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Author Topic: Potential cure for HIV discovered  (Read 2105 times)

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Offline orishaspollo

  • Member
  • Posts: 43
Potential cure for HIV discovered
« on: July 09, 2007, 11:49:44 AM »


n a breakthrough that could potentially lead to a cure for HIV infection, scientists have discovered a way to remove the virus from infected cells, a study released this week said.

The scientists engineered an enzyme which attacks the DNA of the HIV virus and cuts it out of the infected cell, according to the study published in Science magazine.

The enzyme is still far from being ready to use as a treatment, the authors warned, but it offers a glimmer of hope for the more than 40 million people infected worldwide.

"A customized enzyme that effectively excises integrated HIV-1 from infected cells in vitro might one day help to eradicate (the) virus from AIDS patients," Alan Engelman, of Harvard Universityís Dana-Farber Cancer Institute, wrote in an article accompanying the study.

Current treatments focus on suppressing the HIV virus in order to delay the onset of AIDS and dramatically extend the life of infected patients.

What makes HIV so deadly, however, is its ability to insert itself into the bodyís cells and force those cells to produce new infection.

"Consequently the virus becomes inextricably linked to the host, making it virtually impossible to ícureí AIDS patients of their HIV-1 infection," Engelman explained.

That could change if the enzyme developed by a group of German scientists can be made safe to use on people.

That enzyme was able to eliminate the HIV virus from infected human cells in about three months in the laboratory.

The researchers engineered an enzyme called Tre which removes the virus from the genome of infected cells by recognizing and then recombining the structure of the virusís DNA.

This ability to recognize HIVís DNA might one day help overcome one of the biggest obstacles to finding a cure: the ability of the HIV virus to avoid detection by reverting to a resting state within infected cells which then cease to produce the virus for months or even years.

"Numerous attempts have been made to activate these cells, with the hope that such strategies would sensitize the accompanying viruses to antiviral drugs, leading to virus eradication," Engelman wrote. "Advances with such approaches in patients have been slow to materialize."

New experiments must be designed to see if the Tre enzyme can be used to recognize these dormant infected cells, he wrote.

"Although favorable results would represent perhaps only a baby step toward eventual use in patients, the discovery of the Tre recombinase proves that enzymatic removal of integrated HIV-1 from human chromosomes is a current-day reality," he said.

The researchers who developed the enzyme were optimistic about their ability to design additional enzymes which would target other parts of the virusís DNA.

However they warned that there were significant barriers to overcome before the enzyme could be used to help cure patients.

"The most important, and likely most difficult, among these is that the enzyme would need efficient and safe means of delivery and would have to be able to function without adverse side effects," wrote lead author Indrani Sarkar of the Max Planck Institute for Molecular Cell Biology and Genetics in Dresden.

"Nevertheless the results we present offer an early proof of principal for this type of approach, which we speculate might form a useful basis for the development of future HIV therapies," Sarkar concluded.

I just wanted to know what are the thoughts of this post

Offline RapidRod

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  • Posts: 15,288
Re: Potential cure for HIV discovered
« Reply #1 on: July 09, 2007, 12:33:18 PM »
Shouldn't this have been posted in the research forum?

Offline redhotmuslbear

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  • Posts: 605
  • A genuine certified freak of nature, and a hot one
Re: Potential cure for HIV discovered
« Reply #2 on: July 09, 2007, 01:10:34 PM »
This same piece was posted two weeks ago in the research forum.  It's a good example of breathless hype and reporting.
"The real problem is not whether machines think but whether men do." - BF Skinner
12-31-09   222wks VL  2430 CD4 690 (37%)
09-30-09   208wks VL  2050  CD4 925 (42%)
06-25-08   143wks VL  1359  CD4 668 (32%)  CD8 885
02-11-08   123wks off meds:  VL 1364 CD4 892(40%/0.99 ratio)
10-19-07   112wks off meds:   VL 292  CD4 857(37%/0.85 ratio)

One copy of delta-32 for f*****d up CCR5 receptors, and an HLA B44+ allele for "CD8-mediated immunity"... beteer than winning Powerball, almost!

Offline Cerrid

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  • Posts: 499
  • only as good as your last haircut
Re: Potential cure for HIV discovered
« Reply #3 on: July 09, 2007, 02:23:21 PM »
Just the usual summer hole media hype. However, I wouldn't be surprised if headlines like this let the infection rates rise... "Oh, there's a cure? Great, let's go raw!"  :(
"Boredom is always counterrevolutionary. Always." (Guy Debord)

Offline Iggy

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  • Posts: 2,435
Re: Potential cure for HIV discovered
« Reply #4 on: July 09, 2007, 02:33:40 PM »
my thoughts on this are best summed up by a quote in the article itself:

Quote
This ability to recognize HIVís DNA might one day

Let me know when it's a definite and the day is actually here.

Offline Queen Tokelove

  • Member
  • Posts: 6,033
  • Smokey the Smurf
Re: Potential cure for HIV discovered
« Reply #5 on: July 09, 2007, 03:36:01 PM »
I'm tired of maybe there will be a cure.....I don't think I'll see it in my life time...
Started Atripla/Ziagen on 9/13/07.
10/31/07 CD4-265 VL- undetectable
2/6/08 CD4- 401 VL- undetectable
5/7/08 CD4- 705 VL- undetectable
6/4/08 CD4- 775 VL- undetectable
8/6/08 CD4- 805 VL- undetectable
11/13/08 CD4- 774 VL--undetectable
2/4/09  CD4- 484  VL- 18,000 (2 months off meds)
3/3/09---Starting Back on Meds---
4/27/09 CD4- 664 VL-- undetectable
6/17/09 CD4- 438 VL- 439
8/09 CD4- 404 VL- 1,600
01-22-10-- CD4- 525 VL- 59,000
Cherish the simple things life has to offer

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Offline Miss Philicia

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  • Posts: 24,111
  • celebrity poster, faker & poser
Re: Potential cure for HIV discovered
« Reply #6 on: July 09, 2007, 03:48:23 PM »
Q:  How many times have I read this same headline in the past 15 years?
"Iíve slept with enough men to know that Iím not gay"

Offline Dachshund

  • Member
  • Posts: 5,959
Re: Potential cure for HIV discovered
« Reply #7 on: July 09, 2007, 04:34:04 PM »
Orishaspollo the living with forums are for HIV+ people only and you should not be posting here. Please read the welcome thread.

 


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