO...and an apology to Brazillianman wouldn't go amiss either.

Jan
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Never knock on deaths door..ring the bell and run..he really hates that.

Offline leit

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Re: Could this be the holy grail ?
« Reply #434 on: September 07, 2009, 02:57:23 AM »

"The word "macumba" is frequently used in Brazil to refer to any ritual or religion of African origin (as slang), and although its use by non-practitioners remains largely pejorative in intent (referring to all sorts of religious (or otherwise) superstitions and luck-related rituals and beliefs), and is considered offensive"

"...its use among actual practitioners is not viewed negatively. In Brazil one can find expressions such as "chuta que é macumba!" ("kick it out, it is witchcraft!") to show disagreement with bad luck." (http://en.wikipedia.org/wiki/Macumba, your source). So, nothing offensive.

Besides that, what about having been described as "worst of human beings (etc. etc.)" (http://forums.poz.com/index.php?topic=22113.msg354691#msg354691)?

Sorry, Jan, but your intervention is very biased.


Offline veritas

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Re: Could this be the holy grail ?
« Reply #435 on: September 07, 2009, 04:14:27 AM »
 After that short juvenile interruption and speaking of antibodies, it seems the boys at Duke have found and tested more potent anti-lipid antibodies and reported their findings at the aids vaccine 2008 conference. See:

http://www.hivvaccineenterprise.org/conference/archive/2008/Presentations/Thursday/Rapporteurs/1250%20R%20Pantophlet.pdf

The AIDS Vaccine 2008 Conf. was primarily focused on basic research. Much of this was dealing with broadly-neutralizing anti-HIV antibodies. The few, rare, known familiar suspects: 2F5, 2G12, b12, were the subject of hundreds of experiments presented at the conference. It seemed that "the way forward" was thought to be via insights into these promising antibodies, 2 of which bind a lipid and the virus, and one of which (b12) binds a sugar that coats a viral protein. According to other interesting data presented at the conference, the antibody b12 is apparently the most potent of the three. Along comes Duke University's researcher [Dr. Tony Moody], and presents data from CHAVI 005 experiments, showing that they've got an antibody [PPHM-Duke Collab. mab ‘PGN632’, aka ’11.31’] which only binds a lipid. This particularly potent antibody is orders of magnitude more potent than even b12, and in subtype-C HIV viruses, ( a very common subtype), the anti-lipid antibody was over 1000 times more potent than b12, 2F5, and 2G12. If that is not enough of a surprise to the field, to continue the out-of-the-box theme, it turns out that this unprecedented incredibly powerful antibody works by sticking to a lipid on uninfected T cells, causes an increase in the beta chemokines that block the CCR5 receptor, which prevent HIV from entering a cell in the first place.
Pease notice the graphs.
And I wonder what will be discussed here:

AIDS Vaccine 2009 Paris Oct 19-22, 2009
Oct 20
14:00 - 14:25 Regulation of Broadly Neutralizing Antibody Responses: The Initial B Cell Repertoire To HIV-1 Envelope
Barton Haynes, Duke University Medical Center, USA

IT"S HAPPENING!

v
« Last Edit: September 07, 2009, 04:18:01 AM by veritas »

Offline anniebc

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Re: Could this be the holy grail ?
« Reply #436 on: September 07, 2009, 05:32:49 AM »
"...its use among actual practitioners is not viewed negatively. In Brazil one can find expressions such as "chuta que é macumba!" ("kick it out, it is witchcraft!") to show disagreement with bad luck." (http://en.wikipedia.org/wiki/Macumba, your source). So, nothing offensive.

Besides that, what about having been described as "worst of human beings (etc. etc.)" (http://forums.poz.com/index.php?topic=22113.msg354691#msg354691)?

Sorry, Jan, but your intervention is very biased.

Leit..don't get into a pissing contest with me, I'm not in the mood and you will not win...so either stop the name calling and the insults or stay out to this thread, it's your call...end of story I'm done with you.

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Never knock on deaths door..ring the bell and run..he really hates that.

Offline veritas

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Re: Could this be the holy grail ?
« Reply #437 on: September 07, 2009, 09:58:15 AM »
Oh! By the way, if you read my last post concerning anti-lipid antibodies blocking the  CCR5 entry point for HIV. Perhaps you were worried about the X4 entry point? Don't be worried, be happy! Researches have found more anti-lipid antibodies that block X4.  Warning-- this is a long technical read - only for those who are really interested. Don't worry, It's not SCI-FI, IT'S HAPPENING!


http://www.jlr.org/cgi/rapidpdf/jlr.M000372v1.pdf



v
« Last Edit: September 07, 2009, 10:14:51 AM by veritas »

Offline xman

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Re: Could this be the holy grail ?
« Reply #438 on: September 07, 2009, 01:21:18 PM »
I said many times that veritas is making a good job and I know he is doing so for the hope and the relief of everyone here but I sincerely don't understand why he is posting any single step in the progress of this research. Many of the documents are so technical and complicated to be absolutely impossible to understand. A lot of numbers and theories.

Wouldn't it be much easier and better to post only the results from the various conferences which are made every year to have a summary of all this studies? I'm not studying science or medicine so as an infected person i'm only interested in new drugs which treat our disease. The process to make this drug is indeed interesting but honestly not as useful, at least for me.

It's happening. Yes, great. The question remains when? The moderators should inform that those possible treatments are not just behind the corner and that many years would pass until we may use them.
« Last Edit: September 07, 2009, 01:27:49 PM by xman »
sign the petition launched by the aids policy project addressed to the nih aimed to increase the money needed to find the cure:

http://www.aidspolicyproject.org/petition_for_the_nih

we can make a difference and we need to fight. please support them! it doesn't cost you anything. they need it now more than ever!

Offline Inchlingblue

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Re: Could this be the holy grail ?
« Reply #439 on: September 07, 2009, 01:37:20 PM »
I said many times that veritas is making a good job and I know he is doing so for the hope and the relief of everyone here but I sincerely don't understand why he is posting any single step in the progress of this research. Many of the documents are so technical and complicated to be absolutely impossible to understand. A lot of numbers and theories.

Some people like to know the step-by-step process not only the (voila!) final result!

Please don't take this the wrong way because I don't mean it in a bad way but I don't understand why you read this thread if you have so many problems with it. There are threads on these forums that I don't like or I am not interested in and I simply ignore them.

The moderators should inform that those possible treatments are not just behind the corner and that many years would pass until we may use them.

Why should the moderators do that? You are underestimating the readers of these forums. Just because someone is interested in following the science of HIV does not automatically mean that  they think there will be a cure tomorrow or next week (or ever). Give people a little credit. ;)
« Last Edit: September 07, 2009, 01:45:17 PM by Inchlingblue »

Offline xman

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Re: Could this be the holy grail ?
« Reply #440 on: September 07, 2009, 01:38:45 PM »
Leit/Xman

If you don't agree with anything Veritas has to say or have nothing constructive to say then stay away from his thread..ridiculing other posters is not allowed, and childish behaviour is just, well...childish.

So unless you have somthing to say that has anything to do with the subject being discussed here then stay out of this discussion.

Jan



anniebc,

I'm just expressing my scepticism and the fact that this are preclinical studies which mean that they are not even in clinical trials. I'm a bit surprised that the moderators only post in this threads to warn or remember the rules of the forum which is certainly their job but I would appreciate an opinion from you or the more expert members and moderators on this studies and developments.

Most of the members probably don't know the timeline of clinical trials. Moderators should also inform and warn the members that this possible treatments are still out of range and not available for many years.
sign the petition launched by the aids policy project addressed to the nih aimed to increase the money needed to find the cure:

http://www.aidspolicyproject.org/petition_for_the_nih

we can make a difference and we need to fight. please support them! it doesn't cost you anything. they need it now more than ever!

Offline xman

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Re: Could this be the holy grail ?
« Reply #441 on: September 07, 2009, 01:51:27 PM »
Why should the moderators do that? You are underestimating the readers of these forums. Just because someone is interested in following the science of HIV does not automatically mean that  they think there will be a cure tomorrow or next week. Give people a little credit. ;)

please don't missunderstand me but also less expert people read those threads since we are in a public forum. those readers probably don't know that this are studies and not meds near approval. the entusiasm about this one is a bit exaggerated.
sign the petition launched by the aids policy project addressed to the nih aimed to increase the money needed to find the cure:

http://www.aidspolicyproject.org/petition_for_the_nih

we can make a difference and we need to fight. please support them! it doesn't cost you anything. they need it now more than ever!

Offline veritas

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Re: Could this be the holy grail ?
« Reply #442 on: September 07, 2009, 02:38:01 PM »

xman,

I'm going to try to explain to you my motives for following this line of research so closely, since you finally asked in a civil, non-anxiety ridden tone. I believe you are fairly recently infected (correct me if I'm wrong). I understand the fear when someone is newly infected. I, also, understand the sense of urgency that the newly infected have for a kinder and gentler therapy and the longing for a cure. Everyone on this thread has been waiting for a cure in some cases over 25 or more years. Think of the terror that a lot of our members have been through (including myself since 1991) when your Doctor tells you there are no medications or AZT is the only therapy I can give you and if your virus mutates......
thats terror. Couple that with researchers fighting over who was the first to find the virus rather than co=operating to find more therapies to combat the disease while all your friends die around you. That's terror! I'm not minimizing your concerns when I write this, but if one is infected today there are plenty of medications available without the horrible AE's of years past. To long term survivors, your sense of urgency, although understandable, can be trying.
Now to this thread. I've mentioned many times here that I believe anti-ps, being a new way to attack the virus (a new paradigm), has the potential to be the breakthrough we have all been waiting for since its' target is a non-mutatable portion of the virus. The global co-operation, with respect to the advancement of this therapy, is simply amazing!
Do I know for eure that this therapy is what we all have been waiting for? Of course not,only the completion of the clinical trials will tell us that. Most of the other therapies(not all) are me too drugs going after the same target --- the virus it self. For the past 25yrs the virus has always been able to outsmart the direct attack by mutating. If anti-ps works,the virus will have no defense, since the target is non-mutatable. Perhaps "The Holy Grail". I'll follow this research to lts' conclusion and should the grail be elusive, i'll close this thread and go on to the next best possibility.

But as for now "IT'S HAPPENING! "

 I hope you now understand my motives.

v

Offline brazilianman

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Re: Could this be the holy grail ?
« Reply #443 on: September 07, 2009, 03:19:39 PM »

veritas

good history of life.
you are a survivor.
like a lot of people like you.
'm the same.


this is anti-lipid?

Sugary Achilles' Heel Raises Hope For Broad-Acting Antiviral Drugs

http://www.sciencemag.org/cgi/content/summary/325/5945/1200-a 

sorry bad English

Offline xman

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Re: Could this be the holy grail ?
« Reply #444 on: September 07, 2009, 03:41:41 PM »
veritas,

I never doubt about the reasons of your entusiasm in this study and the theory for now indicates a high rate of success. However since this is still preliminary wouldn't it be more wise to concentrate our attention to those possible treatments in advanced clinical testing? I for example have big hope in the Virxsys candidate. It is now in phase II clinical testing and received fast track status from FDA. At least we have here more hope to see something in the next years than this alternative about monoclonal antibodies. Since this is a complicate issue more research is needed and this will take years.

To your comments about me, yes I was infected relatively recently and I fear everyday about the things to come. I know the meds used to today but there are still unknown long term toxicities which deserve concern. Lipodystrophy for example isn't yet totally eliminated even if the new meds are not directly linked to it. If it wouldn't be for the toxicities an immediate begin for treatment would be recommended but we still need to balance the effectiveness of this meds against the possible side effects.

We need better treatments and we need them soon. We can't wait anymore. I'm not on treatment yet but I don't know for how long. This new approaches are great but they are too far away for practical applicance. I'm reading horror stories about those who have developed resistance to much of the meds and those who have initial signs of lipoatrophy after only a few years of treatment. Others needs to stop because unable to live a normal life. This is a sign that the current meds have huge limitations and it makes me angry that in all this years for complacenty low improvement was archieved.

It surprises me even more that after all the disappointments in HIV research over the recent years so much optimism is still around. Many here are very skeptical like me that something potent will pan out soon and the reason is that for years we're hearing that the cure is far away and perhaps never available. It is upsetting and all this entusiasm about new findings when in the meantime hundreds of infected are dying due to the lack of medicines.
« Last Edit: September 07, 2009, 03:48:52 PM by xman »
sign the petition launched by the aids policy project addressed to the nih aimed to increase the money needed to find the cure:

http://www.aidspolicyproject.org/petition_for_the_nih

we can make a difference and we need to fight. please support them! it doesn't cost you anything. they need it now more than ever!

Offline georgep77

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Re: Could this be the holy grail ?
« Reply #445 on: September 07, 2009, 05:04:09 PM »
I for example have big hope in the Virxsys candidate. It is now in phase II clinical testing and received fast track status from FDA.
I respect & understand your point of view xman, perhaps you can begin a new thread about virxsys.

                         :)
Come on Sangamo,  Geovax,  Bionor immuno, ...Make us happy !!!
+ 2008

Offline veritas

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Re: Could this be the holy grail ?
« Reply #446 on: September 07, 2009, 05:04:37 PM »

xman,

I can see from your response, that perhaps you don't reaaly know how these forums and threads work
This forum is dedicated to reseach. This particular thread which I started is dedicated to anti-ps, because that is the research I am interested in. If this research is not giving you what you need, then there are a number of things you can do:
1. Do your own research.

2. Start your own thread.

3. Go to another thread more in-line with your interests.

4. Read about the latest treatment news provided by Aidsmeds.

5. Go to other sights  and read their news.


As far as this thread is concerned, I am only going to post about research concerning anti-ps. I ask that  you do the same if you come to this thread. Again, if this research doesn't interest you then this thread is not for you. I am not going to discuss this any further.

v

Offline veritas

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Re: Could this be the holy grail ?
« Reply #447 on: September 07, 2009, 05:12:36 PM »

brazilianman,

I don' believe that is anti- ps. There was not enough information for me to follow-up.

v

Offline veritas

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Re: Could this be the holy grail ?
« Reply #448 on: September 08, 2009, 12:53:50 PM »

By the way, how's Bavituximab doing on the cancer front? How about nearing completion in Phase 2 !!!
This shows Bavituximab is not only safe in humans to this point, but also it's method of action (which is the same for anti-viral) is showing efficacy. Is it happening for cancer? You bet!!!

http://finance.yahoo.com/news/Peregrine-Pharmaceuticals-prnews-4025018256.html?x=0&.v=1

Bring on the anti-viral news!

v

Offline veritas

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Re: Could this be the holy grail ?
« Reply #449 on: September 10, 2009, 09:22:03 AM »

Anti-ps antibodies ----- Many applications

http://www.medscape.com/viewarticle/587338

"The current paradigm of aPL holds that they are important in thrombosis, but they may have much wider clinical significance"

A long read  and overview (somewhat technical) ------ with potential far reaching benefits! (hiv is mentioned)

v

 


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