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Author Topic: Any drug combinations that work with less side effects?  (Read 2297 times)

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Offline tag_man08

  • Member
  • Posts: 118
  • Keep Dreaming!!!
Any drug combinations that work with less side effects?
« on: April 09, 2008, 03:49:32 PM »
So far I am still off meds, but I am trying to find some information on combinations that work with less side effects...
Is there any info out there?   
08/30/07:  The HIV diagnosis...
09/07/07:  CD4 299 (21%)  VL 160K
01/07/08:  CD4 396 (26%)  VL 125K
04/21/08:  CD4 478 (25%)  VL 92K
09/03/08:  CD4 313 (23%)  VL 10K
11/03/08:  CD4 338 (23%)  VL 30K
11/21/08:  Isentress & Truvada
12/05/08:  CD4 485 (29%)  VL  undetectable in two weeks
03/13/09:  CD4 575 (30%)  VL  undetectable

Offline Fabrizio

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  • Posts: 17
Re: Any drug combinations that work with less side effects?
« Reply #1 on: April 09, 2008, 04:11:03 PM »
Hello,

you can find lots of information about medicines on this and other websites. Two important things to remember are:

- new or newer medication are much better tolerated than the older ones;

- side effects are subjective; the same medicine (and this is also true for a simple aspirin) can have intolerable side effect for some people, while other patients will no experience side effect at all.

Here you will find a great number of hivers who, for example, had no problem with Atripla and many others who had to switch because of severe side effects.

You will decide your combination with your doctor. It's most likely that you will experience mild side effect on most new medicines. Most side effect tend to disappear after a few weeks, as for long term effect...well, this is one of the big question marks in the hiv world but I believe there's reason to be optimistic.

As a "negative partner", I'm more worried about adherence than the early side effects of medications...

fabrizio

 
« Last Edit: April 09, 2008, 04:14:29 PM by Fabrizio »
Worried and Optimistic Negative Partner

Offline BT65

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Re: Any drug combinations that work with less side effects?
« Reply #2 on: April 09, 2008, 04:25:15 PM »
Fabrizio, I'm saying this in the most respectful way; being that you are negative, I would caution you about giving advice to someone who is HIV+.  I could be wrong in saying that, and if I am, I'm sure one of the gods will let me know.

Also, the newer meds are usually reserved for people who have resistance issues.
I've never killed anyone, but I frequently get satisfaction reading the obituary notices.-Clarence Darrow

Offline BlueMoon

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  • Posts: 665
  • Calling from the Fun House
Re: Any drug combinations that work with less side effects?
« Reply #3 on: April 09, 2008, 07:13:43 PM »
It really does vary by individual, and a regimen is also determined by such things as resistance profile and physiological conditions apart from the virus.

I'm sure that as an involved partner of an infected person, Fabrizio is as well-read on HIV as many poz people and qualified to comment.  I don't think HIV bestows any special wisdom on anyone.
...................VL.....CD4.....%
-----------------------------------------
08/10-- ......<40.....290.....42
05/10-- ......<48.....290.....46
02/10-- ......<48.....481.....44
10/09-- ......<48.....277.....46
07/09-- ......<48.....300.....38
05/09-- ........51.....449.....39
03/09-- Added Isentress
02/09-- ........65.....299.....34
11/08-- ........62.....242.....40
08/08-- ........66.....212.....29
05/08-- ......202.....217.....27
03/08-- ....5210.....187.....21
02/08-- Began Truvada/Reyataz/Norvir
12/07-- 273,000.....157.....22
11/07-- 229,000.....209.....22
10/07-- Diagnosis

It's a complex world.

Offline Jeff G

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  • Member
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  • How am I doing Beren ?
Re: Any drug combinations that work with less side effects?
« Reply #4 on: April 09, 2008, 07:19:05 PM »
It really does vary by individual, and a regimen is also determined by such things as resistance profile and physiological conditions apart from the virus.

I'm sure that as an involved partner of an infected person, Fabrizio is as well-read on HIV as many poz people and qualified to comment.  I don't think HIV bestows any special wisdom on anyone.
     

                 Im not so sure about that .

Offline BT65

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Re: Any drug combinations that work with less side effects?
« Reply #5 on: April 09, 2008, 09:32:42 PM »
I'm sure that as an involved partner of an infected person, Fabrizio is as well-read on HIV as many poz people and qualified to comment.  I don't think HIV bestows any special wisdom on anyone.

Well, in another forum, Fabrizio stated that his partner has been HIV+ a year and 1/2 (or something to that effect).  I doubt one can get 'well read' about all the meds in that timeframe to be doling out advice. 
I've never killed anyone, but I frequently get satisfaction reading the obituary notices.-Clarence Darrow

Offline Fabrizio

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Re: Any drug combinations that work with less side effects?
« Reply #6 on: April 10, 2008, 05:32:30 AM »

I'm sorry, I was just trying to help. My point was that regiments vary by individual. I have hardly done something like recomendin one pill or the other.

Newer medication do have less side effects than those used in the 1990s. I did not refer to very new stuff like the chemokine receptor CCR5  entry inhibitor.


Perhaps a year is not a good timeframe to be "doling out advice" but I have voluteered in the hiv world for much longer than that.

This is my last message and I'll be leaving the forum now: jg1962 and Bettytacy please take my apologies for my unacceptable behaviour.

So long,

f.
Worried and Optimistic Negative Partner

Offline Jeff G

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  • Member
  • Posts: 10,810
  • How am I doing Beren ?
Re: Any drug combinations that work with less side effects?
« Reply #7 on: April 10, 2008, 06:15:26 AM »
  Fabrizio.... It is not my wish for you to leave the forums . As far as I am concerned you are more than welcome here . there are many care givers that are are valued members on this site.
You must realize and expect to have a dialog and exchange of ideas here...that is what we do.
Have you considered posting in the... Some one I care about has HIV , section .

I am some what new to the forums myself . Members like bettytacy ( who I don't speak for ) are probably much more qualified to comment on an issue like this one than I am . When I posted my comment " I'm not sure about this " I meant it literally . Hang in there if you want to , there are many outspoken members here that wont be shy about helping you find a comfort zone .

Offline BlueMoon

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  • Calling from the Fun House
Re: Any drug combinations that work with less side effects?
« Reply #8 on: April 10, 2008, 06:57:31 AM »
Well then I guess my six month old diagnosis disqualifies me from participating also.   
...................VL.....CD4.....%
-----------------------------------------
08/10-- ......<40.....290.....42
05/10-- ......<48.....290.....46
02/10-- ......<48.....481.....44
10/09-- ......<48.....277.....46
07/09-- ......<48.....300.....38
05/09-- ........51.....449.....39
03/09-- Added Isentress
02/09-- ........65.....299.....34
11/08-- ........62.....242.....40
08/08-- ........66.....212.....29
05/08-- ......202.....217.....27
03/08-- ....5210.....187.....21
02/08-- Began Truvada/Reyataz/Norvir
12/07-- 273,000.....157.....22
11/07-- 229,000.....209.....22
10/07-- Diagnosis

It's a complex world.

Offline BT65

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Re: Any drug combinations that work with less side effects?
« Reply #9 on: April 10, 2008, 09:00:03 AM »
Fabrizio, I don't want you to go away with your tail between your legs.  Like jg said, we have members who are caregivers who are more than welcome here.  I didn't say you 'couldn't' comment; I was just cautioning you.  Sometimes when someone is HIV+, advice is better taken from someone else who actually is HIV+ than not.  You're more than welcome here.

Well then I guess my six month old diagnosis disqualifies me from participating also.   

This sounds like something my granddaughter would say. 
I've never killed anyone, but I frequently get satisfaction reading the obituary notices.-Clarence Darrow

Offline David_CA

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  • Joined: March 2006
Re: Any drug combinations that work with less side effects?
« Reply #10 on: April 10, 2008, 09:12:27 AM »
I'll risk commenting here, as I've only been on meds for 18 months... but the drugs that are prescribed as 'Preferred Regimens' are described pretty well here www.aidsmeds.com/articles/WhenToStart_4759.shtml.  As one who is only on their first regimen, I can tell you that the short-term side effects from Atripla, what my husband and I take, are very minor for us.  I take an ACE Inhibitor for hypertension, and I feel the side effects from that more than I do than from the Atripla.  Many people cannot tolerate Atripla, but many more can.  Side effects can vary from individual to individual, to an extent.  I'll let others who've been on HAART longer go into further detail, as they certainly have much greater experience.  I will say that the meds for a newly infected person these days are nowhere as bad as the meds that were used back in the early days of AIDS and HIV.  Good luck with it and go through the rest of the lessons listed in the upper left of any of these forum pages.

Fabrizio, don't let other's comments turn you away from the Forums.  You and your partner can benefit a lot from these forums.

David
Black Friday 03-03-2006
03-23-06 CD4 359 @27.4% VL 75,938
06-01-06 CD4 462 @24.3% VL > 100,000
08-15-06 CD4 388 @22.8% VL >  "
10-21-06 CD4 285 @21.9% VL >  "
  Atripla started 12-01-2006
01-08-07 CD4 429 @26.8% VL 1872!
05-08-07 CD4 478 @28.1% VL 740
08-03-07 CD4 509 @31.8% VL 370
11-06-07 CD4 570 @30.0% VL 140
02-21-08 CD4 648 @32.4% VL 600
05-19-08 CD4 695 @33.1% VL < 48 undetectable!
08-21-08 CD4 725 @34.5%
11-11-08 CD4 672 @39.5%
02-11-09 CD4 773 @36.8%
05-11-09 CD4 615 @36.2%
08-19-09 CD4 770 @38.5%
11-19-09 CD4 944 @33.7%
02-17-10 CD4 678 @39.9%  
06-03-10 CD4 768 @34.9%
09-21-10 CD4 685 @40.3%
01-10-11 CD4 908 @36.3%
05-23-11 CD4 846 @36.8% VL 80
02-13-12 CD4 911 @41.4% VL<20
You must be the change you want to see in the world.  Mahatma Gandhi

Offline tag_man08

  • Member
  • Posts: 118
  • Keep Dreaming!!!
Re: Any drug combinations that work with less side effects?
« Reply #11 on: April 10, 2008, 09:14:20 AM »
Thanks for all the comments.  I did not mean to start a debate on who is more qualified to give advise.  To be honest, it doesn't matter to me if you are hiv-/+ if you have some great advise to me since you are a member of this forum.  Your membership alone tells me that you are here to have a positive contribution.  I am still a newbie here to all of this and hoping to make new friends that have much more advise than I have at this time.  I am still learning about it all--inbetween my regular day-to-day activities.  The best advise received to me so far has been from a 34yo female (HIV-) person dealing with her non-HIV issues but dealing with her own disabling disease.  She has been a great influence to my well-being and somewhat stable mind.   :)    I have one HIV+ friend (a 20yr survivor) who also has been a great mentor.  But I am open to new friends too as I grow with all of you here.

I was hoping to hear from others that were on combinations that are working for them with minimal side effects.  I'm still reading about a lot of the drugs and was hoping to find some that others thought were better.  Please continue to post.....
08/30/07:  The HIV diagnosis...
09/07/07:  CD4 299 (21%)  VL 160K
01/07/08:  CD4 396 (26%)  VL 125K
04/21/08:  CD4 478 (25%)  VL 92K
09/03/08:  CD4 313 (23%)  VL 10K
11/03/08:  CD4 338 (23%)  VL 30K
11/21/08:  Isentress & Truvada
12/05/08:  CD4 485 (29%)  VL  undetectable in two weeks
03/13/09:  CD4 575 (30%)  VL  undetectable

Offline J.R.E.

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  • Posts: 7,099
  • Joined Dec-2003 Living positive, since 1985.
Re: Any drug combinations that work with less side effects?
« Reply #12 on: April 10, 2008, 09:42:55 AM »
Hi,

You really won't know, what kind of side effects you will get until you get started on meds. Many people can start and have very few problems, others, not so fortunate.

The doctor may prescribe you Atripla ( for instance) and you may find out 3 months down the road that you can't handle it. Or, the doctor may start you on Viramune combination, and it may screw with your liver. Or you may get some nasty rash from either one of them.

The doctor could also start you on Ziagen ( along with other meds) and you may have an allergic reaction. In which case it needs to be stopped and never used again.

So, what I am trying to say, it's very difficult to answer your question. You won't know until you start.

My post might be upsetting you, and I don't mean for that, but I want to be honest with you. These are all very powerful drugs !! The main thing is to get started, when it's time, and be adherent to them.


Take care----Ray
Current Meds ; Viramune, Epzicom, 40mg of simvastatin, 12.5mg of Hydrochlorothiazide.
Metoprolol tartrate 25mg



http://forums.poz.com/index.php?topic=40802.0

http://forums.poz.com/index.php?topic=45159.0

http://forums.poz.com/index.php?topic=39722.msg495621;topicseen#msg495621

http://forums.poz.com/index.php?topic=46806.0

http://forums.poz.com/index.php?topic=39414.msg491701#msg491701


 In October of 2003, My t-cell count was 16, Viral load was over 500,000, Percentage at that time was 5%. I started my first  HAART regimen  on October 24th,03.

 As of 6/4/14,  t-cells are at 423, Viral load <40

 Current % is at 13% 

  
 62 years young.

Offline Dachshund

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Re: Any drug combinations that work with less side effects?
« Reply #13 on: April 10, 2008, 09:43:44 AM »
It took me three tries in the past five years to find a regimen that worked for me. Two years on Sustiva (Atripla) before I had to change because of side effects. I tolerated it as long as I could because of my good numbers, but eventually changed to Kaletra. Kaletra was the worst because I basically became a poop factory and left the house only to go to work. I put up with that for a couple of years, again because of stellar numbers. This past year I finally reached the promised land of AIDS meds when I made the switch to Prezista. Pretty much side effect free and I couldn't be happier. Unfortunately, Prezista is not considered a frontline drug and you kinda got to jump through hoops to get it. When they said jump, I said, "how high?"

Offline sharkdiver

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  • Posts: 1,350
Re: Any drug combinations that work with less side effects?
« Reply #14 on: April 10, 2008, 11:30:00 AM »
I'm sorry, I was just trying to help. My point was that regiments vary by individual. I have hardly done something like recomendin one pill or the other.

Newer medication do have less side effects than those used in the 1990s. I did not refer to very new stuff like the chemokine receptor CCR5  entry inhibitor.


Perhaps a year is not a good timeframe to be "doling out advice" but I have voluteered in the hiv world for much longer than that.

This is my last message and I'll be leaving the forum now: jg1962 and Bettytacy please take my apologies for my unacceptable behaviour.

So long,

f.

They do have a forum called  Someone I Care about Has HIV,  you might feel more comfortable discussing things there

Sharkie

Offline naftalim

  • Member
  • Posts: 102
Re: Any drug combinations that work with less side effects?
« Reply #15 on: April 11, 2008, 12:07:27 AM »
See if there is a study you can enter into. I'm glad I did. Been almost 3 years now. When I was presented with the option of joining the study, my thinking was as follows:

  • I assume that they are trying to come up with something better than what is out there.
    I will be closely monitored, more so than if I was not in a study
    I have to take meds anyways, I might as well take part in something that may prove beneficial to others.

A few positive things about a study at least here in Canada. The meds are free. They monitor me closely. Initially I was seeing my doctor every 2 weeks, now its every 3 months.

I am on  Selzentry (maraviroc) by Pfizer. At the time I entered the study, it was for treatment naive people, that is people who had not taken meds before. I have had no problems at all. I also take Truvada with it.
It is a twice a day regimen. Now, it is a blind study, but I am fairly certain that I am getting the  Selzentry

Offline tag_man08

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  • Keep Dreaming!!!
Re: Any drug combinations that work with less side effects?
« Reply #16 on: April 13, 2008, 11:04:08 AM »
Thank you for the information everyone.  It was very helpful for me right now.
08/30/07:  The HIV diagnosis...
09/07/07:  CD4 299 (21%)  VL 160K
01/07/08:  CD4 396 (26%)  VL 125K
04/21/08:  CD4 478 (25%)  VL 92K
09/03/08:  CD4 313 (23%)  VL 10K
11/03/08:  CD4 338 (23%)  VL 30K
11/21/08:  Isentress & Truvada
12/05/08:  CD4 485 (29%)  VL  undetectable in two weeks
03/13/09:  CD4 575 (30%)  VL  undetectable

Offline mimi1965

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  • Posts: 12
Re: Any drug combinations that work with less side effects?
« Reply #17 on: April 14, 2008, 01:50:20 PM »
:D Hey There!!  You asked about any combo meds with minimal side effects...I am taking Atripla which I take at bedtime...you take it on a empty stomach and being that it is taken at bedtime you can tolerate better...the first week and only that week I had nausea...that was it!!  You also have weird dreams but that is the most that I have had.....it had done wonders for me...I started on the meds in November of 2007 and my viral load was 100,000 by February it was at 10,000 on y cd4 my count was very low my last cd4 was 285 as compared to below 50 in November, so you see the meds did fine for me and I love the fact that I only have to take 1 pill a day....the thing you must do is to take your meds on time the same time everyday...I have a alarm that goes off on my cell phone to let me know it is time to take my meds...without fail...I hope this has helped ypu...much love,health and happiness........Always, Mimi :D
Always, Mimi

Offline littlefire

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  • Posts: 36
Re: Any drug combinations that work with less side effects?
« Reply #18 on: April 18, 2008, 11:24:02 AM »
Your doctor will be able to tell you what will probably work best for you. I've been on Truvada/Stocrin for 9 months now, and have no side effects except for the fact that I can't eat fermented meats (huge stomache problems with that). But I can live with that, I never liked those things much anyway :) It did take me a few months to figure out what was causing the problem though. And it reiterates the fact that diet, for a person with HIV, is really important.

 


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