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Author Topic: 5 Mutations????  (Read 1764 times)

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Offline ALH300

  • Member
  • Posts: 69
  • Some days ur the bug other days ur the windshield!
5 Mutations????
« on: August 01, 2007, 01:54:13 PM »
I was infected in November of 2006, my first labs show that I already have 5 mutations! Is that good? bad? I guess I am not sure what to think of this. I show no signs of resistance on the resistance test.  Any thoughts??
Poz 7-27-07 
First Labs:
07/13/2007 "Friday the 13th" What was I thinking???
314 CD4 17% 9410 VL
10/03/2007
479 CD4 18% 8220 VL
01/03/2008
493 CD4 22.5 % 5900 VL
03/18/2008
432 CD4 14.4 % 11,830 VL
05/06/2008
480 CD4 15.0% 2630 VL
07/16/2008
361 CD4 16.4% 12,830 VL
10/31/2008
362 CD4 15.5% 2500 VL
Started Atripla 11-17-2008
1/16/2009
395 CD4 20.5% undect. VL
5/05/2009
426 CD4 20.3% undect. VL
9/15/2009
422 CD4 22.2% undect. VL

Offline milker

  • Member
  • Posts: 4,034
  • Protected phone sex
Re: 5 Mutations????
« Reply #1 on: August 01, 2007, 01:57:09 PM »
It's fine, mutations do not always equal danger, many mutations are harmless, they are changes in the structure of the virus, but non-functional. If the resistance test says that everything is okay, then everything is okay.

Milker (who has about 20 mutants).
mid-dec: stupid ass
mid-jan: seroconversion
mid-feb: poz
mar 07: cd4 432 (35%) vl 54000
may 07: cd4 399 (28%) vl 27760
jul 07: cd4 403 (26%) vl 99241
oct 07: cd4 353 (24%) vl 29993
jan 08: cd4 332 (26%) vl 33308
mar 08: cd4 392 (23%) vl 75548
jun 08: cd4 325 (27%) vl 45880
oct 08: cd4 197 (20%) vl 154000 <== aids diagnosis
nov 2 08 start Atripla
nov 30 08: cd4 478 (23%) vl 1880 !!!!!!!!!!!!!!!!!!!!!!!!!!
feb 19 09: cd4 398 (24%) vl 430 getting there!
apr 23 09: cd4 604 (29%) vl 50 woohoo :D :D
jul 30 09: cd4 512 (29%) vl undetectable :D :D
may 27 10: cd4 655 (32%) vl undetectable :D :D

Now accepting applications from blowjob ninjas

Offline Miss Philicia

  • Member
  • Posts: 23,565
  • celebrity poster, faker & poser
Re: 5 Mutations????
« Reply #2 on: August 01, 2007, 02:06:23 PM »
My last resistance test which is 2.5 years old now shows 20 mutations.  Every single PI shows reduced susceptibility as do four NRTI's, many wildly so. :(
"Ive slept with enough men to know that Im not gay"

Offline JamieD

  • Member
  • Posts: 259
Re: 5 Mutations????
« Reply #3 on: August 01, 2007, 02:06:52 PM »
Some mutations are associated with a less fit virus, one that is less capable of replicating.

Offline Blixer

  • Member
  • Posts: 712
Re: 5 Mutations????
« Reply #4 on: August 01, 2007, 09:23:24 PM »
It isn't uncommon to have some minor mutations.  Like others have mentioned, HIV is not the best at replicating itself.  It is not unusual for it to develop mutations.  Some make it less effective at doing what it wants to do.  And then every now and then there will be a mutation that keeps a med from being as effective.  It is my understanding that is one reason to be adherent to the meds.  Keeping the viral replication low or nearly zero lessens the chance that a new mutation will develop.  When I had my first and only resistance test my doctor told me that minor mutations are fairly common and nothing to worry about at all.  Your doctor (or the lab report) will tell you if any of the mutations make the virus less susceptible to some of the meds.  So no need to panic at all....
David
Diagnosed 1/9/06
8/27/2007 CD4 598, 29%, VL 58 (72 wks)
11/19/2007 CD4 609, 30%, VL < 50 (84 wks)
2/11/2008 CD4 439, 27%, VL <50 (96 wks)
5/5/2008 CD4 535, 28%, VL <50 (108 wks)
10/20/2008 CD4 680, 28%, VL <50 (132 wks)
Changed to Atripla in 2012
1/14/2013 CD4 855, 35%, VL <40

Offline blondbeauty

  • Member
  • Posts: 1,785
Re: 5 Mutations????
« Reply #5 on: August 02, 2007, 10:58:10 AM »
I dont know how many mutations do I have...But who cares as long as the meds work?
The only member in these forums approved by WINBA: World International Nail and Beauty Association.
Epstein Barr +; CMV +; Toxoplasmosis +; HIV-1 +.
Counts when starting treatment:
V.L.:80.200 copies. CD4: 25%=503
Started Sustiva-Truvada 14/August/2006
Last V.L.count (Oct 2013): Undetectable
Last CD4 count (OCT 2013): 52%= 933

Offline Miss Philicia

  • Member
  • Posts: 23,565
  • celebrity poster, faker & poser
Re: 5 Mutations????
« Reply #6 on: August 02, 2007, 11:26:19 AM »
I dont know how many mutations do I have...But who cares as long as the meds work?

Uh, because people like knowing what their treatment options are?
"Ive slept with enough men to know that Im not gay"

 


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