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Author Topic: Conflicting Results Resistance Testing  (Read 1570 times)

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Offline FiercenBed

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Conflicting Results Resistance Testing
« on: May 17, 2007, 05:41:06 AM »
on my first resistance test done @ diagnosis iv got 5 mutations. 196E,211K,214F,135T,63P. it shows 'maximal response' to almost all meds and 'susceptible' to 5.

so i hit a vl rebound of almost 5k. so doc orders another resistance test. this time itz a different company; our good friends @ LabCorp. This one comes back w/ just 1 mutation, 63P. doc sez 'itz common & everyone has it". and still 'sensitive' to all drugs......havnt figured that one out yet.

the question here is what happened to the other 4 mutations? itz the other way around....u get more mutations w/ treatment not less right? is this a lab problem or do mutations go away?

Offline allopathicholistic

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Re: Conflicting Results Resistance Testing
« Reply #1 on: May 19, 2007, 08:54:50 AM »
"educational" bump

Offline milker

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Re: Conflicting Results Resistance Testing
« Reply #2 on: May 19, 2007, 11:03:55 AM »
Is it possible that your phenotype was taken within the first 3 months of infection? If so, mutations will disappear in the absence of treatment, just because they're not fit enough. It's Darwin's law :D Some mutations may have been "hiding" too, and not found by the second phenotype.

I checked your mutations, and they come back with this frequency for people not on meds:

196E 4.4%
211K 43%
214F 15%
135T 31%
63P 56%

You can see on here http://hivdb.stanford.edu/pages/barChart_MutPrevBySubtype/PR_untreated.html that 63P is very common for subtype HIV1-B and here http://hivdb.stanford.edu/pages/barChart_MutPrevBySubtype/RT_untreated.html for 211K too.

You have a boring HIV-B virus, my friend :D

mid-dec: stupid ass
mid-jan: seroconversion
mid-feb: poz
mar 07: cd4 432 (35%) vl 54000
may 07: cd4 399 (28%) vl 27760
jul 07: cd4 403 (26%) vl 99241
oct 07: cd4 353 (24%) vl 29993
jan 08: cd4 332 (26%) vl 33308
mar 08: cd4 392 (23%) vl 75548
jun 08: cd4 325 (27%) vl 45880
oct 08: cd4 197 (20%) vl 154000 <== aids diagnosis
nov 2 08 start Atripla
nov 30 08: cd4 478 (23%) vl 1880 !!!!!!!!!!!!!!!!!!!!!!!!!!
feb 19 09: cd4 398 (24%) vl 430 getting there!
apr 23 09: cd4 604 (29%) vl 50 woohoo :D :D
jul 30 09: cd4 512 (29%) vl undetectable :D :D
may 27 10: cd4 655 (32%) vl undetectable :D :D

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Offline FiercenBed

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  • Posts: 183
Re: Conflicting Results Resistance Testing
« Reply #3 on: May 19, 2007, 11:17:51 AM »
hiding mutations.....great. learn something new every day. well @ least im not crazy. thanx for the info milker!

Offline budndallastx

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  • Posts: 463
Re: Conflicting Results Resistance Testing
« Reply #4 on: May 20, 2007, 05:47:38 PM »
As explained to me,  there isn't one particular strain inside a person.  The virus will mutate (with or without meds) and some mutations will not be viable so they will die off.  THe genotype tests will identify the most predominant viruses in the body but there could be other types too small in number to be picked up in the test.  If the virus mutates into a drug resistant strain, this strain of virus will become the predominant one in the body and appear on future tests.  The idea behind HAART is there would have to be a particular cascade of mutuations to get through all three types of drugs.  This may happen considering the rate at which the virus reproduces but the current conventional wisdom is this will be years into the future.    Keeping the VL undetectable slows the rate of mutations allowing the body to recover somewhat. 
Meds since: 11/20/2006
Sustiva / Truvada
12/08/2008 VL:<48 CD4 622 (38%)   
9/8/2008 VL:<48 CD4 573 (30%)
5/2008 VL:<48 CD4 464 (30%)
1/2008  VL: <50  CD4 425(28%)
9/2007   VL: <50  CD4 465 (27%)
6/2007   VL: <50   CD4 443 (26%)
3/2007  VL: <50   CD4 385 (25%)
12/2006 - VL: <50   CD4: 384 (25%)
11/2006 - VL:  22K  CD4: 208 (18%)


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