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Poll

What side effects can one expect the first few weeks having never taken HIV neds before?

New to this so I do not know what to put here.
0 (0%)
Please inform me what options are about?
0 (0%)

Total Members Voted: 0

Voting closed: March 21, 2008, 01:09:35 PM

Author Topic: Lexiva and Truvada- First regimen  (Read 3083 times)

0 Members and 1 Guest are viewing this topic.

Offline gr8tguyoc

  • member
  • Posts: 2
Lexiva and Truvada- First regimen
« on: February 20, 2008, 12:09:35 PM »
I found out I was HIV positive in August of 2007 after becoming quite ill with flu like symptoms. My HIV specialist is an advocate of "earlier is better" so after having labs completed three times my CD4 is now at 440 and my viral load is at 28% or 16200 copies. My first labs were - CD4 - 590 and viral load was 31% or 15600 copies. My doctor classified my disease is "simmering" at this time however it continues to lower my CD4 count as the disease progresses. I have decided to go on meds however I do not wish to go on Sustiva therefore I will not use Atripla due to some of the side effects that are possible when taking this medication. I understand that everyone is an individual however I feel it is not the drug of choice for me. We have decided to use Lexiva 4 X 700 mg tabs along with Truvada 1 X 200 mg. I work in the field and drive allot so I did not want to go on a medication that will cause diarrhea to cause frequent bathroom stops.

What side effects has anyone had from taking this regimen and for what duration? I have read the possible side effects directly from the drug manufacture but those are all possible side effects so i am curious about what the community here has to offer. I am a new member and look forward to learning all I can from these polls/blogs.

Alex

Offline BT65

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  • Posts: 9,979
Re: Lexiva and Truvada- First regimen
« Reply #1 on: February 20, 2008, 12:24:56 PM »
Hi Alex, and welcome to the forums. :)

I was on that combination a few years back and had virtually no side effects from it.  However, I grew resistant to both (Lexiva, Truvada).

In the upper left of your screen is the Aidsmeds.com logo.  Under there is a link 'Drugs' you can click on to help you sort through this.  I'm sure others will chime in with what they've experienced as well. 

Again, welcome.  Look forward to hearing more from you.
I've never killed anyone, but I frequently get satisfaction reading the obituary notices.-Clarence Darrow

Offline gr8tguyoc

  • member
  • Posts: 2
Re: Lexiva and Truvada- First regimen
« Reply #2 on: February 21, 2008, 01:42:20 AM »
Thanks for your reply, so far I am resistant to nothing as that i what my Geno type test revealed . I guess time will tell.

Offline aztecan

  • Member
  • Posts: 5,400
  • 29 years positive, 57 years a pain in the butt
Re: Lexiva and Truvada- First regimen
« Reply #3 on: February 21, 2008, 11:19:33 PM »
Hey Alex,

I've been on Lexiva/Norvir for four months or so at the moment. I've had no side effects from it whatever.

However, prior to Lexiva, I was on Reyataz/Norvir for a few months and prior to that, Sustiva, which was a nightmare for me - literally.

Before that, I spent 11 years on Crixivan, which is a med most docs don't prescribe much these days, but it works great if you can stick with it.

I've never been on Truvada. I have been on Combivir or its components, AZT and Epivir (3TC) for nearly 12 years now.

When I first began, I was taking Saquinavir (Invirase) in its original formulation and had severe gastrointestinal problems. Let's talk enough gas to float the Hindenberg and projectile diarrhea that, if aimed properly, could take out a neighbor 50 feet away.

That was why I switched to Crixivan in short order. There weren't many PIs available at the time.

The intestinal difficulties continued, but to a much lesser degree. They finally subsided for the most part in six or seven weeks, if memory serves.

I used to get nausea every time I took my meds, but that was because they had to be taken on an empty stomach exactly eight hours apart. (Did I mention Crixivan was a pain at times.)

I think all of us still get the hersheys once in a while, some more than others. It just seems to be part of living with this stuff.

Remember not everyone will get side effects and the degree to which they bother you also varies between individuals.

Hang in there and let us know how things go.

HUGS,

Mark
« Last Edit: February 21, 2008, 11:31:48 PM by aztecan »
"May your life preach more loudly than your lips."
~ William Ellery Channing (Unitarian Minister)

Offline Ann

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  • Posts: 28,140
  • It just is, OK?
    • Num is sum qui mentiar tibi?
Re: Lexiva and Truvada- First regimen
« Reply #4 on: February 22, 2008, 06:51:55 AM »
Hi Mark,

Could you please elaborate on why you stopped the Reyataz/Norvir component and switched to Lexiva/Norvir? I ask because there's a good chance I'll be on meds before the end of the year and I'm looking at combining Reyataz/Norvir with Truvada. (I want to avoid Sustiva if I can) I've also looked at Lexiva/Norvir, so this is why I'm wondering why you switched.

Thanks in advance...

Ann
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Offline ARMANDO

  • Member
  • Posts: 251
Re: Lexiva and Truvada- First regimen
« Reply #5 on: February 22, 2008, 08:27:37 AM »
i am presently on lexiva and truvada along with norvir boost and the side effects have been somewhat tolerable.the one side  effect that bothers me the most is the skin reaction(itchy rashes all over the body. having constant gas and bloating is not quite flattering also but i can deal with that!!this is the first regiment in 15 yrs that has lead me to be UNDECTECTABLE

Offline ubotts

  • Member
  • Posts: 347
Re: Lexiva and Truvada- First regimen
« Reply #6 on: February 22, 2008, 10:53:00 AM »
Hi there.
I am on the same meds..but they also added in Noviar...I have had no side effects from
any of these meds..
Everyone is different, but its not bad at all so dont worry unless you have to.. ;)
Live Love Laugh and dance like no ones watching.
Laughter is the best medicine, so try to have a laugh everyday..Even if your not feeling your best, think about something that was funny at one time in your life and work with it..   :o)

Offline ubotts

  • Member
  • Posts: 347
Re: Lexiva and Truvada- First regimen
« Reply #7 on: February 22, 2008, 11:00:18 AM »
Hi Mark,

Could you please elaborate on why you stopped the Reyataz/Norvir component and switched to Lexiva/Norvir? I ask because there's a good chance I'll be on meds before the end of the year and I'm looking at combining Reyataz/Norvir with Truvada. (I want to avoid Sustiva if I can) I've also looked at Lexiva/Norvir, so this is why I'm wondering why you switched.

Thanks in advance...

Ann
xxx

Dear Ann, I would be considering a different medicine then reyataz..I was on that for 3 weeks and had bad acid reflux...So they changed my regimen from reyataz to Lexiva...
Truvada is great, no problems at all in fact it has no azt in it..so thats good,and i also take Noviar.
It was a piece of cake for me...Hope that doesnt happen to you..But it did to quite a few in this forum..
Good luck in whatever you chose.... :-\
Live Love Laugh and dance like no ones watching.
Laughter is the best medicine, so try to have a laugh everyday..Even if your not feeling your best, think about something that was funny at one time in your life and work with it..   :o)

Offline aztecan

  • Member
  • Posts: 5,400
  • 29 years positive, 57 years a pain in the butt
Re: Lexiva and Truvada- First regimen
« Reply #8 on: February 24, 2008, 12:55:06 AM »
Hey Ann,

Sorry this took so long. I switched from Reyataz/Norvir because I have a long history of acid reflux problems and, prior to taking Reyataz, was taking Protonix, which is in the same family of meds as Prilosec, Nexium, which are proton pump inhibitors and reduce the amount of acid your stomach secretes.

Unfortunately, Reyataz requires stomch acid to be absorbed properly, so I had to stop taking the PPI (proton pump inhibitor) This didn't set well with my stomach and antacids were only marginally effective.

So, I had to switch, in this case to Lexiva.

I should say that, aside from my PPI issues, Reyataz was a wonderful drug.  I had no side effects from it at all. It is once a day dosing, so it is very easy to live with and the Norvir used to boost it is such as low level I suffered no side effects from it either.

As far as Lexiva goes, it is a twice a day regimen, and requires 100 mgs of Norvir be taken with it morning and evening.

That said, I also have had no side effects from it either. For me, it has been a godsend because my poor stomach needs its Protonix.

I think you probably remember my problems with Sustiva, so no need to delve into those again unless you want to for some reason.

I don't recall you mentioning any stomach issues or acid reflux problems. If those are absent, which I hope they are cause they're a pain, I would probably opt for the Reyataz, just for the ease of the regimen. Once a day is a great deal if you can get away with it.

If memory serves, Jan started on the Reyataz/Norvir/Truvada (or its equivalents). She reported she did turn yellow for a bit, which Reyataz can do, but it isn't dangerous. I think she had some other initial side effects, but I don't know if they are still a problem for her.

Maybe she will respond to this as well.

I hope this answers your concerns regarding the Reyataz and Lexiva regimens. I know the prospect of meds hasn't always excited you.

HUGS,

Mark
"May your life preach more loudly than your lips."
~ William Ellery Channing (Unitarian Minister)

Offline ubotts

  • Member
  • Posts: 347
Re: Lexiva and Truvada- First regimen
« Reply #9 on: February 24, 2008, 11:12:47 AM »
Hi Newbie..
I am on those two meds that you will begin.
I experinced no side effects at all, but then again, I have been on meds for 8 yrs...
Some had side effects and some didnt..

Everyone's body is different, so all I can offer you is that I felt no side effect at all from
Lexiva and Truvada...........I am also on Noviar, and thats been ok with me as well..

Hope you have a smooth ride with the meds... :)
Live Love Laugh and dance like no ones watching.
Laughter is the best medicine, so try to have a laugh everyday..Even if your not feeling your best, think about something that was funny at one time in your life and work with it..   :o)

Offline LiveWithIt

  • Member
  • Posts: 395
Re: Lexiva and Truvada- First regimen
« Reply #10 on: March 12, 2008, 11:25:35 AM »
I am on Lexiva, Truvada and Norvir.  I take it once a day at night.  I have been on it for a long time.  My best friend is Imodium or the generic version.  That may be to a poor eating habits. 

I have been on these Meds for over a year and am nearly undetectable.
Pray God you can cope
I know you have a little life in you yet.
I know you have a lot of strength left.

Offline BassMan

  • Member
  • Posts: 77
  • Gran Canaria 2006
Re: Lexiva and Truvada- First regimen
« Reply #11 on: March 19, 2008, 07:53:32 AM »
I have been on Lexiva (Telzir as it's known here in the UK, or to give it it's Sunday name, fosamprenavir) plus Truvada since September 2005 and have been undetectable since November 2005. I switched from Reyataz to Lexiva because I have a polymorphism that makes me very slightly resistant to Reyataz, which meant I couldn't quite get to undetectable on it.

Neither regimen caused me any significant side effects apart from occasional "looseness" about an hour after taking it. Reducing the Norvir from 200mg to 100mg has pretty much eliminated this for me. I now take 2 x 700mg Lexiva with 1 x  100mg Norvir booster, plus one Truvada, daily in the mornings, and have had great results from it.

It's worth mentioning that you can take Lexiva once daily if you're PI naive and that the FDA recently approved it for use with only 100mg Norvir. It's not actually licensed to be prescribed that way in the UK, but many doctors including mine will do so, although they might want to do initial TDM (therapeutic drug monitoring) for the first few weeks to ensure you're absorbing adequate levels of the drugs into your blood.

Hope this helps.

Carl,
Manchester, UK
« Last Edit: March 19, 2008, 07:56:36 AM by BassMan »
Diagnosed December 2002
CD4 810 VL 750,000

Started meds October 2004
CD4 405 VL >100,000

Latest Results: October 2009
CD4 888 38%, VL undetectable
on fosamprenavir/ritonavir & Truvada

VL undetectable since November 2005

 


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