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Author Topic: Commercial Genetic test for slow progression  (Read 1888 times)

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Offline NYCguy

  • Member
  • Posts: 180
Commercial Genetic test for slow progression
« on: June 05, 2007, 04:20:28 PM »
Fee like I read something about this a while ago.  I have to admit, it sounds a little like a money-making scheme, since the test doesn't really have any impact on treatment.  Anyone else heard about this or have thoughts on it?

http://www.medindia.net/news/HIVmirror-LLC-Launching-Breakthrough-Genetic-Product-for-HIV-Positive-Consumer-21679-1.htm

HIVmirror, LLC Launching Breakthrough Genetic Product for HIV Positive Consumer
 
PHILADELPHIA, HIVmirror LLC, a Philadelphia-based company offering HIV positive consumers the latest in confidential DNA testing, is announcing the launch of their innovative HIV progression test, HIVmirror(TM). This affordable, easy-to-use product, with its user-friendly Web site (http:www.hivmirror.com), empowers modern consumers and gives a unique insight into their genetic code and its role in their potential HIV disease progression. 


HIVmirror(TM) is a revolutionary scientific test that assesses an individual's DNA for CCR5-Delta32 (known as Delta 32) and CCR2-64I, two genetic variations that are known for slowing the process in which HIV becomes AIDS. HIVmirror(TM) is available for consumer use in the privacy of their own home with easy-to-use instructions and confidential results. Until now, this test was only available to participants in formal research studies.

According to the results shows the information about how a person's genes may effect HIV disease progression and more specifically, if their gene types are associated with slowing the progression of HIV infection to AIDS. This can provide insight to how their body is reacting to HIV and simply offer a peace of mind.

HIVmirror(TM) is based on published NIH funded studies that made associations between genetic variations and the course of HIV-1 infection. Scientists studied over 4000 people with HIV-1 infection observing who developed AIDS. Participants underwent special genetic testing determining if they carried the CCR5-Delta32 or the CCR2 64I genetic variations that are suspected to affect the progression of HIV.
 
11/9/06 = #$%^&!
sometime early Dec 2006:
CD4 530 20%/VL >250,000 (&*$$%!!)
started Reyataz300mg/Norvir/Truvada 12-27-06.
1/30/07 CD4 540 30%/VL <400
4/07 CD4 600+ 33%/VL <50
6/9/07 CD4 720 37%/VL <50
10/15/07 CD4 891 (!) %? VL <50
1/2010 CD4 599 (37%) VL<50 (drop due to acute HCV)
9/2010 - looks like HCV is gone for good! And I'm finally drinking again, thank GOD
2013 - considering a switch to Stribild. but I love my Kidneys (but I hate farting all the time!)...
June 2013 - switched to Stribild.  so far so good...

Offline Central79

  • Member
  • Posts: 527
Re: Commercial Genetic test for slow progression
« Reply #1 on: June 13, 2007, 05:49:15 AM »
I think there are so many factors that influence disease progression. CCR5 deletions are an important one, but by no means the only one or even a factor that accounts for the majority of variability seen between different people.

There's something about human beings that loves taking a test, that might explain or reassure. I've thought about it - because, just like when I get a good CD4 result, this too might make me feel better about the future. It's like those people who pay for private CT scans periodically - it's reassuring to know you don't have any huge cancers anywhere!

But like you said, it's not really going to inform treatment, it's just marketed to that most universal human attribute: hope. As such, it's pretty clever.

Matt

(who doesn't have a spare 50 quid)
Diagnosed January 2006
26/1/06 - 860 (22%), VL > 500,000
24/4/06 - 820 (24.6%), VL 158,000
13/7/06 - 840 (22%), VL 268,000
1/11/06 - 680 (21%), VL 93,100
29/1/07 - 1,020 (27.5%), VL 46,500
15/5/07 - 1,140 (22.8%), VL not done.
13/10/07 - 759 (23.2%), VL 170,000
6/11/07 - 630 (25%), VL 19,324
14/1/08 - 650 (21%), VL 16,192
15/4/08 - 590 (21%), VL 40, 832

Offline redhotmuslbear

  • Member
  • Posts: 605
  • A genuine certified freak of nature, and a hot one
Re: Commercial Genetic test for slow progression
« Reply #2 on: June 30, 2007, 11:05:49 AM »
For those with an interest in genetic geneology, I found that Family Tree DNA offers a CCR5 delta-32 test for only USD20 if one has an extracted sample with them or adds the test to a new order for Y-DNA and mitochondrial RNA profiling.  I have been using FTDNA to extend my known family history to the 1740s on North America, by connecting with men who exactly match a certain number of Y alleles, including another Gay man who shares our 8th-great-grandfather....and the resemblance between us is freaky.

So, sure, in total the testing would be more than HIV mirror..and it's not going to produce impactful data for most people.... but if you're a non-progressor who's never had the test or someone with an interest in ancestry, it may be worth the expense.

Cheers,
David
"The real problem is not whether machines think but whether men do." - BF Skinner
12-31-09   222wks VL  2430 CD4 690 (37%)
09-30-09   208wks VL  2050  CD4 925 (42%)
06-25-08   143wks VL  1359  CD4 668 (32%)  CD8 885
02-11-08   123wks off meds:  VL 1364 CD4 892(40%/0.99 ratio)
10-19-07   112wks off meds:   VL 292  CD4 857(37%/0.85 ratio)

One copy of delta-32 for f*****d up CCR5 receptors, and an HLA B44+ allele for "CD8-mediated immunity"... beteer than winning Powerball, almost!

 


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