Quantcast

Subscribe to:
POZ magazine
E-newsletters
Join POZ: Facebook MySpace Twitter Pinterest
Tumblr Google+ Flickr MySpace
POZ Personals
Sign In / Join
Username:
Password:
Welcome, Guest. Please login or register.
July 28, 2014, 07:02:42 AM

Login with username, password and session length


Members
Stats
  • Total Posts: 632070
  • Total Topics: 47855
  • Online Today: 205
  • Online Ever: 585
  • (January 07, 2014, 02:31:47 PM)
Users Online
Users: 4
Guests: 141
Total: 145

Welcome


Welcome to the POZ/AIDSmeds Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ/AIDSmeds community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Forbes: HIV Drugs may raise heart attack risk!  (Read 2690 times)

0 Members and 1 Guest are viewing this topic.

Offline thirtysomething

  • Member
  • Posts: 124
Forbes: HIV Drugs may raise heart attack risk!
« on: April 28, 2007, 12:25:20 AM »
Check this out.. Now one more thing to worry about!   >:( And worse, almost everybody who is dead in my family and near relatives have died of Heart Attack!

http://www.forbes.com/forbeslife/health/feeds/hscout/2007/04/25/hscout603990.html

Offline xyahka

  • Member
  • Posts: 778
  • Dance together!! aha!! aha!! I like it!!
Re: Forbes: HIV Drugs may raise heart attack risk!
« Reply #1 on: April 28, 2007, 02:32:58 AM »
The only thing that will cause me a heart attack regarding hiv drugs... will be their price!!!  ::)
13/03/07 1er diagnóstico /Peso: 79kg
19/04/07 CD4: 494 /CViral: ?? /Peso: 80kg
19/07/07 CD4: 659 /CViral: ?? /Peso: 79.5kg
06/03/08 CD4: 573 (después de meses muy deprimido) /CViral: ?? /Peso: 79kg
17/09/08 CD4: ?? /CViral: ?? /Peso: 84Kg
06/02/09 CD4: ?? /CViral: ?? /Peso: 85Kg /HCV: Neg /HBV: Neg.
07/03/09 CD4: ?? /CViral: ?? /Peso: 87Kg / Gym 3días/semana y Natación 2días/semana.
12/05/09 CD4: 470 /Cviral: ?? /Peso: 87Kg.
08/07/09 CD4: ? /CViral: ? /Peso: 77Kg.
09/12/09 CD4: 510 /CViral: ? /Peso: 78kg. No medicinas aún
10/01/10 CD4: ? /CViral: ? /Peso: 76Kg.
15/05/10 CD4: 320 /CViral: ? /Peso: 76Kg.
01/02/11 CD4: 291 /CViral: ? /Peso: 78kg.
05/05/11 CD4: 366 /CViral: ? /Peso: 78kg.
27/07/11 CD4: 255 /CViral: 138000 /Peso: 78kg.

Disfrutando y aceptando una nueva vida...

Offline J.R.E.

  • Member
  • Posts: 7,099
  • Joined Dec-2003 Living positive, since 1985.
Re: Forbes: HIV Drugs may raise heart attack risk!
« Reply #2 on: April 28, 2007, 08:28:20 AM »
Just got this in my email box this morning, from aidsmap : Similar article

"Are people with HIV at higher risk of heart disease? Further research suggesting an elevated risk was published this week, and its conclusions are sobering.

HIV-positive people receiving treatment at two major US hospitals were 75% more likely to experience a heart attack, and women were almost three times as likely to experience a heart attack as their HIV-negative counterparts.

The findings could not be entirely explained by the presence of elevated cholesterol levels, high blood pressure or diabetes.

There are several reasons to think that the findings of the study, carried out by Steven Grinspoon and colleagues at Massachusetts General Hospital, are robust.

Firstly, the study had a very large control group of HIV-negative patients, and a substantial number of patient-years of HIV-positive follow-up.

Secondly, the researchers chose one hard endpoint – myocardial infarction – rather than the spectrum of cardiovascular disease investigated in some other studies.

Thirdly, the study had a higher proportion of African-Americans than other studies, and one-third of the HIV-positive patients were women, making its findings more representative of the HIV-positive in the United States than other studies, such as review of the Kaiser Permanente database in California.

Analysis of the DAD cohort, which looked at HIV-positive patients in Europe and Australia also found that the elevation in risk might be as much as threefold, but they also found that the year-on-year risk of heart attack was probably around 1% based on their data.

In other words, although these findings are sobering, they shouldn’t discourage anyone from taking antiretroviral therapy.

What they should do is encourage far greater discussion of risks for heart disease between doctors and patients. The Boston researchers found that they had data on the smoking habits of only 22% of their HIV-positive patients, despite the fact that patients were followed until 2004, when the risk of cardiovascular disease was already being widely discussed by HIV doctors.

More research is clearly needed in this area, but the findings add further weight to the case for choosing antiretroviral regimens that don’t add to the risk of heart disease, and for smoking cessation advice to be given high priority in the work of any HIV clinic."



Ray




Current Meds ; Viramune, Epzicom, 40mg of simvastatin, 12.5mg of Hydrochlorothiazide.
Metoprolol tartrate 25mg



http://forums.poz.com/index.php?topic=40802.0

http://forums.poz.com/index.php?topic=45159.0

http://forums.poz.com/index.php?topic=39722.msg495621;topicseen#msg495621

http://forums.poz.com/index.php?topic=46806.0

http://forums.poz.com/index.php?topic=39414.msg491701#msg491701


 In October of 2003, My t-cell count was 16, Viral load was over 500,000, Percentage at that time was 5%. I started my first  HAART regimen  on October 24th,03.

 As of 6/4/14,  t-cells are at 423, Viral load <40

 Current % is at 13% 

  
 62 years young.

Offline ndrew

  • Member
  • Posts: 695
  • ....-.-.-.-.-.....
Re: Forbes: HIV Drugs may raise heart attack risk!
« Reply #3 on: April 28, 2007, 08:46:57 AM »
I suppose there are worse ways to go... like drowning or dying in a fire...

Offline allopathicholistic

  • Member
  • Posts: 3,258
Re: Forbes: HIV Drugs may raise heart attack risk!
« Reply #4 on: April 28, 2007, 09:33:02 AM »
Thanks for sharing that link. It says The findings, published in the April 26 issue of the New England Journal of Medicine, come on the heels of a related study published Tuesday in the Journal of Clinical Endocrinology and Metabolism. That research, by a team at Harvard Medical School, found that HIV infection -- and possibly, treatment -- boosted rates for heart attack nearly twofold. I say toss in a few dozen bottles of red wine and start the study over.  :P Ugh, what can we do?

Offline MariaDee

  • Member
  • Posts: 6
Re: Forbes: HIV Drugs may raise heart attack risk!
« Reply #5 on: April 28, 2007, 04:01:32 PM »
Great....
I was looking for more good news....
I've been poz for a little over a year and already, my blood pressure is through the roof, just found out Friday that my cholesterol is way off the charts, I'm extremely depressed, and now I can look forward to maybe having a heart attack among other things of course that I have yet to experience.

Go ahead give it to me..... 'welcome to being poz'


Offline BT65

  • Global Moderator
  • Member
  • Posts: 9,847
  • Vegas baby!
Re: Forbes: HIV Drugs may raise heart attack risk!
« Reply #6 on: April 28, 2007, 04:27:22 PM »
Hey Maria:
  All I can say is "welcome!"  My cholesterol was always normal, UNTIL I started the antiretrovirals.  Then it doubled!  Good luck!
I've never killed anyone, but I frequently get satisfaction reading the obituary notices.-Clarence Darrow

Offline MariaDee

  • Member
  • Posts: 6
Re: Forbes: HIV Drugs may raise heart attack risk!
« Reply #7 on: April 28, 2007, 04:48:11 PM »
Thanks Betty.....
So it is the meds?  My doc said I needed to watch what I eat.  I didn't think it was my diet 'cause nothing has changed. 

Offline RapidRod

  • Member
  • Posts: 15,277
Re: Forbes: HIV Drugs may raise heart attack risk!
« Reply #8 on: April 28, 2007, 06:08:45 PM »
I have to see the cardiologist twice a year anyway, so this isn't going to add any more worry on me.

Offline Matty the Damned

  • Member
  • Posts: 12,198
  • Ninja Please
Re: Forbes: HIV Drugs may raise heart attack risk!
« Reply #9 on: April 28, 2007, 06:14:06 PM »
It's things like this which make Matty the Damned grateful he doesn't have a heart.

MtD

Offline Iggy

  • Member
  • Posts: 2,435
Re: Forbes: HIV Drugs may raise heart attack risk!
« Reply #10 on: April 29, 2007, 10:00:30 AM »
This is what many of the LTS have been telling this board for a long time now.  When I say "this" I don't necessarily mean this specific study, but the point that many have been trying to let us know (often to deaf and defiant ears) that the very treatments that we are taking to fight HIV are having, or have the potential to have, profound negative effects on the rest of our body.

There are many here who have talked openly about their heart issues as well as liver, kidney, eyes, joints and just about ever part of the body that they feel is starting to weaken if not outright fail because of the treatments - not HIV.

This is why so many of them have gotten frustrated at others talking about this being a manageable disease- because it is a false argument as it is not the disease that we have to manage anymore but the very treatments and side effect (both short and long term).  On a related side note - it has always angered me when others who are not experiencing such effects  are are new on treatments are the ones to state to them that maybe it's just old age or that they are being overly negative.

I hope you don't see my response as unsympathetic - it's not - I very much fear as you do my heart developing problems someday.  I also hope you don't see this as some rally not to follow your regimen - It's not.

What this is however is a hope that more people will realize that though we've come a long way in treatments and the ability to extend our life spans as HIV poz people - we need to be aware that living with HIV has for most of us (whether we know it or not) moved from a direct fight against HIV to a fight against to collateral damage of the treatments  and we should not be lulled into complacency because the battle is not an obvious one.
« Last Edit: April 29, 2007, 10:02:54 AM by Iggy »

Offline J.R.E.

  • Member
  • Posts: 7,099
  • Joined Dec-2003 Living positive, since 1985.
Re: Forbes: HIV Drugs may raise heart attack risk!
« Reply #11 on: April 29, 2007, 10:25:51 AM »
This is what many of the LTS have been telling this board for a long time now.  When I say "this" I don't necessarily mean this specific study, but the point that many have been trying to let us know (often to deaf and defiant ears) that the very treatments that we are taking to fight HIV are having, or have the potential to have, profound negative effects on the rest of our body.



Absolutely !! I've known this for this for a quite a while. Having friends, that have had strokes in their 40's and open heart surgery-- well.....

I think a many of the newly infected may not like to hear or read this news, but the fact is, it's out there. Which is one more reason, why we have to take care of ourselves to the best of our abilities.

I have always thought , that it will be a stroke or heart attack, or some heart disease, that will do me in, I've seen it happen to others before.



Ray
« Last Edit: April 29, 2007, 05:59:01 PM by J.R.E. »
Current Meds ; Viramune, Epzicom, 40mg of simvastatin, 12.5mg of Hydrochlorothiazide.
Metoprolol tartrate 25mg



http://forums.poz.com/index.php?topic=40802.0

http://forums.poz.com/index.php?topic=45159.0

http://forums.poz.com/index.php?topic=39722.msg495621;topicseen#msg495621

http://forums.poz.com/index.php?topic=46806.0

http://forums.poz.com/index.php?topic=39414.msg491701#msg491701


 In October of 2003, My t-cell count was 16, Viral load was over 500,000, Percentage at that time was 5%. I started my first  HAART regimen  on October 24th,03.

 As of 6/4/14,  t-cells are at 423, Viral load <40

 Current % is at 13% 

  
 62 years young.

Offline bocker3

  • Member
  • Posts: 3,358
  • You gotta enjoy life......
Re: Forbes: HIV Drugs may raise heart attack risk!
« Reply #12 on: April 29, 2007, 02:25:43 PM »
I think a many of the newly infected may not like to hear or read this news, but the fact is it's out there. Which is one more reason, why we have to take care of ourselves to the best of our abilities.

Ray,
I think that you have hit the nail on the head.  Being only 2 years into this, I try very hard (with up and down success) to focus on the positive, but NOT ignore the rest.  I may be having a pretty easy time of it right now, but I've read enough here and elsewhere, to know that this can change.  Of course, I also need to remember that I didn't know what was going to kill me before HIV and I still don't know what (or when) will now.  Therefore, I try to take care of myself -- I eat better than I used to, but still have room for improvement and I exercise much more regularly now.  Heart diseases has killed the majority of men in my family for generations, I started on statins 11 yrs ago because of my cholesterol.  It is currently well managed, even with my hiv meds, but heart disease has always been my most likely grim reaper.  If my meds end up causing my heart to kill me in 20, 30, 40 yrs -- so be it -- I know that without them I wasn't likely to make it 10 more.

In the article from the original link in this post, there was a very interesting paragraph:
Writing in an accompanying editorial in the journal, Dr. James Stein, of the University of Wisconsin School of Medicine and Public Health, said the actual increase of risk for heart attack from protease inhibitors "is not high." In fact, it remains much smaller than the danger posed by more typical risk factors such as aging, smoking and diabetes.

I think this speaks to one of your points -- take care of yourself.  It almost seems silly to worry about the increased risk in heart disease from life saving medicines when one continues to smoke or continues other behaviors that put your heart at risk.  So, taking care of ourselves is key.  Of course, we can't do anything about aging, so we need to simply accept that one,  ;D

Finally, we need to remember that our individual journey with HIV is our own.  We won't necessarily run into the same complications as others, but then again, we may.  It's important to pay attention, learn and be aware, but worry, in general, is unhelpful and worry without action is simply a waste.

Mike
Atripla - Started 12/05
Reyataz/Norvir - Added 6/06
Labs - Pre-Meds
Sep05 T=350/25% VL98,559
Nov05 288/18%  47,564
Current Labs
May2013 691/31% <20

Offline aztecan

  • Member
  • Posts: 5,384
  • 29 years positive, 56 years a pain in the butt
Re: Forbes: HIV Drugs may raise heart attack risk!
« Reply #13 on: April 29, 2007, 02:29:59 PM »
I am currently going through some of the "oopsies" that come along with long-term ARV usage.

Don't get me wrong. I am glad to have had them and will deal with whatever comes along. But I think it is naive to think it will be a walk in the park with a "manageable disease."

I think Mike and Ray make very important points. We may not be able to do anything about some of the risks we are exposed to, but we can act to live a healthier life and reduce the risks we do have control over.

I have given up smoking. OK, I just gave up smoking 90 days ago, but still, at least its a start. I exercise three times a week for 90 minutes, including a cardio routine. I try to watch my diet, although I have gained a few pounds since quitting ciggies.

No matter what I do, I will have HIV. No matter what I do, I am experiencing some long-term side effects of the meds. That's life. I am now looking at what I can do to curtail or reduce these side effects.

There may be naught. But its at least worth some research.

The bottom line here is not just to live longer, but to live longer well. If I can pull that off I will be a happy camper. I don't know, maybe I started too late. But we'll see.

But for the many out there who are still young, strong and vibrant - do what you can do to stay that way. Well, strong and vibrant anyway. Aging is another ball of wax.

I have said it, so has Moffie and others. You are the guardian of your own health.

HUGS,

Mark

« Last Edit: April 29, 2007, 02:42:35 PM by aztecan »
"May your life preach more loudly than your lips."
~ William Ellery Channing (Unitarian Minister)

Offline StrongGuy

  • Member
  • Posts: 492
Re: Forbes: HIV Drugs may raise heart attack risk!
« Reply #14 on: April 30, 2007, 12:08:55 AM »
I read that article expecting the study to uncover some new revelation about HIV drugs and heart disease --  but it just reiterated what I've been hearing for many many years about the Protease inhibitors (their lack of lipid friendliness) and increased risk for heart disease.

When I started Kaletra that was one of the first "risks" my doctor mentioned to me. It was also one of the reasons (along with a daily wave of nausea after taking - albeit very manageable otherwise) that made me decide to switch over to Sustiva/Truvada when my doc felt it was OK to do so. Any doctor who put/puts patients on PIs (sans Reyataz which is lipid friendly and less troublesome) and has not/does not (prior to this study or not) have a discussion with their patients about increased risk for heart disease on Protease Inhibitors should have their licenses revoked. This news has been around for long while - study or not.

With that said, at least when I was on Kaletra I knew the pros and cons and the "small but significant hike in risk" for heart disease was worth the alternative. What pisses me off more is when my doctor gave me a script for Celebrex - take it when my knee acts up - and then hear after taking it for awhile that the whole class of COX-2 Inhibitors causes a statistically significant increase in heart disease. Surprises like that pisses me off more.

Mikey :)
"Get your medical advice from Doctors or medical professionals who you trust and know your history."

"Beware of the fortune teller doom and gloomers who seek to bring you down and are only looking for company, purpose and validation - not your best physical/mental interests."

"You know you all are saying that this is incurable. When the real thing you should be saying is it's not curable at the present time' because as we know, the great strides we've made in medicine." - Elizabeth Edwards

Offline aztecan

  • Member
  • Posts: 5,384
  • 29 years positive, 56 years a pain in the butt
Re: Forbes: HIV Drugs may raise heart attack risk!
« Reply #15 on: May 01, 2007, 11:36:53 AM »
Back when I started Crixivan, they didn't know about the lipidemia associated with it.

What I found interesting in the article linked to in this thread was the evidence there is some risk of heart complications simply as a result of HIV infection.

There are a few people here, and I know some others, who have suffered severe heart complications as a result of HIV, not the meds.

All we can do is take the steps we are able to and hope for the best.

HUGS,

Mark
"May your life preach more loudly than your lips."
~ William Ellery Channing (Unitarian Minister)

Offline J.R.E.

  • Member
  • Posts: 7,099
  • Joined Dec-2003 Living positive, since 1985.
Re: Forbes: HIV Drugs may raise heart attack risk!
« Reply #16 on: May 01, 2007, 11:48:55 AM »
Current Meds ; Viramune, Epzicom, 40mg of simvastatin, 12.5mg of Hydrochlorothiazide.
Metoprolol tartrate 25mg



http://forums.poz.com/index.php?topic=40802.0

http://forums.poz.com/index.php?topic=45159.0

http://forums.poz.com/index.php?topic=39722.msg495621;topicseen#msg495621

http://forums.poz.com/index.php?topic=46806.0

http://forums.poz.com/index.php?topic=39414.msg491701#msg491701


 In October of 2003, My t-cell count was 16, Viral load was over 500,000, Percentage at that time was 5%. I started my first  HAART regimen  on October 24th,03.

 As of 6/4/14,  t-cells are at 423, Viral load <40

 Current % is at 13% 

  
 62 years young.

Offline bimazek

  • Member
  • Posts: 781
Re: Forbes: HIV Drugs may raise heart attack risk!
« Reply #17 on: May 01, 2007, 05:46:03 PM »
in one of the mags i think poz or the other one

the doctor who has two pages every issue said about 3 or 4 months ago maybe it was more in the fall of 2006

that he sees very soon that a triple cocktail will NOT contain any nukes, non nukes or protease

for

exactly the reasons people are talkign about above

side effects

he feels that new and first line triple cocktails will be things with lower side effects like

integrase and other ones that i forget the name

so that is where we are trying to get

3 drug cocktail without any of the ones that cause problems

the issue is

enzymes that body needs to do fcns when you inhibit them it causes problems in other parts of body that need that enzyme and also


Offline otherplaces

  • Member
  • Posts: 398
  • Mutant Super Hero
Re: Forbes: HIV Drugs may raise heart attack risk!
« Reply #18 on: May 01, 2007, 07:13:26 PM »

I saw this thread right after I read this:
Epidemic of cardiovascular disease in HIV patients `not on horizon`
http://www.aidsmap.com/en/news/B16BC8B7-496C-4EE6-A6B0-B04135D9000F.asp

I'm sure heart disease is elevated with us, but I'm also sure our high level of smoking isn't really helping the numbers either. **sigh** so good, but soooo bad.

I think bimazek is right.  With integrase and entry inhibitors about ready to hit prime time, and maturation inhibitors right behind 'em they will be looking to see if these are going to be better classes to use for treatment.  PI's and NRTI's could become part of 3rd and 4th line regimens in the not too distant future.

brian

Offline Jake72

  • Member
  • Posts: 145
Re: Forbes: HIV Drugs may raise heart attack risk!
« Reply #19 on: May 01, 2007, 07:28:04 PM »
""This effect was likely explained by a complex process where untreated HIV depletes the 'good' (HDL) cholesterol," he said."

Good God, is there anything that damned virus can't do?   ???

Offline Miss Philicia

  • Member
  • Posts: 23,888
  • celebrity poster, faker & poser
Re: Forbes: HIV Drugs may raise heart attack risk!
« Reply #20 on: May 01, 2007, 07:55:32 PM »
I've had high blood pressure for the past year (well, it's controlled now with Diovan)... thankfully it wasn't dangerously high.  And it's not due to anything like bad lifestyle as I'm a quite trim person, except for some PI related belly fat which can't be helped.  It's minimal though... I can still wear 31" jeans.

I do worry about all these "other" issues.  Someone I semi-know just passed away from lymphatic cancer, complicated by long-term HIV infection.
"I’ve slept with enough men to know that I’m not gay"

 


Terms of Membership for these forums
 

© 2014 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.