Meds, Mind, Body & Benefits > Questions About Treatment & Side Effects

Drug interactions with Zofran for nausea

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The effect on the PN pain was immediate and is still apparent.  I am taking far fewer opiates for my pain control than before.  I have done a little search of the literature and it is known that 5-HT3 receptors (at which ondansetron is an antagonist) are known to be involved in spinal nociceptive (pain retransmission) mechanisms.  One paper of particular interest can be found at the following website and I suggest that you read the abstract at least:  There are a number of other references on the subject and another interesting one can be viewed at:

Thanks for your interest!

Incidentally, I have myself published several papers on ondansetron and other 5-HT3 drugs and had hoped that the drug company might feel inclined to provide me with the stuff for free.  The cost through my insurance is $3,000 per month, but some Canadian pharmacies are a whole lot more dollar-friendly if anyone needs to know.


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