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Author Topic: Improving Entry Inhibitors...  (Read 1667 times)

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Offline JPinLA

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  • Posts: 148
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Improving Entry Inhibitors...
« on: August 07, 2007, 03:43:42 PM »
I was reading through some papers today and came across this one in PNAS from a group at Trimeris: 

http://www.pnas.org/cgi/content/full/104/31/12772   

Very early development work in improving fusion inhibitors (like Fuzeon) with more potent forms of the peptides.  At least in vitro   they seem to work with virus that has developed resistance to other therapies and that resistance to the new forms of the peptides requires a lot more mutations for decreased sensitivity - again in vitro

Looks like they are in early preclinical testing but they do look promising for enahnced therapeutics down the line and are strong candidates for clinical developement. 

Some good basic science here on HIV drug development research.  We'll see how it pans out.  Not sure what the success/failure has been with Fuzeon but the basic principle of the therapeutis seems very attractive.

JP

 
11/06 - Diagnosed - VL/5784 & CD4 326
2/07 - VL/6000 & CD4 290 2/07
3//07 -Began Truvada/Viramune 
4/07 VL/undetectable and CD4 320 22%
7/07 VL/undetectable and CD4 286 22%
11/07 VL/undetectable and CD4 302 26%

 


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