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Author Topic: Possible new uk treatment guidelines  (Read 1219 times)

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Offline NLEWLAD

  • Member
  • Posts: 230
  • Anything is possible, ANYTHING
Possible new uk treatment guidelines
« on: March 03, 2008, 03:38:23 PM »
Today i have been to see my doc for treatment for syphillis, was given 28 days supply of vibrox   

i then asked her what her feelings for starting treatment early  and would the nhs fund early treatment

it was a simple answer i will recomend treatment when your CD4 drops below 450-500 as new research has found that starting treatment early is beneficial

Aparently a report is due to come out in the uk to support this new finding
Simon - Location Manchester England
Negative test 10/11/07
Tested poz 28/12/07
Confirmed WB 07/01/08
Sero-converted Late December 07

Date        CD4            %              VL

7/01/08   1273 :)      N/A       100,232
24/01/08   755 :(      42%         4,010
13/2/08     922 :)      45%       78,234
09/04/08   652 :(      38%       36,604
05/05/08   936 :)      39%       38,952
07/07/08   844 :)      34%       24,000
12/11/08   753 :(      31%       45,600
no meds yet:)

Offline newt

  • Member
  • Posts: 3,885
  • the one and original newt
Re: Possible new uk treatment guidelines
« Reply #1 on: March 03, 2008, 04:41:25 PM »
Yes and no

There has been much recent data showing less illness and death among people treated with CD4 of 350+ compared to 201-350, and some looking at 350 v 500 as a cut-off point. 

I believe the argument on "treat at 350"  is won and will be reflected in the next set of UK guidelines due out this Spring. 

As for "treat at 500"? Dunno, more arguable, merit in both sides of the argument.  However, doctors are entitled to draw their own conclusions, many docs in the UK are well read and the data supports a recommendation to treat at 500 or thereabouts if you want to read it that way.

One useful link perhaps (kinda technical)

Start treatment at 500 or 350? UK cohort data show clear difference in risk of death

- matt
"The object is to be a well patient, not a good patient"

Offline NLEWLAD

  • Member
  • Posts: 230
  • Anything is possible, ANYTHING
Re: Possible new uk treatment guidelines
« Reply #2 on: March 03, 2008, 05:02:39 PM »
its a good read,

i am happy as my doc will now script me meds at my required cd4 level  450  which i am over the moon about

Simon - Location Manchester England
Negative test 10/11/07
Tested poz 28/12/07
Confirmed WB 07/01/08
Sero-converted Late December 07

Date        CD4            %              VL

7/01/08   1273 :)      N/A       100,232
24/01/08   755 :(      42%         4,010
13/2/08     922 :)      45%       78,234
09/04/08   652 :(      38%       36,604
05/05/08   936 :)      39%       38,952
07/07/08   844 :)      34%       24,000
12/11/08   753 :(      31%       45,600
no meds yet:)

Offline komnaes

  • Member
  • Posts: 1,893
Re: Possible new uk treatment guidelines
« Reply #3 on: March 04, 2008, 03:50:00 AM »
Hong Kong still tends to follow UK guidelines. I really wonder if local doctors are going to follow. I am still a bit over 350 so I have another 2-3 months at least until my next blood works to have to face this issue and hopefully I still don't need to bring this up (i.e. if my CD4 still above 350). A friend has been as low as 180 and now at mid 200s, and the Hong Kong doctors are still asking her to wait.
Aug 07 Diagnosed
Oct 07 CD4=446(19%) Feb 08 CD4=421(19%)
Jun 08 CD4=325(22%) Jul 08 CD4=301(18%)
Sep 08 CD4=257/VL=75,000 Oct 08 CD4=347(16%)
Dec 08 CD4=270(16%)
Jan 09 CD4=246(13%)/VL=10,000
Feb 09 CD4=233(15%)/VL=13,000
Started meds Sustiva/Epzicom
May 09 CD4=333(24%)/VL=650
Aug 09 CD4=346(24%)/VL=UD
Nov 09 CD4=437(26%)/VL=UD
Feb 10 CD4=471(31%)/VL=UD
June 10 CD4=517 (28%)/VL=UD
Sept 10 CD4=687 (31%)/VL=UD
Jan 11 CD4=557 (30%)/VL=UD
April 11 CD4=569 (32%)/VL=UD
Switched to Epizcom, Reyataz and Norvir
(Interrupted for 2 months with only Epizcom & Reyataz)
July 11 CD=520 (28%)/VL=UD
Oct 11 CD=771 (31%)/VL=UD(<30)
April 12 CD=609 (28%)/VL=UD(<20)
Aug 12 CD=657 (29%)/VL=UD(<20)
Dec 12 CD=532 (31%)/VL=UD(<20)
May 13 CD=567 (31%)/VL=UD(<20)
Jan 14 CD=521 (21%)/VL=UD(<50)

 


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