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Author Topic: Article on Selzentry  (Read 1338 times)

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Offline next2u

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  • Posts: 1,762
Article on Selzentry
« on: September 20, 2007, 01:28:39 AM »
CHICAGO (AFP) - Pharmaceuticals giant Pfizer Tuesday unveiled a new anti-AIDS drug which it said could help HIV patients stay healthy for longer.

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Selzentry is the first new class of oral HIV medicines to be introduced in more than 10 years, Pfizer said at an annual medical conference in Chicago.

After a 48-week trial, nearly three times as many patients receiving the drug combined with traditional medication recorded undectectable levels of HIV virus, compared with those just getting the normal treatments.

"The safety and durability of response seen with Selzentry ... in our study is reassuring. This drug is an important new weapon for clinicians who treat HIV," said Jacob Lalezari, director of Quest Clinical Research, at the University of California.

The US Food and Drug Administration in August approved the use of Selzentry, which is the first in a class of drugs called CCR5 antagonists. They prevent the virus from entering the body's T-cells, rather than fighting the virus once it is already infected the cells.

The drug does not however cure HIV infection or prevent it from being passed to another person, the company warned.

The side-effects are similar to those experienced with other anti-AIDS drugs, including nausea, fatigue, headaches and diarrhea.

Experts believe the eventual sales of the drug could generate 500 million dollars for Pfizer annually by 2011. The company is also seeking permission for worldwide sales.

midapr07 - seroconversion
sept07 - tested poz
oct07 cd4 1013; vl 13,900; cd4% 41
feb08 cd4  694;  vl 16,160; cd4% 50.1
may08 cd4 546; vl 91,480; cd4% 32
aug08 cd4 576; vl 48,190; cd4% 40.7
dec08 cd4 559; vl 63,020; cd4% 29.4
feb09 cd4 464; vl 11,000; cd4% 26
may09 cd4 544; vl 29,710; cd4% 27.2
oct09 cd4 ...; vl 23,350; cd4% 31.6
mar10 cd4 408; vl 59,050; cd4% 31.4
aug10 cd4 328; vl 80,000; cd4% 19.3 STARTED ATRIPLA
oct10 cd4 423; vl 410 ;); cd4% 30.2
jun11 cd4 439; vl <20 ;); cd4% 33.8 <-Undetectable!
mar12 cd4 695; vl ud; cd4% 38.6
jan13 cd4 738; vl ud; cd4% 36.8
aug13 cd4 930; vl ud; cd4% 44.3
jan14 cd4 813; vl ud; cd4% 42.8
may14 cd4 783; vl *; cd4%43.5

Offline Tim Horn

  • Member
  • Posts: 799
Re: Article on Selzentry
« Reply #1 on: September 26, 2007, 03:48:11 PM »
We just posted this "primer" on Selzentry, CCR5 antagonists, and the much larger topic of tropism. It might be of interest to some of the treatment followers in the Forums.

Tim Horn

Offline milker

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  • Posts: 4,034
  • Protected phone sex
Re: Article on Selzentry
« Reply #2 on: September 26, 2007, 10:59:32 PM »
The X4 bonding is a bit problematic. I see all those drugs concentrating on R5 but I remember a study that said that R5 was expressed by only 15% of T4. Still, R5 medication seems to bring the VL to undetectable levels, so i'm a bit confused about this.

Milker.
« Last Edit: September 26, 2007, 11:01:48 PM by milker »
mid-dec: stupid ass
mid-jan: seroconversion
mid-feb: poz
mar 07: cd4 432 (35%) vl 54000
may 07: cd4 399 (28%) vl 27760
jul 07: cd4 403 (26%) vl 99241
oct 07: cd4 353 (24%) vl 29993
jan 08: cd4 332 (26%) vl 33308
mar 08: cd4 392 (23%) vl 75548
jun 08: cd4 325 (27%) vl 45880
oct 08: cd4 197 (20%) vl 154000 <== aids diagnosis
nov 2 08 start Atripla
nov 30 08: cd4 478 (23%) vl 1880 !!!!!!!!!!!!!!!!!!!!!!!!!!
feb 19 09: cd4 398 (24%) vl 430 getting there!
apr 23 09: cd4 604 (29%) vl 50 woohoo :D :D
jul 30 09: cd4 512 (29%) vl undetectable :D :D
may 27 10: cd4 655 (32%) vl undetectable :D :D

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