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Author Topic: A cure within 10 years? German Breakthrough!  (Read 4418 times)

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Offline zeb

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A cure within 10 years? German Breakthrough!
« on: June 29, 2007, 05:33:28 AM »
This is not a 'Gambian Banana Story'

Though the claim is brought with some caution, German scientists expect to have a cure within 10 years from now.

They have published results of their breaking biotechnoligical research in Science Magazine. The Germans have found a way to 'cut out' the genes of the hiv virus from infected cells. In this way they are able to cure the cells.

I haven't found an English article yet. But here's a link to a Dutch newspaper:
http://www.ad.nl/diagnose/article1470769.ece

greets,
Zeb
« Last Edit: June 29, 2007, 05:36:51 AM by zeb »

Offline ARMANDO

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Re: A cure within 10 years? German Breakthrough!
« Reply #1 on: June 29, 2007, 07:54:06 AM »
THATS WHAT THEY SAID 10 YEARS AGO!!! >:( :o

Offline Cerrid

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  • only as good as your last haircut
Re: A cure within 10 years? German Breakthrough!
« Reply #2 on: June 29, 2007, 08:25:07 AM »
I haven't found an English article yet. But here's a link to a Dutch newspaper:
http://www.ad.nl/diagnose/article1470769.ece

Look here, Research News. :)
"Boredom is always counterrevolutionary. Always." (Guy Debord)

Offline bear60

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Re: A cure within 10 years? German Breakthrough!
« Reply #3 on: June 29, 2007, 12:38:29 PM »
I think posting this in TREATMENT is a big mistake.
Poz Bear Type in Philadelphia

Offline leatherman

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Re: A cure within 10 years? German Breakthrough!
« Reply #4 on: June 29, 2007, 02:07:04 PM »
i agree with Bear. this is definitely an item for the "research" forum as they aren't claiming a treatment or a side effect (which is the title of this forum) - just the hope of being able to develop this into "something" "sometime" in the future.

quote from http://forums.poz.com/index.php?topic=13476.0
Quote
However, it is still a long way until this approach can be used in clinical practice. “We will first go back to the bench to further improve the enzyme and then test whether the recombinase can be delivered efficiently and safely to cells in the human body”, said Buchholz and Hauber.
leatherman (aka mIkIE)


chart from 1992-2013; updated 2/09/13  Reyataz/Norvir/Truvada

Offline bimazek

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Re: A cure within 10 years? German Breakthrough!
« Reply #5 on: June 30, 2007, 02:07:30 AM »
here is my take on it-- they give you this new med say in 10 years they hope to have it out, ok you take it for three months and the virus is eliminated, then if there is one or two dna strands somewhere still there somewhere it may take months or years then the viral load creeps up or there is a sero convert event and then you have to go back on meds, for 3 months, kind of like herpes or shingles or something... that is worst case in my hopes...

after thinking aobut this over night seems like the period without any problems after the 3 month treatment could be many months or even years, why, because a few strands of dna in a few cells might take a long long time to be activated (it is not like a primary infection where the virus is out side the cell- the dna is deep in the dna and only gets reproduced if the cell is activated)  seems like there could be years of med free existance


http://www.theaustralian.news.com.au/story/0,20867,21992355-2702,00.html

In the German experiments, the enzyme recognised sections of infected cell DNA as belonging to HIV, and cut it out. The enzyme, Tre recombinase, eliminated the virus from the infected cells in about three months.
« Last Edit: June 30, 2007, 01:29:55 PM by bimazek »

Offline hahaha

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Re: A cure within 10 years? German Breakthrough!
« Reply #6 on: June 30, 2007, 09:27:06 AM »
bimazek's concern do have a point.  However, I believe there must be some "cocktail" and put HAART+ recombizyne + preventive vaccine + PD-1 or whatever to work out for eradication.

 
Aug 9, 2006 Get infected in Japan #$%^*
Oct 2006 CD4 239
Nov 2006 CD4 299 VL 60,000
Dec 1, Sustiva, Ziagan and 3TC
Jan 07, CD4 400

Offline bimazek

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Re: A cure within 10 years? German Breakthrough!
« Reply #7 on: June 30, 2007, 01:31:54 PM »


this is the best detailed science description i have found on this, perhaps milker can shed some light on all this

the bacterial enzyme Cre recombinase, which exchanges any two pieces of DNA flanked on either end by a certain pattern of nucleotides (DNA subunits) known as loxP.  HIV does not naturally contain loxP sites, so the team created a hybrid of the two DNA molecules, which they used to select a series of mutated Cre enzymes that were increasingly able to recognize the combined DNA. The final enzyme, Tre, removed all traces of HIV from cultured human cervical cells after about three months, the researchers report online today in Science.

http://forums.poz.com/index.php?action=post;topic=13483.0;num_replies=6


 


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