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Author Topic: Immune changes in exposed, uninfected partners of people with HIV correlate with  (Read 1686 times)

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Offline ronaldinho

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  • Posts: 79
This piece of news is very interesting, but what really caught my attention was this:

"Changes from normal immune function in the exposed, uninfected sexual partners of people with HIV, is driven by continued exposure to their partner’s virus . However these responses were not HIV-specific; exposure to HIV seemed to result in a generally heightened state of ‘infection preparedness’ rather than a specific reaction to HIV. "

"Were they immune to attack because they had developed specific responses to their partner’s HIV, as if vaccinated by viral antigens? This does not appear to be the case since one of the striking findings of the study was that hardly any of the exposed seronegative partners had immune responses - either cellular or humoral (antibody) – which were specific for HIV. "

So, the reason why some people never get infected  despite continued exposure could be that their immune system is somewhat disfunctional, in the sense that they are not able to produce antibodies speficic to HIV? Maybe HIV depends on the production of these specific antibodies to establish infection, since HIV needs to  enter defense cells to start reproducing? If this were true, then the trick to avoid HIV infection would be to teach the immune system to ignore HIV (maybe this is unfeasible, i do not know), instead of trying to stimulate it to fight HIV.








Offline milker

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Offline milker

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Very interesting article, thanks for sharing !

Milker.
mid-dec: stupid ass
mid-jan: seroconversion
mid-feb: poz
mar 07: cd4 432 (35%) vl 54000
may 07: cd4 399 (28%) vl 27760
jul 07: cd4 403 (26%) vl 99241
oct 07: cd4 353 (24%) vl 29993
jan 08: cd4 332 (26%) vl 33308
mar 08: cd4 392 (23%) vl 75548
jun 08: cd4 325 (27%) vl 45880
oct 08: cd4 197 (20%) vl 154000 <== aids diagnosis
nov 2 08 start Atripla
nov 30 08: cd4 478 (23%) vl 1880 !!!!!!!!!!!!!!!!!!!!!!!!!!
feb 19 09: cd4 398 (24%) vl 430 getting there!
apr 23 09: cd4 604 (29%) vl 50 woohoo :D :D
jul 30 09: cd4 512 (29%) vl undetectable :D :D
may 27 10: cd4 655 (32%) vl undetectable :D :D

Now accepting applications from blowjob ninjas™

 


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