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Author Topic: Drug Failure  (Read 1623 times)

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Offline berlin1926

  • Member
  • Posts: 4
Drug Failure
« on: August 16, 2007, 07:43:31 PM »
I started Atripla in early June and am waiting for my first test results since starts meds (yep, I'm a virgin).  Is it possible that I'll find out it isn't working even though earlier tests didn't show any resistance?  Part of the question has to do with how I'm feeling...My CD4's were pretty low when I finally started meds (280 or so) and VL was <100K.  I believe I was infected in 1996.   Do others who have been on meds for a while actually notice that they "feel" better - more energy, cuts heal quicker, etc.. ?

Thanks and warmest wishes to all!

Offline Matty the Damned

  • Member
  • Posts: 12,160
Re: Drug Failure
« Reply #1 on: August 16, 2007, 07:46:37 PM »
Hey Berlin!

You might want to read our lesson on treatment resistance for specific information. There are a couple of ways of testing for resistance and it might be an idea to ask your doctor which one s/he ordered.

MtD

Offline LPinUK

  • Member
  • Posts: 58
Re: Drug Failure
« Reply #2 on: August 16, 2007, 07:57:22 PM »
Hi Berlin.

I take the same medication as you (although not in the combined pill form) and that combo has worked wonders for me, I'm still getting great numbers 2 and a half years after starting.

As matty has already said, take some time to read the lessons, you will find a lot of answers in there.

Most importantly, try not to stress yourself out about this (easier said than done I know), Im sure you will be fine on that combo!

Laurence
Diagnosed Poz September 2003, Current Regimen Truvada & Sustiva.

Offline red_Dragon888

  • Member
  • Posts: 2,803
  • Love and Be Love in Return
Re: Drug Failure
« Reply #3 on: August 16, 2007, 07:58:42 PM »
my numbers was like yours and i was infected in 1986.  anyway the meds are working an my cd4 is around 400 and vl is 50.
http://www.youtube.com/watch?feature=player_embedded&v=I3ba3lnFHik

“Neither look forward where there is doubt nor backward where there is regret. Look inward and ask not if there is anything o

Offline mike2002

  • Member
  • Posts: 15
Re: Drug Failure
« Reply #4 on: August 16, 2007, 08:04:07 PM »
 Do others who have been on meds for a while actually notice that they "feel" better - more energy, cuts heal quicker, etc.. ?

I could not agree more.  One month ago I felt that same burst of energy, everything was better.  Bad news it only lasted a few weeks then I got used to the new found energy, so now I consider it just normal again.

Mike
05/11/06 Initial Diagnosis
05/21/07 CD4 424 / 24,627 Viral Load
06/01/07 Started meds (Kaletra / Atripla)
06/28/07 CD4 542 / 424 Viral Load
08/01/07 CD4 542 / >50

Offline berlin1926

  • Member
  • Posts: 4
Re: Drug Failure
« Reply #5 on: August 16, 2007, 08:09:21 PM »
THANK you everyone who's responded so quickly!  I don't feel so alone!!!

Offline Matty the Damned

  • Member
  • Posts: 12,160
Re: Drug Failure
« Reply #6 on: August 16, 2007, 08:26:24 PM »
Berlin,

If it's any comfort the likelihood of your treatment failing at this point is quite low. Even though you've been positive and treatment naive for a long time, that doesn't mean you won't respond well to medication.

I'm sure you'll be reporting excellent results to us very soon.

Fondly,

MtD

Offline David_CA

  • Member
  • Posts: 3,232
  • Joined: March 2006
Re: Drug Failure
« Reply #7 on: August 16, 2007, 09:35:20 PM »
My numbers were similar to yours when I started Atripla back in December '06.  I was probably infected sometime around 2003 or so.  My numbers are slowly improving, as you can see below and show no resistance.

I do feel lots better since starting meds, but I had PCP at least a couple of months prior and had no energy, etc.  I also find I heal much quicker, don't have as many skin issues, etc.

I'll be curious to see how your numbers are and if you're improving quicker that mine.  I was getting stressed about it, but if I'm improving and feel good, that's what's important.  Take care.

David
Black Friday 03-03-2006
03-23-06 CD4 359 @27.4% VL 75,938
06-01-06 CD4 462 @24.3% VL > 100,000
08-15-06 CD4 388 @22.8% VL >  "
10-21-06 CD4 285 @21.9% VL >  "
  Atripla started 12-01-2006
01-08-07 CD4 429 @26.8% VL 1872!
05-08-07 CD4 478 @28.1% VL 740
08-03-07 CD4 509 @31.8% VL 370
11-06-07 CD4 570 @30.0% VL 140
02-21-08 CD4 648 @32.4% VL 600
05-19-08 CD4 695 @33.1% VL < 48 undetectable!
08-21-08 CD4 725 @34.5%
11-11-08 CD4 672 @39.5%
02-11-09 CD4 773 @36.8%
05-11-09 CD4 615 @36.2%
08-19-09 CD4 770 @38.5%
11-19-09 CD4 944 @33.7%
02-17-10 CD4 678 @39.9%  
06-03-10 CD4 768 @34.9%
09-21-10 CD4 685 @40.3%
01-10-11 CD4 908 @36.3%
05-23-11 CD4 846 @36.8% VL 80
02-13-12 CD4 911 @41.4% VL<20
You must be the change you want to see in the world.  Mahatma Gandhi

Offline AustinWesley

  • Member
  • Posts: 815
    • HIV Discussion Group on Myspace!
Re: Drug Failure
« Reply #8 on: August 16, 2007, 11:41:57 PM »
I started Atripla in early June and am waiting for my first test results since starts meds (yep, I'm a virgin).  Is it possible that I'll find out it isn't working even though earlier tests didn't show any resistance?  Part of the question has to do with how I'm feeling...My CD4's were pretty low when I finally started meds (280 or so) and VL was <100K.  I believe I was infected in 1996.   Do others who have been on meds for a while actually notice that they "feel" better - more energy, cuts heal quicker, etc.. ?

Thanks and warmest wishes to all!

Hey Berlin,

I'm also on the same as you only in 2 seperate pills Truvada/Sustiva.   Just had my 5 month check up and waiting for the current numbers.   However, I do feel much improved now.   Cuts are healing normally now.   My energy seems like I feel about 10 years younger and I'm not sleeping all the time or feeling lethargic anymore.

At first I wondered if my meds were working cause nothing seemed to be happening.   

Guess we are both waiting for lab results at the moment, but I have a feeling we're both gona get good news.

Wesley
Diag. 3/06  Infected aprx. 2 mo. Prior
Date        CD4   %      VL
4/6/06     627    32    36,500     NO MEDS YET!
6/7/06     409    27    36,100
8/23/06   408    25     22,300
1/2/07     354    23     28,700
2/9/07     139    30     23,000  Hep A Vaccine same day???
2/21/07   274    26     18,500 
3/3/07    RX of Truvada/Sustiva Started.
4/5/07    321     27      Undectable 1st mo.  
5/16/07  383     28    Undectable 2nd mo.
8/10/07  422     32   UD <48 on new scale!

Offline gaz41

  • Member
  • Posts: 54
Re: Drug Failure
« Reply #9 on: August 18, 2007, 12:47:04 PM »
I started on a different combi and felt like shit for the first 6 months and thought the same that perhaps it wasn´t working but my numbers were steadily improving and when i changed my combi after a year as the side effects hadn´t eased and i had given it a good enough go i strted to feel better immediately for last 3 years ihave been taking truvada and viramune and am doing fine

 


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