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Author Topic: HIV Canít Hide From Specially Engineered CD8 Cells  (Read 3602 times)

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HIV Canít Hide From Specially Engineered CD8 Cells
« on: November 11, 2008, 03:44:03 PM »
Specially engineered ďkillerĒ CD8 cells, modified to more easily recognize and bind to HIV-infected cells, were more effective in the laboratory at controlling HIV reproduction than CD8 cells typically found in the human body, according to a press release detailing a new online report published November 9 by Nature Medicine.

CD4 cellsóHIVís primary target in the human bodyóhave the ability to alert other immune system cells, including CD8s, when they have become infected with the virus. CD4s do this by displaying small chunks of viral proteins on their surfaces. When the receptors on CD8 cells come into contact with these viral proteins, they recognize them as foreign to the body and act to kill the infected cell. Unfortunately, HIV is able to evade this defense because it mutates so rapidly.

James Riley, PhD, from the University of Pennsylvania, and his colleagues in Philadelphia and at Cardiff University in Wales were able to isolate a group of CD8-cell genes that make receptors that are 450 times more sensitive to HIV-infected cells than normal CD8 cell receptors. Rileyís team genetically engineered a population of CD8 cells to produce these more powerful receptors and then placed them in a cell culture along with HIV.

ďNot only could [CD8] cells be engineered to express the strongly binding [CD8]-cell receptor to see HIV strains that had escaped detection by natural [CD8] cells,Ē Riley said, ďbut the engineered [CD8] cells responded in a much more vigorous fashion so that far fewer [CD8] cells were required to control infection.Ē

Riley and his colleagues hope to begin clinical trials next year in HIV-positive patients who are heavily treatment experienced, potentially followed by trials in people recently infected with HIV. The primary aim of the early trials will be to ensure the safety of the engineered CD8 cells and to determine how many a person may need to control HIV reproduction.

Atheist don't believe in GOD, but GOD believes in them and loves them. Never let the failure of man conflict with your love of GOD.

Offline fortuneseeker

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Re: HIV Canít Hide From Specially Engineered CD8 Cells
« Reply #1 on: November 12, 2008, 05:06:53 PM »
This perhaps can be more good than hart ?..

Like a cure even?
something that hunt the virus and kill it?

Offline Peter Staley

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Offline leit

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Re: HIV Can’t Hide From Specially Engineered CD8 Cells
« Reply #3 on: November 13, 2008, 06:37:57 PM »

Your post, although in a quite different way, concerns the same news as "Souped-up immune cells catch disguised HIV"!
Because research news is already a mess (due to "emotional" subjects, too), I think you might want to ask our precious Ann for merging the threads.

Offline messer

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Re: HIV Canít Hide From Specially Engineered CD8 Cells
« Reply #4 on: November 17, 2008, 05:23:23 PM »
Adaptimmune LLC, owns the technology for this advancement.   They responded to an email I sent, that the first small clinical trial is expected to commence in August 2009.     

Offline hahaha

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Re: HIV Canít Hide From Specially Engineered CD8 Cells
« Reply #6 on: December 30, 2008, 09:23:57 PM »
Did they have a clinical trial outside USA? I would think about a phase III trial for this one.
God, let me get out of those poisonous pills....
Aug 9, 2006 Get infected in Japan #$%^*
Oct 2006 CD4 239
Nov 2006 CD4 299 VL 60,000
Dec 1, Sustiva, Ziagan and 3TC
Jan 07, CD4 400

Offline Miss Philicia

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Re: HIV Canít Hide From Specially Engineered CD8 Cells
« Reply #7 on: December 30, 2008, 09:28:58 PM »
I've never heard of poison that keeps people alive.
"Iíve slept with enough men to know that Iím not gay"


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