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Author Topic: "Scientists find mechanism for spontaneous HIV cure"  (Read 1123 times)

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Offline tryingtostay

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  • Posts: 285
"Scientists find mechanism for spontaneous HIV cure"
« on: November 04, 2014, 09:51:09 AM »
Well it seems HIV has reached MSN headlines.  No thorough detail on things but it looks like sort of a silencing of the HIV DNA?  I could be wrong.  Removing HIV from the blood plasma was also used but we all know HIV is not limited to the blood plasma so you gotta read between the writers lines.  I'd like to hear more on their findings if it already hasn't been posted

LINK

It's a short read.  Ok here.  I'll post it, heh.

French scientists on Tuesday unveiled the genetic mechanism by which they believe two men were spontaneously cured of HIV, and said the discovery may offer a new strategy in the fight against AIDS.

In both asymptomatic men, the AIDS-causing virus was inactivated due to an altered HIV gene coding integrated into human cells, they wrote in the journal Clinical Microbiology and Infection.

This, in turn, was likely due to stimulation of an enzyme that may in future be targeted for drug treatment to induce the same response, they said.

"This finding represents an avenue for a cure," study co-author Didier Raoult of the French Institute of Health and Medical Research (Inserm) told AFP.

Neither of the men, one diagnosed HIV positive 30 years ago and the other in 2011, have ever been ill, and the AIDS-causing virus cannot be detected with routine tests of their blood.

In both, the virus was unable to replicate due to DNA coding changes that the researchers proposed were the result of a spontaneous evolution between humans and the virus that is called "endogenisation".

"We propose that HIV cure may occur through HIV endogenisation in humans," they wrote. "We believe that the persistence of HIV DNA can lead to cure, and protection, from HIV."

The approach hitherto has been the opposite: to try and clear all traces of HIV from human cells.

The teams said they did not believe the two patients were unique or that the phenomenon was new.

Offline Almost2late

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  • "The Nutcracker"
Re: "Scientists find mechanism for spontaneous HIV cure"
« Reply #1 on: November 04, 2014, 12:00:53 PM »
Thanks 4 the link  :)... Found another on the same story..

http://www.channelnewsasia.com/mobile/health/scientists-see-mechanism/1452936.html

Btw, I found the msn story a bit misleading...The link I posted was a little more thorough.
« Last Edit: November 04, 2014, 12:15:56 PM by Almost2late »
"Every man has his own destiny: the only imperative is to follow it, to accept it, no matter where it leads him." - Henry Miller

http://www.youtube.com/watch?v=ZBkwPYq4nhQ

“Nothing in the world can one imagine beforehand, not the least thing, everything is made up of so many unique particulars that cannot be forseen.” - Nostradamus

Offline tryingtostay

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  • Posts: 285
Re: "Scientists find mechanism for spontaneous HIV cure"
« Reply #2 on: November 04, 2014, 12:18:34 PM »
The only thing I see as beneficial is the fact that the article reached MSN headlines.  HIV needs all the publicity, recognition, and awareness it can get, still.  IMO that's all this article/report was worth.

Offline Giancarlo

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  • Posts: 14
Re: "Scientists find mechanism for spontaneous HIV cure"
« Reply #3 on: November 04, 2014, 12:24:14 PM »
Nov 2011: HIV-
Jul 2012: HIV+
Aug 2012: VL 8,900 / CD4 822 (28%)
Oct 2012: VL 13,500 / CD4 887 (30%)
Jul 2013: VL 9,000 / CD4 ?
Sep 2013: VL 24,000 / CD4 625 (34%)
Oct 11th 2013: Start Atripla
Nov 7th 2013: VL 84 / CD4 665 (37%)
Dec 11th 2013: VL UD (<40) / CD4 960 (35%)

Offline Almost2late

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  • Posts: 483
  • "The Nutcracker"
Re: "Scientists find mechanism for spontaneous HIV cure"
« Reply #4 on: November 04, 2014, 12:32:08 PM »
The only thing I see as beneficial is the fact that the article reached MSN headlines.  HIV needs all the publicity, recognition, and awareness it can get, still.  IMO that's all this article/report was worth.

I agree, but to someone like myself, not very educated on this stuff, the story reads like a cure may have been found  :-\
"Every man has his own destiny: the only imperative is to follow it, to accept it, no matter where it leads him." - Henry Miller

http://www.youtube.com/watch?v=ZBkwPYq4nhQ

“Nothing in the world can one imagine beforehand, not the least thing, everything is made up of so many unique particulars that cannot be forseen.” - Nostradamus

Offline tryingtostay

  • Member
  • Posts: 285
Re: "Scientists find mechanism for spontaneous HIV cure"
« Reply #5 on: November 04, 2014, 12:43:46 PM »
I was just saying.  Now that I look back at the article I posted, I personally I kinda regret posting such junk.  It was just exciting to see HIV in a headline on MSN.

It mentions the HIV is inactive because of 'HIV endogenisation' but isn't there a parallel problem with HIV, also?  The latent HIV?  They should use that Ssu72 protein recently found Article to see if it can kick-off HIV replication with these "spontaneously cured" people.

The best thing going is CRISPR-Cas9
« Last Edit: November 04, 2014, 12:45:49 PM by tryingtostay »

Offline tryingtostay

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  • Posts: 285
Re: "Scientists find mechanism for spontaneous HIV cure"
« Reply #6 on: November 04, 2014, 12:44:14 PM »
whoops

Offline Giancarlo

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  • Posts: 14
Re: "Scientists find mechanism for spontaneous HIV cure"
« Reply #7 on: November 04, 2014, 03:48:41 PM »
I find the study pretty exciting, although I don't think I understand half of it.
Scientists seem to have found a new mechanism that explains why some elite controllers are actually elite controllers. That's new knowledge on how the human body can fight HIV. That's a brand new research avenue which is being opened, one that can potentially lead to a cure for some of us, someday.
So I guess that was worth posting...
« Last Edit: November 04, 2014, 03:51:22 PM by Giancarlo »
Nov 2011: HIV-
Jul 2012: HIV+
Aug 2012: VL 8,900 / CD4 822 (28%)
Oct 2012: VL 13,500 / CD4 887 (30%)
Jul 2013: VL 9,000 / CD4 ?
Sep 2013: VL 24,000 / CD4 625 (34%)
Oct 11th 2013: Start Atripla
Nov 7th 2013: VL 84 / CD4 665 (37%)
Dec 11th 2013: VL UD (<40) / CD4 960 (35%)

Offline Markmt

  • Member
  • Posts: 179
Re: "Scientists find mechanism for spontaneous HIV cure"
« Reply #8 on: November 05, 2014, 01:45:06 AM »
I thought elite controllers secret was a naturally occurring missing CCr5 receptor that Sangamo (and others) are presently working on through gene therapy. So this enzyme could be an addition to this? or elite controllers have more then one reason to be such?
"Live to love and love to live."

Leo Buscaglia

 


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