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Author Topic: The NEW pill  (Read 7191 times)

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Offline krakerjm

  • Member
  • Posts: 107
The NEW pill
« on: July 13, 2006, 03:35:18 PM »
The one pill once a day durg announced:  interesting but probaly not the right combo for everyone; but it's a start.  As paients run out and genrics are on the horizen the pharma companies have to do something to get our money.  Genric HIV drugs will come in most of our life times so the pharma companies have to stay on top of it: how 'bout a cure instead?!?
GWM, 63, PN w/footdrop
"I swear there ain't no heaven, pray ther ain't no hell"

Offline getbusyliving

  • Member
  • Posts: 32
Re: The NEW pill
« Reply #1 on: July 13, 2006, 06:13:10 PM »
now down to one a day.  next stop - none a day.  it will happen!
I decided it was either time to get busy living or get busy dying.

120304 diagnosed cd4 26 vl 30,000.
012305 started meds - Reyataz, Norvir, Truvada
06xx05 simply undetectable
07xx06 cd4 202 vl 94
0507 cd4 198 vl undetectable
today - feeling strong

Offline jupiter

  • Member
  • Posts: 89
Re: The NEW pill
« Reply #2 on: July 13, 2006, 10:57:22 PM »
now down to one a day.  next stop - none a day.  it will happen!


I BELIVE IT!!

The cure will come. Ther is so much competition for it.

Offline HIVworker

  • Member
  • Posts: 918
  • HIV researcher
Re: The NEW pill
« Reply #3 on: July 13, 2006, 11:57:01 PM »
All of the big pharma companies I know are working on a cure. The most visible thing they can do is improve therapy now. These sorts of things are what you can expect in the short term as well as drugs with better resistance profiles. A cure takes time, so this will do for now but is not the final word - trust me.

R
NB. Any advice about HIV is given in addition to your own medical advice and not intended to replace it. You should never make clinical decisions based on what anyone says on the internet but rather check with your ID doctor first. Discussions from the internet are just that - Discussions. They may give you food for thought, but they should not direct you to do anything but fuel discussion.

Offline randym431

  • Member
  • Posts: 1,125
Re: The NEW pill
« Reply #4 on: July 14, 2006, 12:06:45 AM »
I'd be VERY happy with a ONCE A WEEK pill(s). Or, twice a week.

Offline mike

  • Member
  • Posts: 30
Re: The NEW pill
« Reply #5 on: July 14, 2006, 06:07:30 PM »

I BELIVE IT!!

The cure will come. There is so much competition for it.

Not wanting to be a wet blanket but that's what they told me about diabetes when i was first diagnosed at the age of ten, 1975 i believe it was  ;)

This disease has now shifted territory from death sentence to chronic illness putting it in the same league as diabetes in terms of conditions of life ( not effects) but let's not kid ourselves, it's the smartest most insidious virus ever to hit us as a race, it lives, it breathes, it learns and it mutates and resists.

I look to the future with optimism and hope but personally, i think a cure is way out of our reach in this lifetime, hell, we can't even isolate the virus yet to analise it.

I can only stress again, for me that is not being negative, just my opinion, we are here and we are going to stay here and that is reason enough for me to be optimistic.

As for the pill burden, i can't feel the same way as some of you because for me, after 30 years of injecting insulin 3 or 4 times a day, a few pills is a walk in the park ( without wanting to sound too dramatic or self-pitying cos i never had a problem with jabbing myself anyway ) ;)
« Last Edit: July 14, 2006, 06:10:18 PM by mike »

Offline jordan

  • Member
  • Posts: 239
  • What I want is a celebration
Re: The NEW pill
« Reply #6 on: July 14, 2006, 06:22:04 PM »
The one pill once a day durg announced:  interesting but probaly not the right combo for everyone; but it's a start.

It is very exciting news.....I'm happy that I choose Truvada to go with the Sustiva

My doctor recommended the Sustiva and then gave me a couple of options to go with the Sustiva

I just wonder if I had chosen another pill if I would have been able to switch to Atripla.


« Last Edit: July 14, 2006, 06:55:20 PM by jordan »
If you think your lonely now, wait until tonight.

Offline cubbybear

  • Member
  • Posts: 510
  • Joined August 2005.
Re: The NEW pill
« Reply #7 on: July 14, 2006, 08:24:48 PM »
Yeah im another Truvada/Sustiva pill popper who'll change to Atripla when it's available in Australia. 

I believe they'll cure this bitch though.. oneday... or at least find a breakthrough in treatment unlike HAART.
There's a bear in there!
Positive since 2000
Diagnosed 17/9/2005 CD4 35 VL 293,000
Meds 23/9/2005 Sustiva/Truvada
Currently CD4 232 VL Undetectable

Offline appleboy

  • Member
  • Posts: 344
  • Just me!
Re: The NEW pill
« Reply #8 on: July 14, 2006, 08:29:55 PM »
yes it is exciting for us that are on the Sustiva Truvada now.  I hope it will maybe allow some that are not on it to possibly move to it.  Side effects aside it works damn well!
AppleBoy
If you are walking down the street and your pants drop to your ankles bend over pick them up and keep on walking!
My Blog

Offline Eldon

  • Member
  • Posts: 2,664
Re: The NEW pill
« Reply #9 on: July 14, 2006, 09:02:02 PM »
I beleive there is a cure on it's way. It has to be.

Offline cubbybear

  • Member
  • Posts: 510
  • Joined August 2005.
Re: The NEW pill
« Reply #10 on: July 14, 2006, 09:08:37 PM »
The new pill isn't the best news though for those people who can't deal with Sustiva's notorious side effects, but Atripla will just be the first of many one pill a day drug regimens I think.
There's a bear in there!
Positive since 2000
Diagnosed 17/9/2005 CD4 35 VL 293,000
Meds 23/9/2005 Sustiva/Truvada
Currently CD4 232 VL Undetectable

Offline otherplaces

  • Member
  • Posts: 398
  • Mutant Super Hero
Re: The NEW pill
« Reply #11 on: July 14, 2006, 10:15:09 PM »

I'm not on meds yet, but I imagine it's coming fast for me. I've followed the news on this combo pill and hoped I could hold out long enough to be able to use it as my first line regimen (barring unforseen resistance on the front end). So I'm pretty happy and feel pretty fortunate that this is probably where I'll begin treatment.

Aside from all that I'd love to sit in the room when they come up the names for these drugs.  ???

"It's a TRIPLE, why don't we call it A TRIPLER!!!"
"No, that's too obvious and doesn't sound sciency enough...how about A TRIP LA???"
"Done! A new age is upon us!!"

brian



Offline appleboy

  • Member
  • Posts: 344
  • Just me!
Re: The NEW pill
« Reply #12 on: July 15, 2006, 12:16:34 AM »
Humm how about Atripya since it seems to make ya dizzy and gives quite the dreams!
 ::)
AppleBoy
If you are walking down the street and your pants drop to your ankles bend over pick them up and keep on walking!
My Blog

Offline otherplaces

  • Member
  • Posts: 398
  • Mutant Super Hero
Re: The NEW pill
« Reply #13 on: July 15, 2006, 01:59:40 AM »

Atripya, stops HIV, better than LSD.

After hearing desriptions of the acid dreams I'm actually kind of looking forward to that side effect.

I've never done acid. In the future I can regail people at parties with my Atripla stories.
"You think that's fucked up...check this shit out doode!!!"

brian

Offline ryeguy

  • Member
  • Posts: 173
Re: The NEW pill
« Reply #14 on: July 15, 2006, 08:36:50 AM »
Just an open question here, does anyone know how the individual components of this new pill are with lipodystrophy. Are any of the single components likely hard on fat???

Offline DCGuy511

  • Member
  • Posts: 61
Re: The NEW pill
« Reply #15 on: July 15, 2006, 12:39:57 PM »
The new pill includes the NRTI Viread. 

"Anti-HIV drug regimens containing NRTIs, including Viread, can cause increased fat levels. . ."
From the Drugs section of AidsMeds.

The virus I have is resistant to the non-nukes, so this new pill is not an option for me.  But, I think that it is fantastic news that a one pill, once-a-day treatment is available.  This will make compliance easier for many people. And with more treatment naive people on this easier regimen, hopefully we'll see less spreading of drug-resistant strains.  One of the most difficult stumbling blocks to treatment has been the very complex drug regimens that we have to manage.

I think that the biggest benefit will be seen in developing countries where the complex, multi-pill regimens have been difficult to use.  It will be a lot easier to widely distribute Atripla, than it was to distribute the three base meds individually.

I like progress.
Steve
Infected/Diagnosed Fall 2003
"No Man Is An Island" - J Donne

Offline MoltenStorm

  • Member
  • Posts: 477
  • Poz & Fabulous
Re: The NEW pill
« Reply #16 on: July 15, 2006, 12:50:27 PM »
I find out my new results on Thursday (July 20th), and if I decide to start meds, I'm definitely going with Atripla (sounds so frenchy).

"Oui, dahling. I went for a stroll in the atrium today, and it was most atripla!"
"Love is always patient and kind. It is never jealous. Love is never boastful nor conceited. It is never rude or selfish. It does not take offense and is not resentful. Love takes no pleasure in other people's sins, but delights in the truth. It is always ready to excuse, to trust, to hope, and to endure whatever comes." - 1 Corinthians 13:4-7, adaptation in A Walk To Remember

CD4: 555 / 29% / Undetectable - 7 Nov 2006
CD4: 555 / 29% / Undetectable - 5 Feb 2007

Offline dario

  • Member
  • Posts: 80
Re: The NEW pill
« Reply #17 on: July 15, 2006, 02:30:31 PM »
A cure takes time, so this will do for now but is not the final word - trust me.

R

R,
I trust you
D
... when I was young, I never needed anyone, making love was just for fun, those days are gone ... Eric Carmen (Raspberries)

Offline sweetasmeli

  • Member
  • Posts: 1,052
  • Love what you are...
Re: The NEW pill
« Reply #18 on: July 15, 2006, 02:45:23 PM »
....hell, we can't even isolate the virus yet to analise it.

Please can someone explain this comment?
I have heard conflicting views on this issue that confuse me, in fact most things to do with science confuse me!
So anyone please, in layman's terms if poss...

Melia
/\___/\       /\__/\
(=' . '=)    (=' . '=)
(,,,_ ,,,)/   (,,,_ ,,,)/ Cats rule!

The difference between cats and dogs is that dogs come when called, whereas cats take a message and get back to you.

Yeia kai hara (health and happiness) to everyone!

Offline jordan

  • Member
  • Posts: 239
  • What I want is a celebration
Re: The NEW pill
« Reply #19 on: July 15, 2006, 04:47:51 PM »
I find out my new results on Thursday (July 20th), and if I decide to start meds, I'm definitely going with Atripla (sounds so frenchy).

I'm not sure about French  ;D....but there is a whole art and science behind these new drug names.  For example, Viagra was named based Niagra (as in Niagra falls and the force it has).

If you think your lonely now, wait until tonight.

Offline allopathicholistic

  • Member
  • Posts: 3,258
Re: The NEW pill
« Reply #20 on: July 15, 2006, 06:14:42 PM »
Melia: I had asked the same question a few months back and if I remember correctly, aztecan (Mark) told me the virus has been isolated. I'm slightly science-challenged myself  ;), so if anyone wants to explain using laymens terms  , please feel free  ;D thanks
« Last Edit: July 15, 2006, 06:26:18 PM by allopathicholistic »

Offline RobT

  • Member
  • Posts: 319
Re: The NEW pill
« Reply #21 on: July 16, 2006, 12:49:03 AM »
I am excited that this once a day pill formula has come out or having big pharma companies pool their resources. It will get better and I remain optimistic that a cure will b found. Both of those take time though.
I am currently still on the Sustiva/Truvada formula. I do not know if/when I will switch. I have the pt of view if something works, then y switch. I guess that will change according to what my doctor says.

RobT

9/27/2005-1st test results
Viral Load >1,000,000
CD4 204
CD4%age 18
CD4/CD8 ratio .23
11/24/2005- Sustiva/Truvada
04/18/2006
Viral Load 140
CD4 402
CD4%age .21
CD4/CD8 ratio .39

06/27/2006
Viral Load 42
CD4 409
CD4%age .21
Next appt.-07/11/2006 (lab)
Next appt.-08/01/2006 (results/Hep A/B vaccination)


Current meds: Atripla
VL: undetectable
CD4: 630

Offline bobik

  • Member
  • Posts: 315
    • My worksite
Re: The NEW pill
« Reply #22 on: July 16, 2006, 09:21:04 AM »
Sometimes I am a bit worried about all that putting more meds in one tablet. Taking less pills seems to be a goal now. I have had trouble twice with trying to take a twice daily tablet once daily: side effects got worse and now I can't even deal with both meds once daily anymore. I think if you feel well on what you got and you are vulnerable to side effects it is wise to keep on using what you got, if you can deal with taking meds twice daily.
Coen Honig at Facebook

Offline ScottSoFla

  • Member
  • Posts: 4
Re: The NEW pill
« Reply #23 on: July 21, 2006, 03:39:16 PM »
Well yesterday I made the decision to start meds and my doctor had suggested I consider Sustiva/Truvada a few weeks ago and do my research. Of course I found out about Atripla and left his office with the first prescription he had written for it. Went to the pharmacy and was the first one to get it as well.

A little worried about side effects but I guess I'm going to have to give it a try and see how it goes. I've opted for a morning dose as I work later nights and eat afterwards close to bedtime and have usually have a couple of beers following so it may be easier for me as an am dose.

I start Monday morning (my only day off) so we'll see

Offline nvgreene

  • Member
  • Posts: 14
  • Sweet!
    • Myspace profile
Re: The NEW pill
« Reply #24 on: July 21, 2006, 03:56:05 PM »
Scott, let me know how it goes, I'll be starting the following week

J
07/08/05

Offline Nadine

  • Member
  • Posts: 1,253
  • Member since: August 2005
Re: The NEW pill
« Reply #25 on: July 21, 2006, 06:10:53 PM »
I do not know if/when I will switch. I have the pt of view if something works, then y switch.

Hey Rob...My husband has the exact same feelings on this new med. 2 pills once a day is really no big deal. I can understand though, how this would really benefit a lot of people with the drug co pays and such. We are very fortunate to have good prescription coverage.

Guess we'll just wait and see. I'm anxious to hear from people who will be taking Atripla.

Offline terpie82

  • Member
  • Posts: 97
Re: The NEW pill
« Reply #26 on: July 21, 2006, 11:42:22 PM »
I'm going to NIH for my once every three-months appointment a week before Montreal, and I'm definitely asking them about this new drug. Hopefully I'll be switched over soon because I've been on Sustiva/Truvada for 2 years now. It'd be nice to do one pill once a day. I truly believe in a cure :)
Diagnosed in 2003
UD since 2004 and >35% (with one blip)

Offline ARMANDO

  • Member
  • Posts: 255
Re: The NEW pill
« Reply #27 on: July 22, 2006, 09:44:03 AM »
I FOR ONE WHOULD LIKE TO BELIEVE THATONE DAY WE WILL FIND A CURE FOR AIDS BUT CMON GUYS LETS GET REAL HERE,"THERE'S NO MONEY IN A CURE!!!THINK ABOUT IT !!!!!!

Offline terpie82

  • Member
  • Posts: 97
Re: The NEW pill
« Reply #28 on: July 22, 2006, 09:58:48 AM »
Hi Armando,
You're probably right in that there's no money in a cure...but then again, you have people who are are positive like me, in their 4th year of completing their PhD in Biology or those other scientists who aren't about the money, and are doing research for the sake of finding a cure. If I was about the money and didn't believe in a cure, I would have gone off to med-school instead. Those of us who believe in a cure can each contribute his/her own talent/skills to the cause.
Diagnosed in 2003
UD since 2004 and >35% (with one blip)

Offline Gilles

  • Member
  • Posts: 63
Re: The NEW pill
« Reply #29 on: July 22, 2006, 03:08:44 PM »
.I do hope for a cure...but at the same time I know that large companies such as Glaxo and Pfizer rather invent drugs that can control HIV  than completely eliminate the virus...so for this reason I think it will take longer for its emergence....
I am also bit concerned that if they invent the vaccine for the negative people...this will further slow down research for the cure....

Offline Steven

  • Member
  • Posts: 65
  • Joined: Dec 2002
    • A Place To Start
Re: The NEW pill
« Reply #30 on: July 23, 2006, 06:52:26 PM »
My doc mentioned this pill to me 3 months ago when I was in for my check up.
Now that it is out I guess he will ask me if I want it when he writes out those next round of scripts.

Offline Brian360

  • Member
  • Posts: 47
  • Just livin' it up until the sun goes down.
Re: The NEW pill
« Reply #31 on: July 24, 2006, 06:37:20 PM »
See what happens when Uncle Bill Gates infuses 287 million into HIV/AIDS research.
July06: Tcells 0, VL >+750,000
Aug06: TCells 22, VL 214,000
Sep06: TCells 32, VL 34,500
Oct06: TCells 92, VL 9,560
Dec06: Tcells 27, VL 25,000
Jan07: Tcells 43, VL - un-detect
Jan10: TCells 111 - popped to 160 fall 09, VL  undectable since Oct. 07

Offline ScottSoFla

  • Member
  • Posts: 4
Re: The NEW pill
« Reply #32 on: July 25, 2006, 11:45:03 AM »
Ok
I started Atripla yesterday and am happy to report nothing too eventful. The first few hours were a little weird but after that things seemed normal (as normal as you get in my world ;)). Same thing this morning. Dizzy, fuzzy and a little stoned feeling but that's it. But its basically the exact same thing as a Sustiva/Truvada combo in one big fat multi vitamin looking pill. Of course this is my first time on meds so I don't have a lot to compare it to. But so far so good.

Offline sfca415

  • Member
  • Posts: 20
  • love this place
Re: The NEW pill
« Reply #33 on: July 25, 2006, 12:17:03 PM »
There certainly is an appeal to one pill, once-daily.  It sounds great for those who don't have side-effects from the Sustiva element, or who are not resistant to non-nukes.  Anything to make life easier and to help us with adherence. 

For those who are starting out on any regimen, the new U.S. NIH treatment guidelines recommend that  a genotype test be done.  For instance, if your virus was already resistant to the non-nuke class (Sustiva/Viramune), you don't want to use Atripla as the first line of defense.

And how can we get too confused about the number of pills per day, when it's one/once daily?  When switching from Kaletra to Reyatz+Norvir, I somehow (after initially getting it right) later brain-scrambled the Rx of two caps, once a day (the Reyataz) into "take one daily."  Luckily I noticed after a couple of weeks that I had way too many capsules left in the bottle!  ;D
cd4+ 617 30% undetec - Jul06
cd4+ 221 17% 32K - Dec01
cd4+ 640 41% 5K - Feb96
current meds: Reyataz+Norvir, Viread, Epzicom, Valtrex, Wellbutrin
+ 1992, first meds 2002: Viramune (nvp), Zerit (d4t), Epivir (3tc) -- (m184v mutation & resistant to non-nukes, so no Atripla)

 


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