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Author Topic: Just call me "Sweet Pee"  (Read 1366 times)

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Offline whizzer

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  • Posts: 364
Just call me "Sweet Pee"
« on: July 05, 2007, 09:19:03 PM »
....cuz I have glucose in my urine.

Urinary glucose +2 last week, +1 today.  Blood glucose=94, Creatinine Clearance normal.

Current meds=Truvada, Invirase, Norvir, Fuzeon.

Doc thinks the tenofovir in the Truvada may be the source of the problem and is suggesting we switch to abacavir.

Try as I might, I can't find a whole lot of info on the link between tenofovir and urinary glucose.  Anybody have any info on this?

I'd appreciate any info you might have.

THANKS,
Whizzer

Offline milker

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  • Posts: 4,034
  • Protected phone sex
Re: Just call me "Sweet Pee"
« Reply #1 on: July 05, 2007, 10:12:41 PM »
With a name like Whizzer, no wonder you pay attention to your pee :D

Ok I have nothing else to say, I just had to post this stupid comment :)

Milker.
mid-dec: stupid ass
mid-jan: seroconversion
mid-feb: poz
mar 07: cd4 432 (35%) vl 54000
may 07: cd4 399 (28%) vl 27760
jul 07: cd4 403 (26%) vl 99241
oct 07: cd4 353 (24%) vl 29993
jan 08: cd4 332 (26%) vl 33308
mar 08: cd4 392 (23%) vl 75548
jun 08: cd4 325 (27%) vl 45880
oct 08: cd4 197 (20%) vl 154000 <== aids diagnosis
nov 2 08 start Atripla
nov 30 08: cd4 478 (23%) vl 1880 !!!!!!!!!!!!!!!!!!!!!!!!!!
feb 19 09: cd4 398 (24%) vl 430 getting there!
apr 23 09: cd4 604 (29%) vl 50 woohoo :D :D
jul 30 09: cd4 512 (29%) vl undetectable :D :D
may 27 10: cd4 655 (32%) vl undetectable :D :D

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Offline aztecan

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  • Posts: 5,399
  • 29 years positive, 57 years a pain in the butt
Re: Just call me "Sweet Pee"
« Reply #2 on: July 06, 2007, 01:43:10 PM »
You know Whiz, with a name like that and a subject like this, I could make a really kinky comment.  ;)

That said, I've never heard of a correlation between Tenofovir and urinary glucose and haven't had much luck finding info on it.

Keep us posted on this, please.

HUGS,

Mark
"May your life preach more loudly than your lips."
~ William Ellery Channing (Unitarian Minister)

Offline newt

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  • the one and original newt
Re: Just call me "Sweet Pee"
« Reply #3 on: July 07, 2007, 05:37:28 AM »
Mr Whizz

You and my friends above are correct, there is no documented relationship between urinary glucose, tenofovir and kidney function. But this is because the drug's adverse effect on the kidneys has been judged using other tests (creatine clearance, glomular filtration) as these are more specific (eg avoid the is it/isn't it insulin resistance question).

At my clinic sugar in your pee would trigger (1) full kidney function testing (2) insulin resistance testing.

Urine in glucose suggests kidney dysfunction, but not a cause. Therefore, before jumping to conclusions I personally would want to look at:

- cause ie could it be something other than the drugs?
- an insulin resistance screen, as PI use can lead to insulin resistance and sugar in your pee should create a high index of suspicion for this
- a fuller kidney function test, eg glomular filtration rate
- full liver panel, as sugar in your pee can indicate liver damage
- adrenal gland function + blood pressure
- resistance ie is abacavir viable/effective?

Your blood sugar is within normal range, so your doc's judgement on this being indicative of reduced kidney function may be correct (and maybe s/he's done all/most of the above already). But that your creatine clearance is normal suggests not... hmmm

Given you are on what might be considered an advanced combo, the picture on nuke resistance needs to be part of the decision-making.

Hope this helps

- matt
« Last Edit: July 08, 2007, 07:26:17 AM by newt »
"The object is to be a well patient, not a good patient"

 


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