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Author Topic: PET Scans Used to Determine Progression of HIV Infection  (Read 792 times)

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Offline John2038

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PET Scans Used to Determine Progression of HIV Infection
« on: December 04, 2007, 02:03:33 AM »

While reading about PET-Scan on the net (were wondering if the radiations can cause the virus to mutate), found this interesting article:

Source: http://www.jhsph.edu/publichealthnews/press_releases/PR_2003/HIV_PET_scan.html

It suggest to use the PET-Scan to identify HIV the active lymphes nodes and to remove them.


Article extract

According to the study, the PET scans recorded activation of the lymph nodes, which are involved in the body’s immune response. Activation was most notable in lymph nodes in upper torso and neck areas of the body among participants recently infected with HIV.

Nodes in the lower torso were involved to a lesser extent. Participants who were infected with HIV for a longer period and remained asymptomatic with low viral loads also had lymph node activation in the neck, upper torso, and pelvic areas.

The researchers observed a tight correlation between the viral replication and the lymph node activity on the PET signal.

Lead author Sujatha Iyengar, PhD, and David Schwartz, MD, PhD, senior investigator of the study, propose that PET scans could be used to locate the specific nodes where HIV is replicating and remove them or target them with radiation.

“Although many systemic sites from which latent virus could be reactivated would be left, reactivation might not occur for months or years after removal of the active nodes, thereby allowing extended interruption of treatment for the disease.
Despite the systemic nature of HIV infection, the sites of viral replication appear remarkably restricted to limited anatomic locations at any given time. This suggests microenvironmental niche selection in true Darwinian fashion,” noted Dr. Schwartz, who is an associate professor with the School’s Department of Molecular Microbiology and Immunology.


 


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