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Author Topic: No new PIs?  (Read 3498 times)

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Offline a2z

  • Member
  • Posts: 193
No new PIs?
« on: October 29, 2007, 02:46:16 AM »
I was looking at the drug chart tonight, and noticed there are several new drugs in the works, but none in the PI class.  Is there a reason for this that anyone knows of?
Dates are blood draw dates:
5/23/14: CD4 895 --.-% VL UD - Truvada/Isentress
09/21/09: CD4 898 27.0% VL 120 - back on track, same meds.High level enzymes, but less so
06/15/09: CD4 478 21.8% VL 1150 - high liver enzymes... looks like I may not be resistant
05/22/09: Fixed insurance, resumed medicine
04/17/09: Ran out of medicine, could not resolve insurance problems
04/01/09: CD4 773 28% VL 120 - high liver enzymes
12/01/08: CD4 514 23% VL 630
10/17/08 started Reyataz, Norvir and Truvada. -- possibly minor neuropathy, but otherwise okay.
9/10/08: CD4 345 17%, VL > 78K
8/18/08: CD4 312 18%, VL > 60K (considering meds)
12/19/07: CD4 550 28% VL > 100K (no meds yet)
Diagnosed 10/23/07

Offline ronaldinho

  • Member
  • Posts: 79
Re: No new PIs?
« Reply #1 on: October 29, 2007, 07:44:15 AM »
Darunavir ( = prezista), from Tibotec, is the most recent PI approved.

http://hivandhepatitis.com/recent/2007/102607_d.html

The only other that i could found to to be in development is PPL-100 from Merck. But if you look in the menu of ARVs in the link above, PIs and NRTIs are the classes with the most variety of options.
« Last Edit: October 29, 2007, 07:52:03 AM by ronaldinho »

Offline ronaldinho

  • Member
  • Posts: 79
Re: No new PIs?
« Reply #2 on: October 29, 2007, 07:52:48 AM »
wrong message

Offline a2z

  • Member
  • Posts: 193
Re: No new PIs?
« Reply #3 on: November 05, 2007, 02:32:09 AM »
Well I found part of my answer here http://img.thebody.com/tag/pipeline.pdf

Is this just because PIs are "old news?" and the rest is more exciting (and potentially more profitable?)
Dates are blood draw dates:
5/23/14: CD4 895 --.-% VL UD - Truvada/Isentress
09/21/09: CD4 898 27.0% VL 120 - back on track, same meds.High level enzymes, but less so
06/15/09: CD4 478 21.8% VL 1150 - high liver enzymes... looks like I may not be resistant
05/22/09: Fixed insurance, resumed medicine
04/17/09: Ran out of medicine, could not resolve insurance problems
04/01/09: CD4 773 28% VL 120 - high liver enzymes
12/01/08: CD4 514 23% VL 630
10/17/08 started Reyataz, Norvir and Truvada. -- possibly minor neuropathy, but otherwise okay.
9/10/08: CD4 345 17%, VL > 78K
8/18/08: CD4 312 18%, VL > 60K (considering meds)
12/19/07: CD4 550 28% VL > 100K (no meds yet)
Diagnosed 10/23/07

Online Miss Philicia

  • Member
  • Posts: 24,107
  • celebrity poster, faker & poser
Re: No new PIs?
« Reply #4 on: November 05, 2007, 04:21:30 AM »
Aside from Prezista which was mentioned (and which came out a year ago) Aptivus is also new (in the last 2 years) -- that's 10 PI's now so I'm not sure why they would want to glut the market.

However, these PI's are slightly different as they're better for people with PI resistance issues.  As well, all of the new HIV meds that are non-PI like Isentress, Selzentry and Etravirine are also aimed at patients with multiple resistance issues.

I'm not sure why you want what seems "more of the same" -- the longer we all live the more resistance issues all of us will face, so these other class drugs are needed.  Plus entire new classes, like Isentress is as an integrase inhibitor, will eventually (I assume) be used as more of a first line treatment once it's studied more, and could very well prove more effective and tolerable in terms of side effects than what we have now.
"Iíve slept with enough men to know that Iím not gay"

Offline MitchMiller

  • Member
  • Posts: 479
Re: No new PIs?
« Reply #5 on: November 05, 2007, 10:55:09 PM »
Pl-100 is a new PI that's looking potent.  I forget who's developing it but here's a recent blurb on it:
http://aac.asm.org/cgi/content/abstract/51/11/4036 
Sorry... I see PL-100 is the same as PPL-100 that has already been mentioned in the thread.  Here's the original developer of that drug (they licensed it to Merck)....
http://www.ambrilia.com/en/products/hiv-aids-ppl-100.php
« Last Edit: November 05, 2007, 10:57:41 PM by MitchMiller »

Offline a2z

  • Member
  • Posts: 193
Re: No new PIs?
« Reply #6 on: November 06, 2007, 12:03:07 AM »
I'm not sure why you want what seems "more of the same" -- the longer we all live the more resistance issues all of us will face, so these other class drugs are needed.  Plus entire new classes, like Isentress is as an integrase inhibitor, will eventually (I assume) be used as more of a first line treatment once it's studied more, and could very well prove more effective and tolerable in terms of side effects than what we have now.

It was not "wanting more of the same" -- it was curiousity as to why research seems to have stopped on this one type.  I'm still learning and it seemed like a logical question I couldn't really find the answer for myself.

But I think you gave a pretty thorough hypothesis as to why and I appreciate it.
Dates are blood draw dates:
5/23/14: CD4 895 --.-% VL UD - Truvada/Isentress
09/21/09: CD4 898 27.0% VL 120 - back on track, same meds.High level enzymes, but less so
06/15/09: CD4 478 21.8% VL 1150 - high liver enzymes... looks like I may not be resistant
05/22/09: Fixed insurance, resumed medicine
04/17/09: Ran out of medicine, could not resolve insurance problems
04/01/09: CD4 773 28% VL 120 - high liver enzymes
12/01/08: CD4 514 23% VL 630
10/17/08 started Reyataz, Norvir and Truvada. -- possibly minor neuropathy, but otherwise okay.
9/10/08: CD4 345 17%, VL > 78K
8/18/08: CD4 312 18%, VL > 60K (considering meds)
12/19/07: CD4 550 28% VL > 100K (no meds yet)
Diagnosed 10/23/07

Offline ronaldinho

  • Member
  • Posts: 79
Re: No new PIs?
« Reply #7 on: November 30, 2007, 01:40:25 PM »
A good overview on antiretrovirals in development can be found  in the pdf document (pages 45 to 78) downloadable in the link below:

http://www.hivmedicine.com/hivmedicine2007.pdf

 


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