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Author Topic: Potent peptides inhibit HIV cell entry  (Read 2921 times)

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Offline mark86

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  • Posts: 33
Potent peptides inhibit HIV cell entry
« on: October 11, 2007, 03:49:30 PM »
Hi,
Found this in Science Daily,



Potent peptides inhibit HIV cell entry
UPTON, N.Y., Oct. 11 (UPI) -- U.S. scientists have developed peptides significantly more effective at blocking the human immunodeficiency virus from entering cells.

Based in part on protein structures determined at the National Synchrotron Light Source at the U.S. Department of Energy's Brookhaven National Laboratory, researchers said their peptides are sufficiently potent to begin pre-clinical studies as a potential new class of agents for the prevention and treatment of HIV and AIDS.

"Our 'D-peptides' offer several potential therapeutic advantages over existing peptide entry inhibitors, which are costly, require high dose injections, and suffer from the emergence of drug-resistance," said University of Utah biochemist Michael Kay, lead author of the study. "In contrast, our D-peptides resist degradation, so they have the potential to be administered by mouth and last longer in the bloodstream. Since these inhibitors have a unique inhibitory mechanism, they should work well in combination with existing HIV inhibitors."

The work appears in the early online edition of the Proceedings of the National Academy of Sciences

Mark86

Offline J220

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  • Posts: 587
Re: Potent peptides inhibit HIV cell entry
« Reply #1 on: October 11, 2007, 10:29:24 PM »
Excellent news.
"Hope is my philosophy
Just needs days in which to be
Love of Life means hope for me
Born on a New Day" - John David

Offline milker

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Re: Potent peptides inhibit HIV cell entry
« Reply #2 on: October 11, 2007, 10:32:25 PM »
I wonder if the german peptides that were talked about a couple of month ago were L or D peptides? I also wonder if D-amino acids have been extensively used in other treatments since they are not natural in the human body.. time to do some research!

Milker.
mid-dec: stupid ass
mid-jan: seroconversion
mid-feb: poz
mar 07: cd4 432 (35%) vl 54000
may 07: cd4 399 (28%) vl 27760
jul 07: cd4 403 (26%) vl 99241
oct 07: cd4 353 (24%) vl 29993
jan 08: cd4 332 (26%) vl 33308
mar 08: cd4 392 (23%) vl 75548
jun 08: cd4 325 (27%) vl 45880
oct 08: cd4 197 (20%) vl 154000 <== aids diagnosis
nov 2 08 start Atripla
nov 30 08: cd4 478 (23%) vl 1880 !!!!!!!!!!!!!!!!!!!!!!!!!!
feb 19 09: cd4 398 (24%) vl 430 getting there!
apr 23 09: cd4 604 (29%) vl 50 woohoo :D :D
jul 30 09: cd4 512 (29%) vl undetectable :D :D
may 27 10: cd4 655 (32%) vl undetectable :D :D

Now accepting applications from blowjob ninjas™

Offline J220

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Re: Potent peptides inhibit HIV cell entry
« Reply #3 on: October 12, 2007, 08:45:19 PM »
Agreed...where's Bizmarek??? Time to shine the giant B in the night sky! lol Cheers, J.
"Hope is my philosophy
Just needs days in which to be
Love of Life means hope for me
Born on a New Day" - John David

Online Miss Philicia

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Re: Potent peptides inhibit HIV cell entry
« Reply #4 on: October 12, 2007, 08:52:21 PM »
When you google "bimazek" the first hit is "PD-1 Research"
"I’ve slept with enough men to know that I’m not gay"

Offline milker

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Re: Potent peptides inhibit HIV cell entry
« Reply #5 on: October 12, 2007, 09:31:47 PM »
Of course, why research D-peptide human studies when we're going to have an extensive post in a couple of days. I forgot about that LOL :D

Milker.
mid-dec: stupid ass
mid-jan: seroconversion
mid-feb: poz
mar 07: cd4 432 (35%) vl 54000
may 07: cd4 399 (28%) vl 27760
jul 07: cd4 403 (26%) vl 99241
oct 07: cd4 353 (24%) vl 29993
jan 08: cd4 332 (26%) vl 33308
mar 08: cd4 392 (23%) vl 75548
jun 08: cd4 325 (27%) vl 45880
oct 08: cd4 197 (20%) vl 154000 <== aids diagnosis
nov 2 08 start Atripla
nov 30 08: cd4 478 (23%) vl 1880 !!!!!!!!!!!!!!!!!!!!!!!!!!
feb 19 09: cd4 398 (24%) vl 430 getting there!
apr 23 09: cd4 604 (29%) vl 50 woohoo :D :D
jul 30 09: cd4 512 (29%) vl undetectable :D :D
may 27 10: cd4 655 (32%) vl undetectable :D :D

Now accepting applications from blowjob ninjas™

Offline J220

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  • Posts: 587
Re: Potent peptides inhibit HIV cell entry
« Reply #6 on: October 13, 2007, 08:18:07 AM »
(for the record Biz, if you're out there, I'm looking forward to your posts. J).
"Hope is my philosophy
Just needs days in which to be
Love of Life means hope for me
Born on a New Day" - John David

Online Miss Philicia

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  • Posts: 23,872
  • celebrity poster, faker & poser
Re: Potent peptides inhibit HIV cell entry
« Reply #7 on: October 13, 2007, 10:53:33 AM »
All things being equal, it's REALLY AMAZING what you can find on google these days.  Seriously.
"I’ve slept with enough men to know that I’m not gay"

Offline Cerrid

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Re: Potent peptides inhibit HIV cell entry
« Reply #8 on: October 13, 2007, 11:35:41 AM »
I wonder if the german peptides that were talked about a couple of month ago were L or D peptides?

The german peptides (VIRIP) were L-peptides, they occur naturally in the human body. But because they're very small, they were only discovered recently. They possess an anti-HIV effect by binding to the viral fusion protein, thus preventing fusion with the host cell. The findings were published in Cell.

Now, the same mode of action is described for the  Utah peptides above. While there are some natural occurring D-peptides (e.g. some bacteria use them to build cell walls), the ones mentioned above are synthetic. Because they're not as easily degraded as their mirror brothers, they have a higher potential as drugs.

Either way, using proteins as drugs to block virus entry is an interesting new concept. Hopefully, we'll see some studies how they behave in animals and humans.
« Last Edit: October 13, 2007, 11:39:16 AM by Cerrid »
"Boredom is always counterrevolutionary. Always." (Guy Debord)

Offline bimazek

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  • Posts: 781
Re: Potent peptides inhibit HIV cell entry
« Reply #9 on: October 13, 2007, 10:41:34 PM »
I have not read all the details of this new potent peptide yet.  But over last 16 months i have read a heck of alot on a bunch of naturally produced pro line rich poly peptides that the mother produces in the colostrum milk that we all learn is the first milk that helps start up a babies immune system.  There are products, i have been taking a colostrum liquid, and imagine (no proof) that it helps the immune system, but then i have had many issues with my health even while taking the colostrum that makes me wonder if this does anything at all it does not stop my t cells from falling.  But i am talking about colostrum and not this new potent peptide.

I first got amazed by aminos and proteins when 15 years ago i swam into a tenticle of a jelly fish in kialua bay oahu
it was clear but there was some clouds on horizon and wind, and this thing must have had 20 ft long tenticles and one brushed against my bicep when i was swimming, well instantly the arm had a huge big swelling, about size of a  finger where the tentical touched, what was in the jelly fish, only an amino acid, i thought these things must be frickin powerful to cause this reaction so so fast, my arm was deformed in a way and pain and swelling

i cant focus tonight on writing but i will read more of this


Offline milker

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Re: Potent peptides inhibit HIV cell entry
« Reply #10 on: October 13, 2007, 11:32:32 PM »
Please don't start telling us that we have to drink breast milk.

D amino acids are NOT produced by in the human body. Proteins are made of amino acids, and jelly fish releases toxins that are proteins and enzymes made of amino acids, i'm not sure what you're trying to say here.

Milker.

PS: there are more than 300 amino acids.
mid-dec: stupid ass
mid-jan: seroconversion
mid-feb: poz
mar 07: cd4 432 (35%) vl 54000
may 07: cd4 399 (28%) vl 27760
jul 07: cd4 403 (26%) vl 99241
oct 07: cd4 353 (24%) vl 29993
jan 08: cd4 332 (26%) vl 33308
mar 08: cd4 392 (23%) vl 75548
jun 08: cd4 325 (27%) vl 45880
oct 08: cd4 197 (20%) vl 154000 <== aids diagnosis
nov 2 08 start Atripla
nov 30 08: cd4 478 (23%) vl 1880 !!!!!!!!!!!!!!!!!!!!!!!!!!
feb 19 09: cd4 398 (24%) vl 430 getting there!
apr 23 09: cd4 604 (29%) vl 50 woohoo :D :D
jul 30 09: cd4 512 (29%) vl undetectable :D :D
may 27 10: cd4 655 (32%) vl undetectable :D :D

Now accepting applications from blowjob ninjas™

 


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