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Author Topic: New way to inhibit HIV target is created  (Read 1308 times)

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Offline datdude

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  • Posts: 71
New way to inhibit HIV target is created
« on: May 15, 2008, 07:01:02 PM »
ANN ARBOR, Mich., May 15 (UPI) -- U.S. scientists say they've created what's believed to be the first new mechanism in more than 20 years for treating the human immunodeficiency virus.

Researchers at the University of Michigan said they used computer models to develop a compound that inhibits the HIV protease -- an enzyme that promotes the replication of the virus. The scientists said their achievement might lead to a new class of AIDS drugs.

The study's principal investigator, Professor Heather Carlson, stressed the finding is only a preliminary, yet significant, step.

"It's very easy to make an inhibitor, (but) it's very hard to make a drug," said Carlson. "This compound is too weak to work in the human body. The key is to find more compounds that will work by the same mechanism."

http://www.upi.com/NewsTrack/Science/2008/05/15/new_way_to_inhibit_hiv_target_is_created/4973/

Offline bimazek

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Re: New way to inhibit HIV target is created
« Reply #1 on: May 16, 2008, 02:02:28 AM »

 the first new inhibitor class for HIV protease enzyme since dimerization inhibitors were introduced 17 years ago.
 
 A new way of inhibiting HIV protease Using computer 3D shape maps to identify interactions and the Protein Structure method to incorporate protein flexibility, they generated a receptor-based pharma model of the flexible flap region of the semiopen, state of HIV protease enzyme. interactions were observed at the base of the flap, within a cleft with a specific structural role. In the closed, bound state of HIV protease enzyme, each flap tip docks against the other. This flap-recognition site is filled by the protein and cannot be identified using traditional approaches. Virtual screening and simulations show how small molecules, new medicines, can be identified to fit into this cleft. Subsequent experimental testing confirms inhibitory activity of this new class of inhibitor. A new med is discovered.  This may be the first new inhibitor class for HIV protease enzyme since dimerization inhibitors were introduced 17 years ago.
this is the paper..
 http://www3.interscience.wiley.com/journal/117950125/abstract?CRETRY=1&SRETRY=0
she seems like a really wonderful nice bright person... congrats to her and her team...
http://www.umich.edu/~biophys/facultstaff/research/carlson.html

 


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