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Author Topic: What is your mood about future drugs?  (Read 4777 times)

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Offline dario

  • Member
  • Posts: 80
What is your mood about future drugs?
« on: June 23, 2006, 01:38:57 PM »
I once said to my doctor: "you suggest me the right drugs to keep me alive for the next 10 years.  Meanwhile scientists and reasearches would have found a cure to clear the bug from all of us."  He just smiled and replied diplomatically: "it is not entirely impossible." 

I am asking this question because I am very new to this scene.  I've read and read many articles on the web. I guess many of you experienced this phase ....  Of course many sites on the web are pure trash (for example finding a 'cure' from frog skin toxins etc).  So I obviously prefer the professional sites (universities) and journals (journal of virology etc).  Then there are other sites like The Body and those of the pharmaceutical industry.

My doctor is cautiously optimistic.  BUT THIS TIME I WANT TO LEARN FROM POZ PEOPLE.  What is your mood? 
... when I was young, I never needed anyone, making love was just for fun, those days are gone ... Eric Carmen (Raspberries)

Offline john

  • Member
  • Posts: 21
Re: What is your mood about future drugs?
« Reply #1 on: June 23, 2006, 01:58:15 PM »

 Keep in mind I am newly diagnosed and  new to this club. However I cant help but believe with the new classes of drugs (Integrase, maturation inhibitors, Entry inhibitors) and the pipeline of new existing drugs. New cocktails will be more potent and less prone to resistance than previous regimens. Obviously I have no proof but I do believe this in my heart. Sooner or later Science will find the magic bullet that will cure or continually keep this virus at bay. In closing I am looking forward to watching all the new cocktails and improving numbers from all the fantastic people here.

                          John (soon to be over 200t) I hope....
Jon be good

Offline jkinatl2

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  • Posts: 6,007
  • Doo. Dah. Dipp-ity.
Re: What is your mood about future drugs?
« Reply #2 on: June 23, 2006, 06:45:46 PM »
I am optimistic. New drugs, and refined versions of older drugs are coming out each year. There are enough classes of drugs in enough combinations on the market today to keep someone going for a decade or more before s/he runs through resistance, and that's if they are among the minority that develops resistance 18 months into every regiman (not easy to do, unless you are consistently non-adherent).

Not that you ought to take that as permission to fly through whole classes of drugs. If you commit to them, it's important to take your regimen every day, on time. They really are quite demanding (and in many cases, unforgiving). But there are many people on this site who have been on drug therapy for ten, fifteen, twenty years and more.

I'm one of them, and my adherence has been for crap. I am currently not on meds, but am keeping a lookout for some of the newer blips on the horizon. I imagine I will probably be back on something by this time next year, if not earlier.

I tested positive in 1993. Developed PCP by 1994, and was put on AZT monotherapy. Seriously, we have come SO far since then. We have not had another real breakthrough like the protease inhibitors in 1996, but we continue to make incremental progress - and the Next Big Thing could be right around the bend.

Hang in there. Ten years? Try thirty.

And THAT's without knowing the future :)

"Many people, especially in the gay community, turn to oral sex as a safer alternative in the age of AIDS. And with HIV rates rising, people need to remember that oral sex is safer sex. It's a reasonable alternative."

-Kimberly Page-Shafer, PhD, MPH

Welcome Thread

Offline dario

  • Member
  • Posts: 80
Re: What is your mood about future drugs?
« Reply #3 on: June 23, 2006, 07:42:20 PM »
Thanks Jonathan. It really helped.  Sometimes I think that my doctor is being optimistic simply to be nice.  Perhaps I am being paranoic.  I have so many questions but I don't know who too ask.  Each time I visit the doctor I bombard him with questions.  Then I search on the net but end up with a headache. 
... when I was young, I never needed anyone, making love was just for fun, those days are gone ... Eric Carmen (Raspberries)

Offline sdcabincrew74

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Re: What is your mood about future drugs?
« Reply #4 on: June 24, 2006, 04:04:36 PM »
My doctor is optomistic about the future, and, to a point, I am too.  Right now I have great cocktail that works for me and I am doing everything possible to make sure it keeps working.  But as with all things in my life, I plan for the worst and hope for the best.  So, my honest opinion is that this is all there will be.
The difference between an overnight and a layover is luck!

Offline blondbeauty

  • Member
  • Posts: 1,785
Re: What is your mood about future drugs?
« Reply #5 on: June 24, 2006, 05:04:25 PM »
I donīt think a "cure" will be found, because all the cells containing HIV should be killed to achieve erradication and that could be very bad, specially for the brain. But I think excellent meds will be available with little side effects and not prone to resistance.
The only member in these forums approved by WINBA: World International Nail and Beauty Association.
Epstein Barr +; CMV +; Toxoplasmosis +; HIV-1 +.
Counts when starting treatment:
V.L.:80.200 copies. CD4: 25%=503
Started Sustiva-Truvada 14/August/2006
Last V.L.count (Oct 2013): Undetectable
Last CD4 count (OCT 2013): 52%= 933

Offline lydgate

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Re: What is your mood about future drugs?
« Reply #6 on: June 24, 2006, 06:47:42 PM »
I'm cautiously optimistic about future drugs as well. And this is even with the not-so-good news about the much-anticipated CCR5 inhibitors. I'm 33; I plan on being around for decades, a lecherous dirty old man, with his Super-Viagra and his rent boys. What makes me sick to my stomach is the thought that more than 90% of HIVers around the world will not have not access to most new drugs. Not unless something changes, dramatically, in treatment access programs. Even in countries where they give free ARVs to everyone who needs them, it's a one-cocktail-fits-all method; and if you fail that regimen, there's no back up unless you can afford to pay for the imported drugs (which about 0.01% can do).

Jonathan, if this isn't prying: what are your numbers? I've been reading about drug holidays and there seems to be an emerging consensus that they might not be such a good idea after all (but of course each individual situation is different). I have a friend who's been off his meds, Sustiva+Combivir, for 9 months, and he wants to go a full year; his latest labs are VL 75K and CD4 290. I'm worried for him, with a CD4 below 300 and a VL that keeps climbing, I don't want him to be "off" his meds for another three months. But he's stubborn. And he plans to run the Chicago marathon in October.
Her finely-touched spirit had still its fine issues, though they were not widely visible. Her full nature, like that river of which Cyrus broke the strength, spent itself in channels which had no great name on the earth. But the effect of her being on those around her was incalculably diffusive: for the growing good of the world is partly dependent on unhistoric acts; and that things are not so ill with you and me as they might have been, is half owing to the number who lived faithfully a hidden life, and rest in unvisited tombs.

George Eliot, Middlemarch, final paragraph

Offline blondbeauty

  • Member
  • Posts: 1,785
Re: What is your mood about future drugs?
« Reply #7 on: June 25, 2006, 05:25:05 AM »
In some places of Africa people not only have no acces to antiretrovirals. Antibiotics for minor infections or even clean drinkable water are not available and cause many deaths. There is so much to do and not only about HIV...
The only member in these forums approved by WINBA: World International Nail and Beauty Association.
Epstein Barr +; CMV +; Toxoplasmosis +; HIV-1 +.
Counts when starting treatment:
V.L.:80.200 copies. CD4: 25%=503
Started Sustiva-Truvada 14/August/2006
Last V.L.count (Oct 2013): Undetectable
Last CD4 count (OCT 2013): 52%= 933

Offline newt

  • Member
  • Posts: 3,887
  • the one and original newt
Re: What is your mood about future drugs?
« Reply #8 on: June 25, 2006, 03:53:30 PM »
I reckon I've done half my life, n plan to pop off at 80, so optimistic

- matt
"The object is to be a well patient, not a good patient"

Offline doyourowndamndishes

  • Member
  • Posts: 85
Re: What is your mood about future drugs?
« Reply #9 on: June 26, 2006, 01:12:56 PM »
Optimistic!  I have been on PI therapy for 5 years and have been very successful with them.  I have had very minimal side effects and nothing too serious that has not already been dealt with.  With the recent announcement of Prezista, that's one more PI I can hopefully be able to use provided I do not develop any resistances to the drug class.  So far, I have a resistance to Nelfinavir but have been able to compensate by boosting regimens.  If I need to make another switch I definitely was not looking forward to having to take Crixivan or Invirase; both drugs have a strong track record with lipo.  Now I have potentially a new drug to consider before leaving the PIs altogether.

Cheers,

Alan
"All that we are is theresult of what we have thought." -Buddha

Offline HIVworker

  • Member
  • Posts: 918
  • HIV researcher
Re: What is your mood about future drugs?
« Reply #10 on: June 28, 2006, 07:52:39 PM »
Can I answer this too?
NB. Any advice about HIV is given in addition to your own medical advice and not intended to replace it. You should never make clinical decisions based on what anyone says on the internet but rather check with your ID doctor first. Discussions from the internet are just that - Discussions. They may give you food for thought, but they should not direct you to do anything but fuel discussion.

Offline The Canuck

  • Member
  • Posts: 628
Re: What is your mood about future drugs?
« Reply #11 on: June 28, 2006, 07:55:12 PM »
Yes  ;)

The Canuck

 


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