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Author Topic: Maravioc / Fuzeon Difference  (Read 1082 times)

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Offline David84

  • Member
  • Posts: 34
Maravioc / Fuzeon Difference
« on: January 09, 2008, 10:51:15 PM »
I'm a bit confused and would like some input on this subject. Saw my doc today. My Trofile results came back as dual so therefore am not eligible for Maravioc. I have been on Fuzeon since 2003.. and getting tired of being a pincushion. Anyhow, the question is if both drugs are in the entry inhibitor class, would the fact that I have dual receptors cause Fuzeon to be ineffective? Still waiting for phenotype to come back.. should be another week or so. This is all stemming from the fact that in Dec. my cd4 took a nosedive to 35 and vl up to 145000. Current drugs- Prezista, Norvir, Truvada and Fuzeon.  Reltegravir and Etravirine are in the que pending phenotype results.  You'd think after 24 years of living with all this I wouldn't be so confused.. but alas, I am.

Many thanks.
David

Offline trellium

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  • stArk raving Borg
Re: Maravioc / Fuzeon Difference
« Reply #1 on: January 10, 2008, 05:52:44 AM »
Hi David,
 
the "entry inhibitor" term is broadly used but each drug targets a different protein in the entry process.
 
Fuzeon targets the gp41 protein on HIV whereas Maraviroc targets the CCR5 protein on the CD4 cells.
The dual/mixed tropism assay result means that the virus is using CCR5 and CXCR4 receptors when binding with CD4 cells, and that pretty much ruled out the use of Maraviroc.

Having a dual/mixed tropic virus is not a factor to developing resistance to Fuzeon as it (Fuzeon) has a low genetic barrier to resistance.

What are Entry Inhibitors (including Fusion Inhibitors)?
http://www.aidsmeds.com/archive/EIs_1627.shtml

Resistance to Enfuvirtide Does Not Affect Susceptibility to Other Classes of Entry Inhibitors
http://www.hivandhepatitis.com/recent/2007/020907_d.html

 


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