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Author Topic: Meds that combine with Isentress?  (Read 1960 times)

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Offline bkc

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  • Posts: 1
Meds that combine with Isentress?
« on: February 04, 2008, 05:04:33 PM »
My doc recently started me on a cocktail of Atripla and Isentress after many years on a different group of drugs.  The Sustiva in the Atripla is doing strange things to my mind and I don't think I can continue it much longer.   I know Isentress is not a standalone drug. 

Does anyone one have any idea what other HIV meds or classificatiion of meds are generally subscribed with the Isentress?  I have been unable to find this information online, but would like to be more prepared when I vidit my doctor again. 

Offline newt

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Re: Meds that combine with Isentress?
« Reply #1 on: February 04, 2008, 05:15:46 PM »
Given that it's a new drug, as far as is known, Isentress can be combined with all anti-HIV drugs except Aptivus

- matt
"The object is to be a well patient, not a good patient"

Offline Miss Philicia

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Re: Meds that combine with Isentress?
« Reply #2 on: February 04, 2008, 05:25:58 PM »
I'm on Prezista (w/ Norvir booster) and Truvada with Isentress.  I have no side effects from this combo, except a small amount of infrequent gas which I assume is from Truvada.  Overall it's the most highly tolerable combo I've taken in 15 years of treatment.
"Iíve slept with enough men to know that Iím not gay"

Offline freestate guy

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Re: Meds that combine with Isentress?
« Reply #3 on: February 04, 2008, 11:23:49 PM »
I am combining Isentress with Truvada. No known problems after six weeks.
Mitochondriac

Offline paintkansas40

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  • Posts: 3
Re: Meds that combine with Isentress?
« Reply #4 on: February 07, 2008, 04:00:32 AM »
Why not Aptivus? I am now on both [Isentress & Aptivus] Thanks

Offline newt

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Re: Meds that combine with Isentress?
« Reply #5 on: February 07, 2008, 04:41:38 AM »
A small study found Isentress (MK-0518) levels were reduced when combined with boosted Aptivus (tipranavir/ritonavir).

Total exposure to Isentress was reduced by 26% and the end of dose level of this drug was reduced by 55%. (ref: Wenning LA, Hanley H, Stone J, et al. Effect of tipranavir + ritonavir on pharmacokinetics of MK-0518. 46th ICAAC. September 27-30, 2006, San Francisco. Abstract A-374.)

This wont be important for everyone.  Even with the reduction, the Aptivus will be at an effective level for many/most people. 

The proof, of course, is in the viral load result.

But, for choosing a combination in a second-line/"salvage" situation, perhaps worth noting the limited interaction data and considering other easier to combine drugs first (if available to use).

- matt
"The object is to be a well patient, not a good patient"

Offline paintkansas40

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  • Posts: 3
Re: Meds that combine with Isentress?
« Reply #6 on: February 07, 2008, 06:43:32 PM »
Thanks Matt. True, we'll see what happens with the VL, less than 50 now. Taking a break from fuzeon, just started Isentress. 

 


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