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Author Topic: LTNP monotherapy ?  (Read 9760 times)

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Offline John2038

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Re: LTNP monotherapy ?
« Reply #50 on: May 29, 2008, 12:52:56 PM »
Still, you're making a lot of assumptions here.

Maybe you will agree that the assumptions made here are not too far from those made for the Kaletra monotherapy study.

I would suggest that if an LTNP showed persistent failure to control HIV, treatment decisions taken with a doctor would be start with a minimal medication burden, not triple-drug therapy, as you suggest.

Ok, but why then not a monotherapy ?
What is interesting is that you are suggesting also a minimal medication burden.

Even if triple-drug therapy was started, there are combinations like NVP+FTC+TFV that do not jack up triglycerides or impose other cardiac risk.

That's the last possibility for sure.

Don't you think watching closely their counts, LTNP can "predict" (in term of probability) a "body failure" for sooner or later ?
What will be the cost of being on monotherapy let say even 2 years earlier ?
Maybe 2 y earlier + mono will work 10 y,  while 2y after + HAART will work just 3 years, because in the meantime, the body is no more able to give his full.

I don't know, but thank's for answering. I appreciate your point of views.

John
« Last Edit: May 29, 2008, 12:54:29 PM by John2038 »

Offline John2038

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Re: LTNP monotherapy ?
« Reply #51 on: May 29, 2008, 12:53:31 PM »
So cutting edge technology is available, but adequate medical training is not?  Interesting.

I would suggest you to travel to have an opinion on that.

Offline Dachshund

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Re: LTNP monotherapy ?
« Reply #52 on: May 29, 2008, 12:57:09 PM »
Seems like you're trying to have it both ways. When it's convenient you post you're at the mercy of doctors without cutting edge skills, and the next post you're relating advanced testing and labs with an amazing turn around time. The rest of the developed world should have it so bad.
http://forums.poz.com/index.php?topic=20963.msg268848#msg268848

Did you read The Little Boy Who Cried Wolf yet?

Offline thunter34

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Re: LTNP monotherapy ?
« Reply #53 on: May 29, 2008, 12:58:29 PM »
I would suggest you to travel to have an opinion on that.

Don't need to, darling.  I'm basing that on your own statements:

Quote
As I am working in a developing country, and as at least the docs here do not have cutting edges skills, I have to raise what seems to me the rights questions.


kthxbye!

AIDS isn't for sissies.

Online Miss Philicia

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Re: LTNP monotherapy ?
« Reply #54 on: May 29, 2008, 01:02:09 PM »
And to think that in another thread John read me for daring to question the qualifications of a doctor in Grenada.  Oh the irony (and the agony).
"Iíve slept with enough men to know that Iím not gay"

Offline John2038

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Re: LTNP monotherapy ?
« Reply #55 on: May 29, 2008, 01:07:43 PM »
Travel, and you will see that most of the time, the best docs just expatriate.
There are few exceptions and I meet one, almost cutting edge.

Sonar, and standard labs at least (and even scans) are all available in most if not all developing countries.
« Last Edit: May 29, 2008, 01:10:33 PM by John2038 »

Online Miss Philicia

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Re: LTNP monotherapy ?
« Reply #56 on: May 29, 2008, 01:11:28 PM »
If I attempted to post something like this from my Palm Treo it would take me 5 hours.
"Iíve slept with enough men to know that Iím not gay"

Offline John2038

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Re: LTNP monotherapy ?
« Reply #57 on: May 29, 2008, 01:15:27 PM »
Easy if your laptop is connected to your Palm (HSDPA).
Logout to avoid unnecessary connection.

Pathetic

Offline Dachshund

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Re: LTNP monotherapy ?
« Reply #58 on: May 29, 2008, 01:19:33 PM »
Travel, and you will see that most of the time, the best docs just expatriate.
There are few exceptions and I meet one, almost cutting edge.

Sonar, and standard labs at least (and even scans) are all available in most if not all developing countries.

I have travelled extensively. I've gone native in Sumatra and lived on less than a couple of bucks a day all over Asia. Oh I've done the third world and not isolated in tourist hot spots. One thing I do know from the Phillipines to Peru those with access to good healthcare like you describe are the privileged and the children of the privileged.

The tests you mention may be available but they ain't available to everyone. I know, I've been there.

Offline John2038

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Re: LTNP monotherapy ?
« Reply #59 on: May 29, 2008, 01:23:24 PM »
The tests you mention may be available but they ain't available to everyone. I know, I've been there.

So ?
« Last Edit: May 29, 2008, 01:26:14 PM by John2038 »

Offline Basquo

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Re: LTNP monotherapy ?
« Reply #60 on: May 29, 2008, 01:24:54 PM »
Good God, man, how much of each day are you spending obsessing over monotherapy for LTNPs?

How about this:  I'm ALMOST considered a LTNP. I take valcyclovir, an antiviral, everyday.  My counts are all good.  So SOME type of monotherapy MIGHT be beneficial.

Please relax. You'll waste the many years you have ahead of you if don't just live with this instead of keeping it under your microscope 24/7.  You'll probably disagree with that but what else do I have to go on? When was the last time you started a thread in off-topic?

And please don't ask me a bunch of IF and HOW and WHY questions about my progression, my medication, etc.

I'm going over to the "Gatherings" forum now. It's something to look forward to, not to agonize over.

Offline thunter34

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Re: LTNP monotherapy ?
« Reply #61 on: May 29, 2008, 01:25:06 PM »
AIDS isn't for sissies.

Offline Dachshund

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Re: LTNP monotherapy ?
« Reply #62 on: May 29, 2008, 01:28:06 PM »
So ?

So I know when someone is full of it.

Online Miss Philicia

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Re: LTNP monotherapy ?
« Reply #63 on: May 29, 2008, 01:29:11 PM »
Good God, man, how much of each day are you spending obsessing over monotherapy for LTNPs?

He doesn't even know if he's actually a LTNP in the first place.  And this word "obsessive" keep coming up, doesn't it?
"Iíve slept with enough men to know that Iím not gay"

Offline redhotmuslbear

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Re: LTNP monotherapy ?
« Reply #64 on: May 29, 2008, 01:30:15 PM »
And please don't ask me a bunch of IF and HOW and WHY questions about my progression, my medication, etc.

I'm going over to the "Gatherings" forum now. It's something to look forward to, not to agonize over.


Oh, no, she di'int go AAAALLLLLLLLL up in there!   ::)
"The real problem is not whether machines think but whether men do." - BF Skinner
12-31-09   222wks VL  2430 CD4 690 (37%)
09-30-09   208wks VL  2050  CD4 925 (42%)
06-25-08   143wks VL  1359  CD4 668 (32%)  CD8 885
02-11-08   123wks off meds:  VL 1364 CD4 892(40%/0.99 ratio)
10-19-07   112wks off meds:   VL 292  CD4 857(37%/0.85 ratio)

One copy of delta-32 for f*****d up CCR5 receptors, and an HLA B44+ allele for "CD8-mediated immunity"... beteer than winning Powerball, almost!

Offline John2038

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Re: LTNP monotherapy ?
« Reply #65 on: May 29, 2008, 01:33:15 PM »
Without hijacking, such thread would become much shorter and involve only the interested people without bothering the others.
beeeeee
« Last Edit: May 29, 2008, 01:35:44 PM by John2038 »

Offline John2038

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Re: LTNP monotherapy ?
« Reply #66 on: May 29, 2008, 01:34:34 PM »
"obsessive" keep coming up, doesn't it?

Narcissism as/and self-descriptive
« Last Edit: May 29, 2008, 01:42:48 PM by John2038 »

Offline thunter34

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Re: LTNP monotherapy ?
« Reply #67 on: May 29, 2008, 02:00:59 PM »
Narcissism as/and self-descriptive

interesting.  this post was grammatically correct english until you came back and revised it. 

it said "narcissistic and self-descriptive". 
AIDS isn't for sissies.

Offline David_CA

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Re: LTNP monotherapy ?
« Reply #68 on: May 29, 2008, 02:03:40 PM »
Without hijacking, such thread would become much shorter and involve only the interested people without bothering the others.
beeeeee

John, what do you want?  Do you want to throw your thoughts and ideas out and get our opinions on them or do you want validation / agreement?  If it's the former, you're getting them.  It does no good to argue with other's opinions.  If it's the latter, you won't get it. 

I've generally found that the forum works like this (for HIV related questions, anyway)
1. I ask a question
2. People respond
3. I may ask them to elaborate on what they've said
4. Others will agree or disagree with what others have said
5. I read all the responses and try to learn from them
6. I appreciate when people take time to answer my questions
7. As a rule, I don't argue with those who have lots more HIV / AIDS experience than me
8. I don't burn bridges.  The same people you argue with will be the ones who can help you with serious, relevant questions when you have them. 


David
Black Friday 03-03-2006
03-23-06 CD4 359 @27.4% VL 75,938
06-01-06 CD4 462 @24.3% VL > 100,000
08-15-06 CD4 388 @22.8% VL >  "
10-21-06 CD4 285 @21.9% VL >  "
  Atripla started 12-01-2006
01-08-07 CD4 429 @26.8% VL 1872!
05-08-07 CD4 478 @28.1% VL 740
08-03-07 CD4 509 @31.8% VL 370
11-06-07 CD4 570 @30.0% VL 140
02-21-08 CD4 648 @32.4% VL 600
05-19-08 CD4 695 @33.1% VL < 48 undetectable!
08-21-08 CD4 725 @34.5%
11-11-08 CD4 672 @39.5%
02-11-09 CD4 773 @36.8%
05-11-09 CD4 615 @36.2%
08-19-09 CD4 770 @38.5%
11-19-09 CD4 944 @33.7%
02-17-10 CD4 678 @39.9%  
06-03-10 CD4 768 @34.9%
09-21-10 CD4 685 @40.3%
01-10-11 CD4 908 @36.3%
05-23-11 CD4 846 @36.8% VL 80
02-13-12 CD4 911 @41.4% VL<20
You must be the change you want to see in the world.  Mahatma Gandhi

Offline John2038

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Re: LTNP monotherapy ?
« Reply #69 on: May 29, 2008, 02:17:49 PM »
interesting.  this post was grammatically correct english until you came back and revised it. 

it said "narcissistic and self-descriptive". 

Just update the poz.com dictionary as narcissistic is not in it. In doubt, I corrected it.

John, what do you want?  Do you want to throw your thoughts and ideas out and get our opinions on them or do you want validation / agreement?  If it's the former, you're getting them.  It does no good to argue with other's opinions.  If it's the latter, you won't get it. 

You get answers among hijack. I would love to post in the ideal forum you are describing.
Re-read this thread, you will see that I have ask a question, and answered adequately to those who have answered.
I do not hijack any thread, and I do usually react late to hijack posts, or sometime not at all.

Offline David_CA

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Re: LTNP monotherapy ?
« Reply #70 on: May 29, 2008, 03:12:51 PM »
Just update the poz.com dictionary as narcissistic is not in it. In doubt, I corrected it.

You get answers among hijack. I would love to post in the ideal forum you are describing.
Re-read this thread, you will see that I have ask a question, and answered adequately to those who have answered.
I do not hijack any thread, and I do usually react late to hijack posts, or sometime not at all.

I can't re-read it;  honestly, it gave me a headache the first time.  It must just be me, 'cause my HIV questions generally get answered without much in the way of hijack.

David
Black Friday 03-03-2006
03-23-06 CD4 359 @27.4% VL 75,938
06-01-06 CD4 462 @24.3% VL > 100,000
08-15-06 CD4 388 @22.8% VL >  "
10-21-06 CD4 285 @21.9% VL >  "
  Atripla started 12-01-2006
01-08-07 CD4 429 @26.8% VL 1872!
05-08-07 CD4 478 @28.1% VL 740
08-03-07 CD4 509 @31.8% VL 370
11-06-07 CD4 570 @30.0% VL 140
02-21-08 CD4 648 @32.4% VL 600
05-19-08 CD4 695 @33.1% VL < 48 undetectable!
08-21-08 CD4 725 @34.5%
11-11-08 CD4 672 @39.5%
02-11-09 CD4 773 @36.8%
05-11-09 CD4 615 @36.2%
08-19-09 CD4 770 @38.5%
11-19-09 CD4 944 @33.7%
02-17-10 CD4 678 @39.9%  
06-03-10 CD4 768 @34.9%
09-21-10 CD4 685 @40.3%
01-10-11 CD4 908 @36.3%
05-23-11 CD4 846 @36.8% VL 80
02-13-12 CD4 911 @41.4% VL<20
You must be the change you want to see in the world.  Mahatma Gandhi

Offline John2038

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Re: LTNP monotherapy ?
« Reply #71 on: May 29, 2008, 03:40:39 PM »
I can't re-read it;  honestly, it gave me a headache the first time. 

Beyond your understanding but compliant with your golden rules ?
1. I ask a question
2. People respond
3. I may ask them to elaborate on what they've said
4. Others will agree or disagree with what others have said
5. I read all the responses and try to learn from them
6. I appreciate when people take time to answer my questions
7. As a rule, I don't argue with those who have lots more HIV / AIDS experience than me
8. I don't burn bridges.  The same people you argue with will be the ones who can help you with serious, relevant questions when you have them. 

It must just be me, 'cause my HIV questions generally get answered without much in the way of hijack.

maybe cause of your motobike ?  (trying to answer to your interrogation)
« Last Edit: May 29, 2008, 03:54:52 PM by John2038 »

Offline bocker3

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Re: LTNP monotherapy ?
« Reply #72 on: May 29, 2008, 06:49:40 PM »
John,

You have gotten a number of replies to your question -- redhotmuslebear has answered it about sixteen different ways.  Each time, you have come back and tried to convince him why he's wrong, or closed minded, etc for not agreeing that monotherapy is THE answer.  So, please get off your high horse about hijacks and no answers here.

What I don't understand is WHY ON EARTH ARE YOU OBSESSING ABOUT THIS TOPIC!!!  You are not a LTNP, you've been positive for less than 2 years -- there is nothing long-term about that.  Let me say again -- 2 years is NOT long-term.

Bottom line is that in just about every single thread that I've read from you, you ask a question for which you, seeming do not want HONEST answers -- you simply want answers to match up with your thinking.  This is working the last nerve of a whole host of people -- and you probably don't want to be burning bridges to folks with lots of LONG-TERM experience living with the virus (I do not consider myself one of those -- I was only diagnosed in 2005 and last tested negative in 2001).

Really, I say this with absolute sincerity -- stop obsessing over every thought you think and every study you read.  You will absolutely drive yourself insane.  (Let me pre-empt your next thought -- I'm not advocating "giving up" or turning over all decision to your doctors -- I'm a proponent of owning your own health care, in partnership with your docs -- but you are way overboard here.)

Worry about learning to live with HIV -- hopefully you will get to call yourself a LTNP some day.  Honestly, I don't know how you live with yourself!

Mike
Atripla - Started 12/05
Reyataz/Norvir - Added 6/06
Labs - Pre-Meds
Sep05 T=350/25% VL98,559
Nov05 288/18%  47,564
Current Labs
May2013 691/31% <20

Offline David_CA

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Re: LTNP monotherapy ?
« Reply #73 on: May 29, 2008, 10:42:06 PM »
Beyond your understanding but compliant with your golden rules ?
maybe cause of your motobike ?  (trying to answer to your interrogation)

Well, I'll take that as a compliment!  :D
Black Friday 03-03-2006
03-23-06 CD4 359 @27.4% VL 75,938
06-01-06 CD4 462 @24.3% VL > 100,000
08-15-06 CD4 388 @22.8% VL >  "
10-21-06 CD4 285 @21.9% VL >  "
  Atripla started 12-01-2006
01-08-07 CD4 429 @26.8% VL 1872!
05-08-07 CD4 478 @28.1% VL 740
08-03-07 CD4 509 @31.8% VL 370
11-06-07 CD4 570 @30.0% VL 140
02-21-08 CD4 648 @32.4% VL 600
05-19-08 CD4 695 @33.1% VL < 48 undetectable!
08-21-08 CD4 725 @34.5%
11-11-08 CD4 672 @39.5%
02-11-09 CD4 773 @36.8%
05-11-09 CD4 615 @36.2%
08-19-09 CD4 770 @38.5%
11-19-09 CD4 944 @33.7%
02-17-10 CD4 678 @39.9%  
06-03-10 CD4 768 @34.9%
09-21-10 CD4 685 @40.3%
01-10-11 CD4 908 @36.3%
05-23-11 CD4 846 @36.8% VL 80
02-13-12 CD4 911 @41.4% VL<20
You must be the change you want to see in the world.  Mahatma Gandhi

 


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