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Author Topic: Dr. Kang's therapeutic vaccine nearing FDA approval  (Read 6069 times)

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Offline J220

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Dr. Kang's therapeutic vaccine nearing FDA approval
« on: May 09, 2007, 09:57:16 PM »
Nothing too substatially new on this, but it's an update from the University of Western Ontario's page on Dr. Yong Kang ( http://communications.uwo.ca/com/alumni_gazette/research_notes/aids_vaccine_could_be_available_within_three_years_2007041912906/ )

In short, the development of the therapeutic vaccine is proceeding as planned, and is actually being manufactured as we speak (or rather, read/ write), in anticipation of phase I and II trials.

According to Doctor Kang, the estimated time for this to be ready is three years. In my view, this is one of the most promising vaccines under development out there!

________________________________


AIDS vaccine could be available within three years

"This vaccine has the potential of saving millions of lives,” says Yong Kang, a professor in the Schulich School of Medicine & Dentistry at The University of Western Ontario. It’s always wise to have realistic expectations, but Kang hopes he is closer to finding a cure for HIV/AIDS – and he’s already much nearer to succeeding than most have ever been.

Kang’s tireless quest to develop a vaccine against HIV/AIDS has spanned nearly two decades and has just entered a new phase. “The results look encouraging, and we are now moving onto pre-clinical animal toxicology trials,” he says.

Kang’s work has produced one of the few technologies to make it so far in a process where dozens of other potential vaccines have failed. His technology could not only produce antibodies against HIV, but also prime T-cells to destroy cells harboring the virus, essentially curing a patient with HIV infection.

“We created a genetically modified HIV and recombinant human adenoviruses to develop a vaccine which can prevent HIV infection and clear HIV-infected cells. It can produce antibodies against HIV and educate one type of white blood cells to find infected cells and kill them,” explains Kang.

With the help of Western’s Industry Liaison office, Kang licensed his inventions to Curocom, a publicly traded holding company in Korea. Curocom is sponsoring research in Kang’s lab and recently opened a subsidiary office at Western’s Research Park to accelerate aspects of the commercialization process of the HIV vaccine program.

Kang’s vaccine is currently being manufactured in a Maryland laboratory in anticipation of FDA approval to continue with Phase 1 and 2 human clinical trials. His vaccine could be available for therapeutic use within three years and for use as a preventive vaccine within the next six years.
« Last Edit: May 09, 2007, 10:01:03 PM by J220 »
"Hope is my philosophy
Just needs days in which to be
Love of Life means hope for me
Born on a New Day" - John David

Offline Jake72

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Re: Dr. Kang's therapeutic vaccine nearing FDA approval
« Reply #1 on: May 09, 2007, 10:57:41 PM »
That would be extremely cool, of course, but how are they thinking of going through phases i, II, and III...plus getting regulatory approval...in three years??  Would that even be possible under the best of conditions?

Offline milker

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Re: Dr. Kang's therapeutic vaccine nearing FDA approval
« Reply #2 on: May 09, 2007, 10:59:57 PM »
Available within 3 years and he hasn't started phase 1 yet?

Next!

Milker.
mid-dec: stupid ass
mid-jan: seroconversion
mid-feb: poz
mar 07: cd4 432 (35%) vl 54000
may 07: cd4 399 (28%) vl 27760
jul 07: cd4 403 (26%) vl 99241
oct 07: cd4 353 (24%) vl 29993
jan 08: cd4 332 (26%) vl 33308
mar 08: cd4 392 (23%) vl 75548
jun 08: cd4 325 (27%) vl 45880
oct 08: cd4 197 (20%) vl 154000 <== aids diagnosis
nov 2 08 start Atripla
nov 30 08: cd4 478 (23%) vl 1880 !!!!!!!!!!!!!!!!!!!!!!!!!!
feb 19 09: cd4 398 (24%) vl 430 getting there!
apr 23 09: cd4 604 (29%) vl 50 woohoo :D :D
jul 30 09: cd4 512 (29%) vl undetectable :D :D
may 27 10: cd4 655 (32%) vl undetectable :D :D

Now accepting applications from blowjob ninjas™

Offline J220

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Re: Dr. Kang's therapeutic vaccine nearing FDA approval
« Reply #3 on: May 09, 2007, 11:34:45 PM »
One year per phase doesn't seem unresonable, assuming it works well.
« Last Edit: May 09, 2007, 11:48:35 PM by J220 »
"Hope is my philosophy
Just needs days in which to be
Love of Life means hope for me
Born on a New Day" - John David

Offline milker

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Re: Dr. Kang's therapeutic vaccine nearing FDA approval
« Reply #4 on: May 10, 2007, 12:03:43 AM »
That would be a first, and HIV is not FDA's priority.

I wouldn't get excited before phase II results. I cannot get excited if the guy hasn't even tried his medicine on anyone yet. We've seen too many of those. However, if it reaches phase II, then fuck yeah.

3 years fda approval for something that has not even started phase I has never been seen before. And the FDA has other things to be excited about: diabetes, cancer, etc. I seriously doubt about this being FDA approved in 3 years.

Milker.
mid-dec: stupid ass
mid-jan: seroconversion
mid-feb: poz
mar 07: cd4 432 (35%) vl 54000
may 07: cd4 399 (28%) vl 27760
jul 07: cd4 403 (26%) vl 99241
oct 07: cd4 353 (24%) vl 29993
jan 08: cd4 332 (26%) vl 33308
mar 08: cd4 392 (23%) vl 75548
jun 08: cd4 325 (27%) vl 45880
oct 08: cd4 197 (20%) vl 154000 <== aids diagnosis
nov 2 08 start Atripla
nov 30 08: cd4 478 (23%) vl 1880 !!!!!!!!!!!!!!!!!!!!!!!!!!
feb 19 09: cd4 398 (24%) vl 430 getting there!
apr 23 09: cd4 604 (29%) vl 50 woohoo :D :D
jul 30 09: cd4 512 (29%) vl undetectable :D :D
may 27 10: cd4 655 (32%) vl undetectable :D :D

Now accepting applications from blowjob ninjas™

Offline J220

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Re: Dr. Kang's therapeutic vaccine nearing FDA approval
« Reply #5 on: May 10, 2007, 12:07:41 AM »
Yes, it would be a first, but then again, all we need is one vaccine to work! This one could be it.
"Hope is my philosophy
Just needs days in which to be
Love of Life means hope for me
Born on a New Day" - John David

Offline hahaha

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Re: Dr. Kang's therapeutic vaccine nearing FDA approval
« Reply #6 on: May 10, 2007, 04:12:31 AM »
Hey, USA is NOT the only place that have FDA, OK?
Probably the vaccine already passed phase I or II in, let's say, Japan or France.  and may be passed phase III in those place in 2010.  THEN, the vaccine will come back to US for USA government approval.  In that case, we migth have to fly to Japan or France to get the shot.

YAHHOOOOO!!!
Aug 9, 2006 Get infected in Japan #$%^*
Oct 2006 CD4 239
Nov 2006 CD4 299 VL 60,000
Dec 1, Sustiva, Ziagan and 3TC
Jan 07, CD4 400

Offline Jake72

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Re: Dr. Kang's therapeutic vaccine nearing FDA approval
« Reply #7 on: May 10, 2007, 08:01:14 AM »
Maybe, but the article states that the vaccine is about to enter phase I and doesn't refer to phases in any other country.  Just some research in Korea.

I guess we'll find out in 2010, huh?  I agree with Milker that we should probably wait until after phase II to get more enthusiastic, but it is an interesting idea. 

Just out of curiosity, didn't the first protease inhibitors zip through trials and FDA approval REALLY fast?  I seem to remember reading it was a few months for phase II and maybe a year for phase III, though maybe I'm wrong.  At the time it seemed like the meds came out of nowhere.   

Offline appleboy

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Re: Dr. Kang's therapeutic vaccine nearing FDA approval
« Reply #8 on: May 10, 2007, 08:27:01 AM »
It seems if the FDA wants something approved it will get approved.  I hope the research this guy has done is leading to a cure and vaccine.  I would love to see HIV/AIDS disappear.  I know I don't want this stuff so bring it on!
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Offline ARMANDO

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Re: Dr. Kang's therapeutic vaccine nearing FDA approval
« Reply #9 on: May 10, 2007, 08:30:49 AM »
THERE IS NO MONEY IN A CURE!!!

Offline milker

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Re: Dr. Kang's therapeutic vaccine nearing FDA approval
« Reply #10 on: May 10, 2007, 10:23:10 AM »
So a little bit of research shows that Dr Kang already claimed a vaccine 19 years ago, but failed. All communication about this comes from Western, a university in Ontario where he works as a teacher in virology. The first communication about this was when he patented his new vaccine on october 17, 2006. The communication posted by J220 is from the Western Alumni Gazette.

I haven't seen anything tangible about this beyond the doors of Western university, so I will not hold my breath. However, if he's been working on a vaccine for 20 years, it could well be that he finally found something that works, so let's wait and see :)

Milker (who wants the magic shot)
mid-dec: stupid ass
mid-jan: seroconversion
mid-feb: poz
mar 07: cd4 432 (35%) vl 54000
may 07: cd4 399 (28%) vl 27760
jul 07: cd4 403 (26%) vl 99241
oct 07: cd4 353 (24%) vl 29993
jan 08: cd4 332 (26%) vl 33308
mar 08: cd4 392 (23%) vl 75548
jun 08: cd4 325 (27%) vl 45880
oct 08: cd4 197 (20%) vl 154000 <== aids diagnosis
nov 2 08 start Atripla
nov 30 08: cd4 478 (23%) vl 1880 !!!!!!!!!!!!!!!!!!!!!!!!!!
feb 19 09: cd4 398 (24%) vl 430 getting there!
apr 23 09: cd4 604 (29%) vl 50 woohoo :D :D
jul 30 09: cd4 512 (29%) vl undetectable :D :D
may 27 10: cd4 655 (32%) vl undetectable :D :D

Now accepting applications from blowjob ninjas™

Offline J220

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  • Posts: 587
Re: Dr. Kang's therapeutic vaccine nearing FDA approval
« Reply #11 on: May 10, 2007, 10:32:20 AM »
Maybe, but the article states that the vaccine is about to enter phase I and doesn't refer to phases in any other country.  Just some research in Korea. Just out of curiosity, didn't the first protease inhibitors zip through trials and FDA approval REALLY fast?  I seem to remember reading it was a few months for phase II and maybe a year for phase III, though maybe I'm wrong.  At the time it seemed like the meds came out of nowhere.   

This appears to be true, I don't think this has been tested in humans, and of course that remains the main- and the only one the matters- caveat. As Dr. Kang himself states, just because the vaccine worked properly in animals, it doesn't necessarily mean it will work with humans. This is refreshing caution, coming from the researcher and designer of the vaccine himself. On the other hand, he, and Curocom, seem mighty confident that things will work out, confident enough that they are putting up $15 million dollars, with a commitment of $50 million total, for taking this all the way to production So, only thing to do now is watch, and hope...J.
"Hope is my philosophy
Just needs days in which to be
Love of Life means hope for me
Born on a New Day" - John David

Offline Jake72

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  • Posts: 145
Re: Dr. Kang's therapeutic vaccine nearing FDA approval
« Reply #12 on: May 10, 2007, 12:59:27 PM »
So a little bit of research shows that Dr Kang already claimed a vaccine 19 years ago, but failed. All communication about this comes from Western, a university in Ontario where he works as a teacher in virology. The first communication about this was when he patented his new vaccine on october 17, 2006. The communication posted by J220 is from the Western Alumni Gazette.

I haven't seen anything tangible about this beyond the doors of Western university, so I will not hold my breath. However, if he's been working on a vaccine for 20 years, it could well be that he finally found something that works, so let's wait and see :)

Milker (who wants the magic shot)

True, but that being said, I'd be more willing to take seriously posts about research coming from Canada and Korea than those weird posts about an Iranian cure that were popping up in here a few months ago  ;D  ;D 

Offline SASA39

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Oct.     `06.  CD4=58  ?    %       VL not perform. ?!?
25.Dec.`06.         203       14        VL= 0
29.May.`07.    broken device        VL=1363
20.June`07     broken device        VL=0
25.Dec `07  CD4=582                  VL=70
14.May `08  CD4=448
29.July `08                                  VL=0
26.Nov `08  CD4=674                    VL=179
16.Mar `09  CD4=554                    VL=0
19.Jan`10 CD4=715               
03.Mar`10                                    VL=0
24.Aug`10 CD4=524                     VL=0
04.Dec`10 CD4=626                     VL=0
15.Sep`11                                   VL=93
17.Nov`11                                   VL=0
05/26 .Jul`12 CD4=713                 VL=0
28.Nov`12 CD4=916                     VL=0
09.May`13                                 VL=0

Offline hahaha

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  • Posts: 123
Re: Dr. Kang's therapeutic vaccine nearing FDA approval
« Reply #14 on: May 11, 2007, 12:17:42 AM »
Following is the recent publication by Dr. Kang.
Chung Y, Chang JH, Kim BS, Lee JM, Kim HY, Kang CY.
Laboratory of Immunology, Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea.

In the spleen, exogenous antigen is preferentially presented by CD8alpha(+)CD11b(-) DC to CD8 T cells and by CD8alpha(-)CD11b(+) DC to CD4 T cells. However, it is not yet clear whether the same rule applies to other secondary lymphoid organs. To address this issue, we first classified secondary lymphoid tissues into three categories based on the expression pattern of CD8alpha and CD11b in C57BL/6 and BALB/c mice: (a) spleen, (b) mesenteric lymph node (MLN) and (c) other peripheral lymph nodes (PLN). We then analyzed the OVA-specific T cell-stimulating capacity of each DC subset after intravenous injection with soluble OVA. Our results show that, regardless of tissue origin, CD8alpha(-)CD11b(+) DC generally present OVA to CD4 T cells, a finding that held true as well for CD8alpha(+)CD11b(+) DC in PLN. In striking contrast, CD8alpha(+)CD11b(-) DC in spleen, CD8alpha(-)CD11b(+) DC in MLN and CD8alpha(+)CD11b(+) DC in PLN mainly cross-present OVA to CD8 T cells in their respective tissues. Of note, CD8alpha(-)CD11b(+) DC in MLN and CD8alpha(+)CD11b(+) DC in PLN present OVA to both CD4 T and CD8 T cells. Therefore, the antigen-presenting capacity of each distinct DC subset is determined by its anatomic environment in combination with its surface phenotype.
Aug 9, 2006 Get infected in Japan #$%^*
Oct 2006 CD4 239
Nov 2006 CD4 299 VL 60,000
Dec 1, Sustiva, Ziagan and 3TC
Jan 07, CD4 400

Offline northernguy

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Re: Dr. Kang's therapeutic vaccine nearing FDA approval
« Reply #15 on: May 11, 2007, 01:13:10 AM »
...
I haven't seen anything tangible about this beyond the doors of Western university, so I will not hold my breath. However, if he's been working on a vaccine for 20 years, it could well be that he finally found something that works, so let's wait and see :)

Milker (who wants the magic shot)

Western is a very reputable university, the Canadian equivalent of an Ivy League school.
Apr 28/06 cd4 600 vl 10,600 cd% 25
Nov 8/09 cd4 510 vl 49,5000 cd% 16
Jan 16/10 cd4 660 vl 54,309 cd% 16
Feb 17/10 Started Atripla
Mar 7/10 cd4 710 vl 1,076 cd% 21
Apr 18/10 cd4 920 vl 268 cd% 28
Jun 19/10 cd4 450 vl 60 cd% 25
Aug 15/10 cd4 680 vl 205 cd% 27
Apr 3/11 cd4 780 vl <40 cd% 30
Jul 17/11 cd4 960 vl <40 cd%33
April 15/12 cd4 1,010 vl <40 cd% 39
April 20/12 Switched to Viramune + Truvada
Aug 2/12 cd4 1040, vl <40, cd% 38
Oct 19 cd4 1,110 vl <40 cd% 41

Offline blondbeauty

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Re: Dr. Kang's therapeutic vaccine nearing FDA approval
« Reply #16 on: May 12, 2007, 11:20:34 AM »
Then what will happen with forums, with the POZ magazine and many big pharma projects in development?  :-\
The only member in these forums approved by WINBA: World International Nail and Beauty Association.
Epstein Barr +; CMV +; Toxoplasmosis +; HIV-1 +.
Counts when starting treatment:
V.L.:80.200 copies. CD4: 25%=503
Started Sustiva-Truvada 14/August/2006
Last V.L.count (Oct 2013): Undetectable
Last CD4 count (OCT 2013): 52%= 933

Offline dingowarrior

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Re: Dr. Kang's therapeutic vaccine nearing FDA approval
« Reply #17 on: May 12, 2007, 01:02:05 PM »
No offense to fellow members,but i'd take a vaccine/cure over a forum any day.
Then what will happen with forums, with the POZ magazine and many big pharma projects in development?  :-\

no offense,but i'd take a vaccine/cure over a forum any day.

Offline northernguy

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Re: Dr. Kang's therapeutic vaccine nearing FDA approval
« Reply #18 on: May 12, 2007, 09:16:52 PM »
THERE IS NO MONEY IN A CURE!!!

Well, yes there is.  First for the patentholder and manufacturer.  Then in those advanced countries where gov't pay for HIV meds there are huge cost savings to be realized.  And for the private insurers, likewise huge savings.  For employers who will see a reduction in benefit costs, huge savings.  So maybe big pharma loses,though I suspect a lot would like the "halo' that goes with discovering an HIV "cure".
Apr 28/06 cd4 600 vl 10,600 cd% 25
Nov 8/09 cd4 510 vl 49,5000 cd% 16
Jan 16/10 cd4 660 vl 54,309 cd% 16
Feb 17/10 Started Atripla
Mar 7/10 cd4 710 vl 1,076 cd% 21
Apr 18/10 cd4 920 vl 268 cd% 28
Jun 19/10 cd4 450 vl 60 cd% 25
Aug 15/10 cd4 680 vl 205 cd% 27
Apr 3/11 cd4 780 vl <40 cd% 30
Jul 17/11 cd4 960 vl <40 cd%33
April 15/12 cd4 1,010 vl <40 cd% 39
April 20/12 Switched to Viramune + Truvada
Aug 2/12 cd4 1040, vl <40, cd% 38
Oct 19 cd4 1,110 vl <40 cd% 41

Offline NYCguy

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Re: Dr. Kang's therapeutic vaccine nearing FDA approval
« Reply #19 on: May 16, 2007, 02:12:53 PM »
I was excited about this one when I read the first press releases in the fall during my 'obsessive period' when I still didn't know if I was poz or not and thought I could find a cure online - boyfriend was poz but tests were still coming back neg for me.  Boy am I glad that time is over...although not so glad how it came out

ANYWAY - it sounded good at the time.  As far as I can tell Dr. Kang and Western are the only ones working on this and it isn't already being tested anywhere else, as was suggested above.  The curocom investment does imply that someone with resources believes in this.  Does seem strange that there is so much hype considering it hasn't been tried in humans yet...but Kang has a long and good rep, so lets keep our fingers and toes and everything else crossed.

Of course my big question for this and any other time the word 'cure' gets thrown around...what about the brain and other places where this damn virus hides besides the blood?
11/9/06 = #$%^&!
sometime early Dec 2006:
CD4 530 20%/VL >250,000 (&*$$%!!)
started Reyataz300mg/Norvir/Truvada 12-27-06.
1/30/07 CD4 540 30%/VL <400
4/07 CD4 600+ 33%/VL <50
6/9/07 CD4 720 37%/VL <50
10/15/07 CD4 891 (!) %? VL <50
1/2010 CD4 599 (37%) VL<50 (drop due to acute HCV)
9/2010 - looks like HCV is gone for good! And I'm finally drinking again, thank GOD
2013 - considering a switch to Stribild. but I love my Kidneys (but I hate farting all the time!)...
June 2013 - switched to Stribild.  so far so good...

Offline J220

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Re: Dr. Kang's therapeutic vaccine nearing FDA approval
« Reply #20 on: May 17, 2007, 12:11:05 PM »
I think if the vaccine turns out to be capable of eliciting an effective antidbody response in humas as it did in animals, it will be systemic, meaning the modified immune cells will seek out and kill infected cells wherever they may be.

As opposed to drugs and medications, which do have limitations in terms of reaching all areas in the body- i.e. brain- once the body is 'trained' with a vaccine to fight off a particular pathogen, it will do so with its immune system in all areas of the body.

Mind you, this is my understanding, nothing more.

And yes, this seems promising. No question that Dr. Kang himself stands on solid reputation. This doesn't translate into immediate success for his vaccine, but at least we can rule out quackery on this one. The man knows his business. May he be the one to have found the cure!!! Regards, J.
« Last Edit: May 17, 2007, 12:13:45 PM by J220 »
"Hope is my philosophy
Just needs days in which to be
Love of Life means hope for me
Born on a New Day" - John David

Offline NYCguy

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Re: Dr. Kang's therapeutic vaccine nearing FDA approval
« Reply #21 on: May 17, 2007, 07:04:09 PM »
Amen to that!
11/9/06 = #$%^&!
sometime early Dec 2006:
CD4 530 20%/VL >250,000 (&*$$%!!)
started Reyataz300mg/Norvir/Truvada 12-27-06.
1/30/07 CD4 540 30%/VL <400
4/07 CD4 600+ 33%/VL <50
6/9/07 CD4 720 37%/VL <50
10/15/07 CD4 891 (!) %? VL <50
1/2010 CD4 599 (37%) VL<50 (drop due to acute HCV)
9/2010 - looks like HCV is gone for good! And I'm finally drinking again, thank GOD
2013 - considering a switch to Stribild. but I love my Kidneys (but I hate farting all the time!)...
June 2013 - switched to Stribild.  so far so good...

Offline Jake72

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Re: Dr. Kang's therapeutic vaccine nearing FDA approval
« Reply #22 on: May 18, 2007, 10:41:02 AM »
With regard to the brain, etc., how is it that syphilis (and yes, I KNOW it's a bacteria, but the point is that it, like HIV, is a contagion) can infect the brain, sexual fluids, etc., and yet antibiotics can somehow penetrate everywhere to kill it off completely, thus curing it.  Moreover, this was all discovered/approved in the 1940s, when technology was a joke compared to what it is today.  Wouldn't this prove that a medicine can in fact penetrate all (or nearly all) regions of the body to kill off an invader?  If antibiotics can do this to syphilis, why can't a potent set of antiretrovirals or a therapeutic vaccine do this to HIV?

 


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