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Author Topic: Wistar Institute - vaccine that stimulates the production of anti-HIV 9-07  (Read 1810 times)

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Offline bimazek

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vaccine that stimulates the production of anti-HIV CD8+ T cells, which have been shown to reduce viral load

http://www.medicalnewstoday.com/articles/81269.php
Sep 2007
"Based what we know about HIV and the immune system's response to the virus, it may not be possible to create a vaccine that generates antibodies able to neutralize HIV," says Ertl. "For this reason, we and others are now focusing our attention on developing a vaccine that stimulates the production of anti-HIV CD8+ T cells, which have been shown to reduce viral load, although they do not prevent infection. Our vaccine has induced unprecedented levels of activated CD8+ T cells in experimental animals, and we are eager to see if it can perform as well in humans."

The Wistar Institute is an international leader in biomedical research, with special expertise in cancer research and vaccine development. Founded in 1892 as the first independent nonprofit biomedical research institute in the country, Wistar has long held the prestigious Cancer Center designation from the National Cancer Institute. Discoveries at Wistar have led to the creation of the rubella vaccine that eradicated the disease in the U.S., rabies vaccines used worldwide, and a new rotavirus vaccine approved in 2006

Offline bimazek

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Re: Wistar Institute - vaccine that stimulates the production of anti-HIV 9-07
« Reply #1 on: September 23, 2007, 07:37:58 PM »
call this an anti-HIV CD8+ T cell Vaccine
in other words
vaccine researchers seeing importance of cd8 in vaccine development

Offline milker

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Re: Wistar Institute - vaccine that stimulates the production of anti-HIV 9-07
« Reply #2 on: September 24, 2007, 07:53:53 PM »
CD8s also stop B-cell activity, decreasing the level of immunity. Too many Cd8 can shut off the immune response. This is a natural autodefense from the body to avoid overwhelming itself.

Milker.
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mid-jan: seroconversion
mid-feb: poz
mar 07: cd4 432 (35%) vl 54000
may 07: cd4 399 (28%) vl 27760
jul 07: cd4 403 (26%) vl 99241
oct 07: cd4 353 (24%) vl 29993
jan 08: cd4 332 (26%) vl 33308
mar 08: cd4 392 (23%) vl 75548
jun 08: cd4 325 (27%) vl 45880
oct 08: cd4 197 (20%) vl 154000 <== aids diagnosis
nov 2 08 start Atripla
nov 30 08: cd4 478 (23%) vl 1880 !!!!!!!!!!!!!!!!!!!!!!!!!!
feb 19 09: cd4 398 (24%) vl 430 getting there!
apr 23 09: cd4 604 (29%) vl 50 woohoo :D :D
jul 30 09: cd4 512 (29%) vl undetectable :D :D
may 27 10: cd4 655 (32%) vl undetectable :D :D

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