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Author Topic: changing meds  (Read 1798 times)

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Offline countryfan

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  • Posts: 4
changing meds
« on: January 22, 2008, 09:06:11 AM »
I've been pos for 9 years.  Initial counts were 423 viral load (not thousands - just 423) but T cell was 398.  Immediately went undetectable.  Put on Fortavase, Combivir, Norvir.  Soon switched to just Fortavase 8 bid, combivir 1 bid.  over time decreased to just 1 fortavase bid and 1 combivir bid.  Been up in 700 - 900 T cell the whole time.  No one can explain to me why numbers were odd to begin with.  Also now that fortavase is off market my doc wants to switch me to Invirase, Combivir and Norvir.  My question:  Why was I able to take such a low dose of the first cocktail?  Can I do the equivalent of Invirase without the norvir booster? What about going off meds all together and just monitor?  Thanks for any imput.  My doc just isnt interested in anyone that takes interest in their own health.

Offline aztecan

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  • Posts: 5,512
  • 31 years positive, 59 years a pain in the butt
Re: changing meds
« Reply #1 on: January 22, 2008, 11:02:33 AM »
Hey Countryfan,

Welcome to the forums.

You probably were able to get by with such a low dosage because you had a very low viral load and a strain that was very sensitive to your meds, although that is just a guess.

As for the Invirase, it is always boosted with Norvir these days. It was one of the first PIs approved. I used to take it without the Norvir boost back in 1996 and, I can say without equivocation, it sucked. In my case, the side effects were so nasty I had to switch to Crixivan.

These days, with lower doses of Invirase boosted with a low-dose Norvir, people seem to do very well with it.

Why is your doc recommending such an old regimen? Most docs these days would be recommending Kaletra or Reyataz, the latter with a 100 mg Norvir boost.

Just curious. Invirase is a good drug, just not as commonly used these days.

Edited to add: OK, call me dense. Its early. Anyway, Fortovase was another form of Saquinavir (Invirase). Which is probably why your doc is doing what he's doing. Invirase still must be boosted though.

The only time people can get away with not boosting the PIs these days is when they are treatment naive, which you're not.

Low dose Norvir doesn't cause the same problems as full dose Norvir, though, so it really shouldn't be a problem.


« Last Edit: January 22, 2008, 11:14:43 AM by aztecan »
"May your life preach more loudly than your lips."
~ William Ellery Channing (Unitarian Minister)


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