Quantcast

Subscribe to:
POZ magazine
E-newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join
Username:
Password:
Welcome, Guest. Please login or register.
August 27, 2014, 03:57:17 PM

Login with username, password and session length


Members
Stats
  • Total Posts: 636342
  • Total Topics: 48292
  • Online Today: 204
  • Online Ever: 585
  • (January 07, 2014, 02:31:47 PM)
Users Online

Welcome


Welcome to the POZ/AIDSmeds Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ/AIDSmeds community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Diet High in Saturated Fat May Reduce Protective Effect of HDL  (Read 1773 times)

0 Members and 1 Guest are viewing this topic.

Offline J.R.E.

  • Member
  • Posts: 7,120
  • Joined Dec-2003 Living positive, since 1985.
Hello All !,

Read the following from Medscape ( release date August 7th. I found it interesting, since all this mention of cholesterol lately:

August 7, 2006 The anti-inflammatory activity of HDL appears to decrease after consumption of saturated fat, but improves on consumption of polyunsaturated fat, a new study shows. The findings imply that the cardioprotective effects of HDL may depend not only on HDL level, but also on its behavior in the body in response to meals or other stimuli.

"This is the first demonstration that the quality of HDL can be changed by what you eat," senior author on the study, David S Celermajer, MBBS, PhD, explained in an interview with heartwire. "Eating alters the amount and behavior of cholesterol and its subfractions. What we're saying is that it's not just the amount of HDL, it's how active it is, or how good it is. And its 'goodness' can be profoundly influenced by either a diet high in polyunsaturated fat, or in saturated fat."

The study, led by Stephen J Nicholls, MBBS, PhD, at the Cleveland Clinic in Cleveland, Ohio, appears in the July 21, 2006, JACC Online issue and will appear in the August 15, 2006, print issue of the Journal of the American College of Cardiology.

Good Cholesterol, for Better or Worse
For the study, 14 adults consumed a meal rich in saturated or polyunsaturated fat, followed by a second meal, 1 month later, rich in the alternate type of fat than the type they would have eaten during the earlier meal. Both meals were identical a slice of carrot cake and a milkshake except that one was prepared with safflower oil (a polyunsaturated fat) and the other with coconut oil (a saturated fat). All meals were prepared in such a way that each volunteer consumed 1 g of fat per kilogram of body weight.

Nicholls and colleagues report that levels of plasma triglycerides, insulin, and nonesterfied fatty acids rose after both meals, but the HDL collected 6 hours after the saturated fat meal was accompanied by a higher level of endothelial cell expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1, both markers of inflammation. HDL collected after the polyunsaturated fat meal, by contrast, had significantly lower expression of both molecules. Inflammation of endothelial cells is believed to be an important process in the development of atherosclerosis, Celermajer told heartwire, while HDL is hypothesized to play a role in modulating inflammation in the endothelium. As a secondary finding in the study, the authors report that microvascular flow was also increased to a greater degree in adults who had eaten the polyunsaturated diet, while flow mediated dilation was decreased to a greater degree following the saturated meal.

Of note, the volunteers in the study by Nicholls and colleagues were between the ages of 18 and 40 years with no existing cardiovascular disease. Whether similar results would be seen in subjects with atherosclerosis or other risk factors are unknown, the authors point out.

Future Directions
The possibility of modifying HDL behavior should reinvigorate the field of HDL research, Dr. Celermajer says. "Now that we've established that the good cholesterol is not a fixed thing, it's a dynamic thing, it opens up a whole new area of study of what can influence the quality of HDL. Will different kinds of exercise make your HDL more protective, what is the best diet for your HDL, what do certain medications that we use frequently do to your HDL?"

Dr. Celermajer also suggests that ongoing research should evaluate HDL behavior when meals are being digested.

"Almost all of the studies of cholesterol and fats are done in people after an overnight fast. Those of us who live in countries like the US or Australia spend about half our lives in the post-absorptive state the three or four hours after we've eaten something. What this work highlights is that to understand the relationship between cholesterol and heart health better, we need to start to look at what cholesterol looks like, not just after an overnight fast, but after we eat."

J Am Coll Cardiol. 2006;48:715-720.

Published online August 8, 2006.


To view this article or other articles through Medscape, you will have to sign up :

https://profreg.medscape.com/px/getlogin.do;jsessionid=GpLbBG8HmvC8lvRnBxVzvFBnyq1VbYLDX4yyQGBh0G5Kt9xtwZPY!1736076153?urlCache=aHR0cDovL3d3dy5tZWRzY2FwZS5jb20vdmlld2FydGljbGUvNTQyMzk3P3Nzc2RtaD1kbTEuMjA3MTg4JnNyYz1ubGRuZQ==





Ray


« Last Edit: August 13, 2006, 02:56:44 AM by J.R.E. »
Current Meds ; Viramune, Epzicom, 40mg of simvastatin, 12.5mg of Hydrochlorothiazide.
Metoprolol tartrate 25mg



http://forums.poz.com/index.php?topic=40802.0

http://forums.poz.com/index.php?topic=45159.0

http://forums.poz.com/index.php?topic=39722.msg495621;topicseen#msg495621

http://forums.poz.com/index.php?topic=46806.0

http://forums.poz.com/index.php?topic=39414.msg491701#msg491701


 In October of 2003, My t-cell count was 16, Viral load was over 500,000, Percentage at that time was 5%. I started my first  HAART regimen  on October 24th,03.

 As of 6/4/14,  t-cells are at 423, Viral load <40

 Current % is at 13% 

  
 62 years young.

Offline alisenjafi

  • Member
  • Posts: 811
  • They say HIV comes from monkeys!
Re: Diet High in Saturated Fat May Reduce Protective Effect of HDL
« Reply #1 on: August 13, 2006, 09:48:14 AM »
Hey brother Ray- I am seeing a nutritionist in a few weeks so I will take along the article as well as the GALT one, and see if there is any practical use of this info.
Cheers
Johnny
"You shut your mouth
how can you say
I go about things the wrong way
I am human and I need to be loved
just like everybody else does"
The Smiths

 


Terms of Membership for these forums
 

© 2014 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.