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Author Topic: Week One on Isentress  (Read 4235 times)

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Offline Miss Philicia

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Week One on Isentress
« on: November 16, 2007, 01:13:53 AM »
I've now been on Isentress for an entire week and have the following report:  there have been no side effects.  Zilch.  Not a bit of nausea, no headaches, no diarrhea.

I've been on almost every HIV med on the market at one time or another, and each has always been touch and go the first month, some more than others.  Generally my body would adjust after the first month and I actually tolerated most meds pretty well, with the exception of all PI's which gave me massive amounts of diarrhea necessitating not the more common 1 or 2 imodiums but daily intakes of, at times, 20mg of imodium. 

Prezista, which I began a year and half ago, was the first HIV med to have the least amount of side effects for me, and those were most likely more due to the Norvir booster (diarrhea, though minimal compared with other stuff).  I still get some occasional nausea from Truvada though it's not a big deal, and it also give me bad gas maybe once each week.  Still overall this entire combination of meds I'm on are the absolute best, and have delivered marvelous lab results.  I have no worries about what my labs will be after the Isentress switch.

So finally, after 14 years of treatment I'm rather content.  Also, my ISR's from past Fuzeon use have no mostly disappeared on my abdomen with the exception of two knots, but they should be gone in another 3 days.
"I’ve slept with enough men to know that I’m not gay"

Dan J.

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Re: Week One on Isentress
« Reply #1 on: November 16, 2007, 01:22:07 AM »
I remember you saying that yoou would start taking Isentress after the drug was approved. So you take it in combination with Truvada? My doc told me he would probably prescribing it for me at some point in the near future. I can't take Truvada anmore so I wonder what he will combine the new drug with for me.

Thanks for the update & I hope it continues to do well for you.

 :-*

Offline Queen Tokelove

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Re: Week One on Isentress
« Reply #2 on: November 16, 2007, 01:30:09 AM »
Congrats, Philly....Onward and Upward... :-*
Started Atripla/Ziagen on 9/13/07.
10/31/07 CD4-265 VL- undetectable
2/6/08 CD4- 401 VL- undetectable
5/7/08 CD4- 705 VL- undetectable
6/4/08 CD4- 775 VL- undetectable
8/6/08 CD4- 805 VL- undetectable
11/13/08 CD4- 774 VL--undetectable
2/4/09  CD4- 484  VL- 18,000 (2 months off meds)
3/3/09---Starting Back on Meds---
4/27/09 CD4- 664 VL-- undetectable
6/17/09 CD4- 438 VL- 439
8/09 CD4- 404 VL- 1,600
01-22-10-- CD4- 525 VL- 59,000
Cherish the simple things life has to offer

The Royal Blog

Offline Miss Philicia

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Re: Week One on Isentress
« Reply #3 on: November 16, 2007, 01:36:17 AM »
So you take it in combination with Truvada?

Yes, but also with Prezista and Norvir.  So basically that's four HIV meds.  Well, not five I guess because Truvada is actually really two meds in one pill.

It's still lots of pills when you figure that I *still* take imodium daily, and my pancreatic enzyme.  Oh, then a blood pressure pill and PN medication.

*sigh* that's till 23 pills each day :(  I think a few years ago I was taking 35  or more so that's still an improvement for me!

* mother's-little-helper pills not included
"I’ve slept with enough men to know that I’m not gay"

Offline Dragonette

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Re: Week One on Isentress
« Reply #4 on: November 16, 2007, 03:34:27 AM »
Congrats & good luck with the new combo, onwards & upwards as Queen said!
"If you keep one foot in yesterday, and one in tomorrow, you piss all over today". Betty Tacy

Offline BT65

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Re: Week One on Isentress
« Reply #5 on: November 16, 2007, 07:18:16 AM »
Glad to hear it's working well for you, Philly.  I hope things continue to go so good!
I've never killed anyone, but I frequently get satisfaction reading the obituary notices.-Clarence Darrow

Offline mjmel

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Re: Week One on Isentress
« Reply #6 on: November 16, 2007, 07:42:04 AM »
Glad to read you are reasonably content after 14 years of sticking with harsh-as-hell drug regiments. Bet you are glad you waded through those tough experiences and didn't become disheartened enough to give up. A testimony of encouragement to newbies and old timers alike.
Isentress replaces the shots of Fuzeon, is that correct?  Say "Hallelujah!" sista-man.  :D
Must be a BIG relief not to have to stick yourself everyday, David. Good luck and continued success with the new drug.
xxx,
Mike

Offline Robert

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Re: Week One on Isentress
« Reply #7 on: November 16, 2007, 11:11:06 AM »
this is good news philly.  glad to hear it.  But god that's still a shitload of pills.

Any news from Rab?  How's he doing on it?  Anyone else here on it?  How are they doing?

robert
..........

Offline StrongGuy

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Re: Week One on Isentress
« Reply #8 on: November 16, 2007, 12:18:43 PM »
Glad to hear Philly...

It's good to get a read on the newer meds if I ever do have to explore new options down the road.

:)
"Get your medical advice from Doctors or medical professionals who you trust and know your history."

"Beware of the fortune teller doom and gloomers who seek to bring you down and are only looking for company, purpose and validation - not your best physical/mental interests."

"You know you all are saying that this is incurable. When the real thing you should be saying is it's not curable at the present time' because as we know, the great strides we've made in medicine." - Elizabeth Edwards

Offline AlanBama

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Re: Week One on Isentress
« Reply #9 on: November 16, 2007, 12:22:49 PM »
That's great news!   I love to hear that there are NO side effects !   It's amazing really...

Hope you continue to do well with it.

hugs, Alan
"Remember my sentimental friend that a heart is not judged by how much you love, but by how much you are loved by others." - The Wizard of Oz

Offline keyite

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Re: Week One on Isentress
« Reply #10 on: November 16, 2007, 12:24:33 PM »
Must be a huge relief for you! It's also very reassuring to know easier and better tolerated meds like Isentress are becoming available.

Offline komnaes

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Re: Week One on Isentress
« Reply #11 on: November 16, 2007, 12:26:34 PM »
Great news Philly...  ;D
Aug 07 Diagnosed
Oct 07 CD4=446(19%) Feb 08 CD4=421(19%)
Jun 08 CD4=325(22%) Jul 08 CD4=301(18%)
Sep 08 CD4=257/VL=75,000 Oct 08 CD4=347(16%)
Dec 08 CD4=270(16%)
Jan 09 CD4=246(13%)/VL=10,000
Feb 09 CD4=233(15%)/VL=13,000
Started meds Sustiva/Epzicom
May 09 CD4=333(24%)/VL=650
Aug 09 CD4=346(24%)/VL=UD
Nov 09 CD4=437(26%)/VL=UD
Feb 10 CD4=471(31%)/VL=UD
June 10 CD4=517 (28%)/VL=UD
Sept 10 CD4=687 (31%)/VL=UD
Jan 11 CD4=557 (30%)/VL=UD
April 11 CD4=569 (32%)/VL=UD
Switched to Epizcom, Reyataz and Norvir
(Interrupted for 2 months with only Epizcom & Reyataz)
July 11 CD=520 (28%)/VL=UD
Oct 11 CD=771 (31%)/VL=UD(<30)
April 12 CD=609 (28%)/VL=UD(<20)
Aug 12 CD=657 (29%)/VL=UD(<20)
Dec 12 CD=532 (31%)/VL=UD(<20)
May 13 CD=567 (31%)/VL=UD(<20)
Jan 14 CD=521 (21%)/VL=UD(<50)

Offline bear60

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Re: Week One on Isentress
« Reply #12 on: November 16, 2007, 01:21:18 PM »
David
I know injecting yourself is no fun. So it must be a big relief to be able to take this in pill form.  Congrats!
Poz Bear Type in Philadelphia

Offline SoSadTooBad

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Re: Week One on Isentress
« Reply #13 on: November 16, 2007, 07:31:28 PM »
Philly - great news!!  Enjoy your holidays!!

Offline northernguy

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Re: Week One on Isentress
« Reply #14 on: November 16, 2007, 09:37:11 PM »
That is great news, for you and others looking at some of the new drugs as therapy.  Congrats :)
Apr 28/06 cd4 600 vl 10,600 cd% 25
Nov 8/09 cd4 510 vl 49,5000 cd% 16
Jan 16/10 cd4 660 vl 54,309 cd% 16
Feb 17/10 Started Atripla
Mar 7/10 cd4 710 vl 1,076 cd% 21
Apr 18/10 cd4 920 vl 268 cd% 28
Jun 19/10 cd4 450 vl 60 cd% 25
Aug 15/10 cd4 680 vl 205 cd% 27
Apr 3/11 cd4 780 vl <40 cd% 30
Jul 17/11 cd4 960 vl <40 cd%33
April 15/12 cd4 1,010 vl <40 cd% 39
April 20/12 Switched to Viramune + Truvada
Aug 2/12 cd4 1040, vl <40, cd% 38
Oct 19 cd4 1,110 vl <40 cd% 41

Offline xyahka

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Re: Week One on Isentress
« Reply #15 on: November 17, 2007, 10:15:53 PM »
so glad to hear the good news Philly, felicitaciones :)

mucha suerte y que todo siga bien!!!

Juan Carlos
13/03/07 1er diagnóstico /Peso: 79kg
19/04/07 CD4: 494 /CViral: ?? /Peso: 80kg
19/07/07 CD4: 659 /CViral: ?? /Peso: 79.5kg
06/03/08 CD4: 573 (después de meses muy deprimido) /CViral: ?? /Peso: 79kg
17/09/08 CD4: ?? /CViral: ?? /Peso: 84Kg
06/02/09 CD4: ?? /CViral: ?? /Peso: 85Kg /HCV: Neg /HBV: Neg.
07/03/09 CD4: ?? /CViral: ?? /Peso: 87Kg / Gym 3días/semana y Natación 2días/semana.
12/05/09 CD4: 470 /Cviral: ?? /Peso: 87Kg.
08/07/09 CD4: ? /CViral: ? /Peso: 77Kg.
09/12/09 CD4: 510 /CViral: ? /Peso: 78kg. No medicinas aún
10/01/10 CD4: ? /CViral: ? /Peso: 76Kg.
15/05/10 CD4: 320 /CViral: ? /Peso: 76Kg.
01/02/11 CD4: 291 /CViral: ? /Peso: 78kg.
05/05/11 CD4: 366 /CViral: ? /Peso: 78kg.
27/07/11 CD4: 255 /CViral: 138000 /Peso: 78kg.

Disfrutando y aceptando una nueva vida...

Offline milker

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Re: Week One on Isentress
« Reply #16 on: November 21, 2007, 12:02:09 AM »
That's pretty cool, Philly. Now you can use poppers again  :o

Milker.
mid-dec: stupid ass
mid-jan: seroconversion
mid-feb: poz
mar 07: cd4 432 (35%) vl 54000
may 07: cd4 399 (28%) vl 27760
jul 07: cd4 403 (26%) vl 99241
oct 07: cd4 353 (24%) vl 29993
jan 08: cd4 332 (26%) vl 33308
mar 08: cd4 392 (23%) vl 75548
jun 08: cd4 325 (27%) vl 45880
oct 08: cd4 197 (20%) vl 154000 <== aids diagnosis
nov 2 08 start Atripla
nov 30 08: cd4 478 (23%) vl 1880 !!!!!!!!!!!!!!!!!!!!!!!!!!
feb 19 09: cd4 398 (24%) vl 430 getting there!
apr 23 09: cd4 604 (29%) vl 50 woohoo :D :D
jul 30 09: cd4 512 (29%) vl undetectable :D :D
may 27 10: cd4 655 (32%) vl undetectable :D :D

Now accepting applications from blowjob ninjas™

Offline Esquare

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Re: Week One on Isentress
« Reply #17 on: November 21, 2007, 12:06:51 AM »
Great news to hear all around! Glad to hear it.

Offline fearless

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Re: Week One on Isentress
« Reply #18 on: November 22, 2007, 03:29:19 AM »
great news philly. you must be pleased.
Be forgiving, be grateful, be optimistic

Offline Miss Philicia

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Re: Week One on Isentress
« Reply #19 on: January 02, 2008, 02:22:37 PM »
So, I finally received my first labs since beginning Isentress almost 2 months ago and I'm still undetectable, and I also had a not-shoddy +160 cd4 bump.
"I’ve slept with enough men to know that I’m not gay"

Offline MSPspud

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Re: Week One on Isentress
« Reply #20 on: January 02, 2008, 05:07:41 PM »
So, I finally received my first labs since beginning Isentress almost 2 months ago and I'm still undetectable, and I also had a not-shoddy +160 cd4 bump.

No new side effects or insights?

Offline Miss Philicia

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Re: Week One on Isentress
« Reply #21 on: January 02, 2008, 05:27:08 PM »
Oh, I commented on the utter lack of any side effects in the first post in this thread but that was at the end of the first week.  Nothing changed after that -- absolutely NO side effects.  Amazing drug.

If you've not read up on Isentress it's in an entirely new class of HIV med -- integrase inhibitors.  Because it blocks integrase which HIV needs to insert its viral genetic information into infected cells.  I'm not a brilliant scientist, but it's my understanding that integrase inhibitors are so promising because this method of attack is happening more at the beginning of the whole HIV cell infection cycle than other existing HIV meds, though perhaps someone smarter than me can clarify this.
"I’ve slept with enough men to know that I’m not gay"

Offline MSPspud

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Re: Week One on Isentress
« Reply #22 on: January 02, 2008, 05:41:01 PM »
I mentioned Isentress to my doctor because I was thinking it would be nice to take a liver break from protease inhibitors but he feels uncomfortable about its unknown interactions with cellular DNA and the implications of what could be turned on/off.  He said I need to wait and see - besides, I'm having no issues with Prezista.  I am thinking it might be a good option in the future because I do believe its important to not constantly block the same liver enzymes with Ritonavir.  I am fortunate enough to have a strong enough NRTI susceptibility to do a switch like this when there's more data.

Thanks for the update and for being on the forefront of this treatment. 

Offline AlanBama

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Re: Week One on Isentress
« Reply #23 on: January 02, 2008, 06:37:03 PM »
Congrats on the numbers, and glad you are still doing so well with it.

No side effects......wow that seems almost too good to be true.   Enjoy it!

hugs,

Alan
"Remember my sentimental friend that a heart is not judged by how much you love, but by how much you are loved by others." - The Wizard of Oz

Offline Jeffreyj

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Re: Week One on Isentress
« Reply #24 on: January 02, 2008, 08:27:57 PM »
Glad to hear you are doing so well. One question, though...How did you get on Prezista a year and a half ago? My DR said it just recently became available....

I'm on both also. I love not having to "Shoot up" twice a day...Keep up the good work man!
Positive since 1985

Offline Miss Philicia

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Re: Week One on Isentress
« Reply #25 on: January 02, 2008, 08:58:06 PM »
No, Prezista was FDA approved in June, 2006

http://en.wikipedia.org/wiki/Darunavir

I began Prezista on a drug trial, but only a couple of months before FDA approval.  Isentress is the one that was just approved.
"I’ve slept with enough men to know that I’m not gay"

Offline Jeffreyj

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Re: Week One on Isentress
« Reply #26 on: January 02, 2008, 10:00:19 PM »
I get my first labs since I've been on Prezista and Isentress. I am kind of nervous, because my numbers on Kaletra and fuzeon were so good.
I hope I have the same good results you have had!

My Dr is convienced that Kaletra may be the reason for my recent diabetes diagnoses...Looks like I should have been on Prezista a bit earlier. Damn.
Positive since 1985

Offline Central79

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Re: Week One on Isentress
« Reply #27 on: January 03, 2008, 02:48:05 PM »
Hey Philly

I'm really happy you're doing so well on Isentress. My clinic nurse told me that it's looking so good that it might be the standard of care for treatment naive patients in a couple of years...

Long may it continue!

Matt.
Diagnosed January 2006
26/1/06 - 860 (22%), VL > 500,000
24/4/06 - 820 (24.6%), VL 158,000
13/7/06 - 840 (22%), VL 268,000
1/11/06 - 680 (21%), VL 93,100
29/1/07 - 1,020 (27.5%), VL 46,500
15/5/07 - 1,140 (22.8%), VL not done.
13/10/07 - 759 (23.2%), VL 170,000
6/11/07 - 630 (25%), VL 19,324
14/1/08 - 650 (21%), VL 16,192
15/4/08 - 590 (21%), VL 40, 832

Offline PeteNYNJ

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Re: Week One on Isentress
« Reply #28 on: January 03, 2008, 04:35:25 PM »
Good to hear, Philly

Here is to good number and good health in the coming year.

Pete

 


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