Quantcast

Subscribe to:
POZ magazine
E-newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join
Username:
Password:
Welcome, Guest. Please login or register.
September 19, 2014, 02:43:07 AM

Login with username, password and session length


Members
Stats
  • Total Posts: 639360
  • Total Topics: 48532
  • Online Today: 218
  • Online Ever: 585
  • (January 07, 2014, 02:31:47 PM)
Users Online

Welcome


Welcome to the POZ/AIDSmeds Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ/AIDSmeds community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Truvada/ Sustiva vs. Truvada/ Viramune  (Read 7035 times)

0 Members and 1 Guest are viewing this topic.

Offline Joel90069

  • Member
  • Posts: 28
  • "Another turning point a fork stuck in the road."
Truvada/ Sustiva vs. Truvada/ Viramune
« on: June 26, 2006, 02:16:02 PM »
Does anyone know if there is an effectiveness advantage of going with Truvada and Sustiva vs. taking Truvada and Viramune? Why do physicians opt for Sustiva first?

Offline newt

  • Member
  • Posts: 3,885
  • the one and original newt
Re: Truvada/ Sustiva vs. Truvada/ Viramune
« Reply #1 on: June 26, 2006, 04:23:58 PM »
Hello Joel

Until recently, many studies were done using Sustiva, but not Viramune, as first-line therapy, which secured its status as the preferred starter NNRTI.  However, Viramune is an effective drug.  This was confirmed by the NEFA study, which found (in which PI treated patients with viral loads under 200) no difference in effectiveness or discontinuations from side effects between Sustiva and Viramune, and the 2NN study, which found, broadly speaking, Sustiva 1 x day, Viramune 1 x day and Viramune 2 x day to be equally effective (2/3rds of people achieving undetectable viral loads).

UK and US guidelines recommended Sustiva as first choice and Viramune as an alternative. This is largely because of the small risk of serious reactions against Viramune. Plus Viramune is licensed as a 2 x day drug, to be strict about it while Sustiva is licensed for use 1 x day (1 x day being apparently easier for people taking the tabs....). 

Both drugs have some similar side effects. This includes risk of rash and liver toxicity, which can be serious. Careful monitoring should check for this. Sustiva is well known for its head effects (dreams, dizziness, anxiety), which Nevirapine doesn't have (except in a very, very few cases).

In practice, both drugs are used widely, maybe 60% of people using NNRTIs on Sustiva and 40% on Viramune in the UK.

- matt
"The object is to be a well patient, not a good patient"

Offline newt

  • Member
  • Posts: 3,885
  • the one and original newt
Re: Truvada/ Sustiva vs. Truvada/ Viramune
« Reply #2 on: June 26, 2006, 04:30:00 PM »
I see from your other post that you's gone the Sustiva route.  Good luck, the side effects often lessen with time, you'll know sooner or later if it;s for you long-term.  Usually a switch to Viramune is pretty straightforward, but do note that in men with a CD4 count of 400+ the chance of a rash/bad liver reaction is higher, and your CD4 count's edging that way now, so if a change is on the cards a PI may be a better choice.

- matt
"The object is to be a well patient, not a good patient"

Offline Joel90069

  • Member
  • Posts: 28
  • "Another turning point a fork stuck in the road."
Re: Truvada/ Sustiva vs. Truvada/ Viramune
« Reply #3 on: June 26, 2006, 06:56:11 PM »
Thanks for the comprehensive response! I'm leaning toward switching. I'm moody, isolating and having a problem concentrating. Eventually it's going to have an effect on my work performance.

Offline J.R.E.

  • Member
  • Posts: 7,159
  • Joined Dec-2003 Living positive, since 1985.
Re: Truvada/ Sustiva vs. Truvada/ Viramune
« Reply #4 on: June 26, 2006, 08:21:11 PM »
Hello Joel,

 I was started on Viramune ( first time therapy ) back in October of 2003. Still on it. And of course, I don't have any of the vivid dreams or mood swings associated with Sustiva. As far as the Truvada, I am on the Viread component of that. Never done Emtriva.

I also went through the break in period with Viramune, very well, with no problems. I often wonder if my doctor had started me on viramune, due to the fact that I was working full time.



The Best---------Ray
Current Meds ; Viramune, Epzicom, 40mg of simvastatin, 12.5mg of Hydrochlorothiazide.
Metoprolol tartrate 25mg



http://forums.poz.com/index.php?topic=40802.0

http://forums.poz.com/index.php?topic=45159.0

http://forums.poz.com/index.php?topic=39722.msg495621;topicseen#msg495621

http://forums.poz.com/index.php?topic=46806.0

http://forums.poz.com/index.php?topic=39414.msg491701#msg491701


 In October of 2003, My t-cell count was 16, Viral load was over 500,000, Percentage at that time was 5%. I started my first  HAART regimen  on October 24th,03.

 As of 8/2514,  t-cells are at 402, Viral load <40

 Current % is at 11%

  
 62 years young.

Offline Dboy

  • Member
  • Posts: 5
Re: Truvada/ Sustiva vs. Truvada/ Viramune
« Reply #5 on: June 26, 2006, 11:06:16 PM »
I am on the sustiva and truvada regime and went undetectable quickly so this combo is very effective.  My triclyserides have gone up rather high and everything that you have heard about the sustiva head trips are spot on.  This is my third month and the effects have moderated but my doctor is worried about the restless sleep, fatigue and focusing problems that are still with me.  I'm thinking now I should have gone with the viramune instead of sustiva.  Taking the pills just one a day is good but I also take various vitamins and supplements and an allergy pill so one more pill would not be a big thing for me.  Sustiva was first out and has a good track record so that is why it is listed ahead of the viramune.  And viramune does have the allergic reaction potential.
Just my thoughts and experiences.
David

Offline Joel90069

  • Member
  • Posts: 28
  • "Another turning point a fork stuck in the road."
Re: Truvada/ Sustiva vs. Truvada/ Viramune
« Reply #6 on: June 27, 2006, 12:36:32 AM »
Dboy, that's exactly how I feel with Sustiva. Even though I'm undetectable I'm going to take the risk and make the change. Thanks for your input.

 


Terms of Membership for these forums
 

© 2014 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.